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DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 398

Chain	Residue
A	CYS232
A	CYS235
A	CYS249
A	CYS252

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 399

Chain	Residue
A	CYS268
A	CYS274
A	CYS284
A	CYS287

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site_id	ZNA
Number of Residues	5
Details	ZINC COORDINATED BY 4 CYSTEINES

Chain	Residue
A	ZN398
A	CYS232
A	CYS235
A	CYS249
A	CYS252

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site_id	ZNB
Number of Residues	5
Details	ZINC COORDINATED BY 4 CYSTEINES

Chain	Residue
A	CYS287
A	ZN399
A	CYS268
A	CYS274
A	CYS284

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Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CavCg.Dnascq.HYgvrtCegCkgFFkR

Chain	Residue	Details
A	CYS232-ARG258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	ALA264-ARG288

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8227042

Chain	Residue	Details
A	VAL302

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA, RPS6KA1 and RPS6KA3 => ECO:0000269|PubMed:8227042

Chain	Residue	Details
A	GLY312

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