1CHW
CHALCONE SYNTHASE FROM ALFALFA COMPLEXED WITH HEXANOYL-COA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009715 | biological_process | chalcone biosynthetic process |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016210 | molecular_function | naringenin-chalcone synthase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0102128 | molecular_function | chalcone synthase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009715 | biological_process | chalcone biosynthetic process |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016210 | molecular_function | naringenin-chalcone synthase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0102128 | molecular_function | chalcone synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE HXC A 390 |
| Chain | Residue |
| A | VAL210 |
| A | PHE215 |
| A | ILE254 |
| A | PHE265 |
| A | VAL271 |
| A | HIS303 |
| A | GLY305 |
| A | GLY306 |
| A | PRO307 |
| A | ALA308 |
| A | LYS55 |
| A | ILE309 |
| A | ASN336 |
| A | SER338 |
| A | PHE373 |
| A | PRO375 |
| A | HOH498 |
| A | HOH581 |
| A | HOH591 |
| A | ARG58 |
| A | MET59 |
| A | LYS62 |
| A | GLY163 |
| A | SER164 |
| A | LEU206 |
| A | ASP207 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE HXC B 391 |
| Chain | Residue |
| B | LYS55 |
| B | ARG58 |
| B | MET59 |
| B | LYS62 |
| B | GLY163 |
| B | SER164 |
| B | LEU206 |
| B | ASP207 |
| B | VAL210 |
| B | ILE254 |
| B | PHE265 |
| B | LEU267 |
| B | VAL271 |
| B | PRO272 |
| B | HIS303 |
| B | GLY305 |
| B | GLY306 |
| B | PRO307 |
| B | ALA308 |
| B | ILE309 |
| B | ASN336 |
| B | SER338 |
| B | PHE373 |
| B | PRO375 |
| B | HOH558 |
| B | HOH561 |
| site_id | CYS |
| Number of Residues | 1 |
| Details | CATALYTIC SITE, INACTIVATED BY MUTATION C164S |
| Chain | Residue |
| A | SER164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000305 |
| Chain | Residue | Details |
| A | SER164 | |
| B | SER164 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS55 | |
| A | GLY216 | |
| B | LYS55 | |
| B | GLY216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10426957 |
| Chain | Residue | Details |
| A | THR197 | |
| B | THR197 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10426957, ECO:0000269|PubMed:10653632 |
| Chain | Residue | Details |
| A | ALA308 | |
| B | ALA308 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| A | PHE215 | |
| A | SER164 | |
| A | ASN336 | |
| A | HIS303 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| B | PHE215 | |
| B | SER164 | |
| B | ASN336 | |
| B | HIS303 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 355 |
| Chain | Residue | Details |
| A | SER164 | activator, covalently attached, nucleofuge, nucleophile |
| A | PHE215 | electrostatic destabiliser, polar/non-polar interaction |
| A | HIS303 | electrostatic stabiliser, hydrogen bond donor |
| A | ASN336 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 355 |
| Chain | Residue | Details |
| B | SER164 | activator, covalently attached, nucleofuge, nucleophile |
| B | PHE215 | electrostatic destabiliser, polar/non-polar interaction |
| B | HIS303 | electrostatic stabiliser, hydrogen bond donor |
| B | ASN336 | electrostatic stabiliser, hydrogen bond donor |
