1CHU
STRUCTURE OF L-ASPARTATE OXIDASE: IMPLICATIONS FOR THE SUCCINATE DEHYDROGENASE/ FUMARATE REDUCATSE FAMILY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008734 | molecular_function | L-aspartate oxidase activity |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0034628 | biological_process | 'de novo' NAD biosynthetic process from aspartate |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:11294641, ECO:0000305|PubMed:11863440, ECO:0007744|PDB:1KNP |
| Chain | Residue | Details |
| A | ARG290 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11863440, ECO:0007744|PDB:1KNP, ECO:0007744|PDB:1KNR |
| Chain | Residue | Details |
| A | SER16 | |
| A | LYS38 | |
| A | SER45 | |
| A | ASN161 | |
| A | ASP223 | |
| A | GLU375 | |
| A | SER391 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11863440, ECO:0007744|PDB:1KNP |
| Chain | Residue | Details |
| A | HIS244 | |
| A | THR259 | |
| A | SER389 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Important in orienting the L-aspartate substrate => ECO:0000305|PubMed:11294641 |
| Chain | Residue | Details |
| A | GLU121 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d4c |
| Chain | Residue | Details |
| A | ARG386 | |
| A | HIS351 | |
| A | HIS244 | |
| A | ARG284 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d4c |
| Chain | Residue | Details |
| A | ARG386 | |
| A | ARG290 | |
| A | HIS351 | |
| A | HIS244 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 739 |
| Chain | Residue | Details |
| A | GLU121 | electrostatic stabiliser, proton acceptor, steric role |
| A | HIS244 | electrostatic stabiliser |
| A | ARG290 | electrostatic stabiliser, proton acceptor, proton donor |
| A | HIS351 | electrostatic stabiliser |
| A | ARG386 | electrostatic stabiliser |
