1CGF
CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN A 301 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 302 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 303 |
Chain | Residue |
A | ASP175 |
A | GLY176 |
A | GLY178 |
A | ASN180 |
A | ASP198 |
A | GLU201 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 304 |
Chain | Residue |
A | ASP124 |
A | GLU199 |
A | GLU201 |
A | HOH343 |
A | HOH354 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 305 |
Chain | Residue |
A | ASP158 |
A | GLY190 |
A | GLY192 |
A | ASP194 |
A | HOH310 |
A | HOH319 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN B 301 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 302 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 303 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ASN180 |
B | ASP198 |
B | GLU201 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 304 |
Chain | Residue |
B | ASP124 |
B | GLU199 |
B | GLU201 |
B | HOH340 |
B | HOH341 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 305 |
Chain | Residue |
B | ASP158 |
B | GLY190 |
B | GLY192 |
B | ASP194 |
B | HOH310 |
B | HOH377 |
site_id | CTA |
Number of Residues | 10 |
Details |
Chain | Residue |
A | ZN301 |
A | VAL215 |
A | GLY179 |
A | ASN180 |
A | LEU181 |
A | ALA182 |
A | GLU219 |
A | PRO238 |
A | TYR240 |
A | ARG214 |
site_id | CTB |
Number of Residues | 10 |
Details |
Chain | Residue |
B | ZN301 |
B | GLY179 |
B | ASN180 |
B | LEU181 |
B | ALA182 |
B | GLU219 |
B | PRO238 |
B | TYR240 |
B | ARG214 |
B | VAL215 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
A | VAL215-LEU224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 | |
B | GLU219 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP124 | |
B | ASP124 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP158 | |
A | GLY190 | |
A | ASP194 | |
B | ASP158 | |
B | GLY190 | |
B | ASP194 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | HIS168 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
A | HIS183 | |
A | HIS196 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
B | HIS168 | |
B | HIS183 | |
B | HIS196 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP170 | |
B | ASP170 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP175 | |
B | ASP175 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY176 | |
B | GLY176 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY178 | |
A | ASN180 | |
B | GLY178 | |
B | ASN180 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY192 | |
B | GLY192 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP198 | |
B | ASP198 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU199 | |
B | GLU199 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU201 | |
B | GLU201 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | SITE: Not glycosylated => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN143 | |
B | ASN143 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN120 | |
B | ASN120 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET236 | |
A | GLU219 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | MET236 | |
B | GLU219 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU219 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU219 |