1CFH

STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 48

Chain	Residue
A	GLU7
A	GLU8

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 49

Chain	Residue
A	TYR1
A	GLU8

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 50

Chain	Residue
A	GLU15

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 51

Chain	Residue
A	GLU17
A	LYS22

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 52

Chain	Residue
A	GLU20

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 53

Chain	Residue
A	SER24
A	GLU21

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 54

Chain	Residue
A	GLU26

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site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 55

Chain	Residue
A	GLU27

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site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 56

Chain	Residue
A	GLU30
A	VAL31
A	PHE32

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site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 57

Chain	Residue
A	PHE32
A	GLU33

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site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 58

Chain	Residue
A	GLU36

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site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 59

Chain	Residue
A	GLU40

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Functional Information from PROSITE/UniProt

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEkCsfeearEvfentertte.FW

Chain	Residue	Details
A	GLU17-TRP42

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14722079, ECO:0007744|PDB:1NL0

Chain	Residue	Details
A	TYR1
A	ASN2

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: via 4-carboxyglutamate => ECO:0000305|PubMed:14722079, ECO:0007744|PDB:1NL0

Chain	Residue	Details
A	GLU7
A	GLU8
A	GLU17
A	GLU21
A	GLU27

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: via 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741

Chain	Residue	Details
A	GLU15
A	GLU20
A	GLU26
A	GLU30
A	GLU36
A	GLU40

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:7606779, ECO:0007744|PDB:1EDM

Chain	Residue	Details
A	ASP47

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site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741, ECO:0000255|PROSITE-ProRule:PRU00463

Chain	Residue	Details
A	GLU7
A	GLU33
A	GLU36
A	GLU40
A	GLU8
A	GLU15
A	GLU17
A	GLU20
A	GLU21
A	GLU26
A	GLU27
A	GLU30

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:25456591

Chain	Residue	Details
A	THR39

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