1CFH

STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 48

Chain	Residue
A	GLU7
A	GLU8

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 49

Chain	Residue
A	TYR1
A	GLU8

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 50

Chain	Residue
A	GLU15

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 51

Chain	Residue
A	GLU17
A	LYS22

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 52

Chain	Residue
A	GLU20

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 53

Chain	Residue
A	SER24
A	GLU21

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 54

Chain	Residue
A	GLU26

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 55

Chain	Residue
A	GLU27

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 56

Chain	Residue
A	GLU30
A	VAL31
A	PHE32

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 57

Chain	Residue
A	PHE32
A	GLU33

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 58

Chain	Residue
A	GLU36

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 59

Chain	Residue
A	GLU40

---

Functional Information from PROSITE/UniProt

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEkCsfeearEvfentertte.FW

Chain	Residue	Details
A	GLU17-TRP42

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Domain: {"description":"Gla","evidences":[{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14722079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NL0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"description":"via 4-carboxyglutamate","evidences":[{"source":"PubMed","id":"14722079","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NL0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"description":"via 4-carboxyglutamate","evidences":[{"source":"UniProtKB","id":"P00741","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7606779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EDM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"UniProtKB","id":"P00741","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---