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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1CD1

CD1(MOUSE) ANTIGEN PRESENTING MOLECULE

Functional Information from GO Data
ChainGOidnamespacecontents
A0001865biological_processNK T cell differentiation
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002376biological_processimmune system process
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010008cellular_componentendosome membrane
A0019882biological_processantigen processing and presentation
A0030882molecular_functionlipid antigen binding
A0030883molecular_functionendogenous lipid antigen binding
A0030884molecular_functionexogenous lipid antigen binding
A0032729biological_processpositive regulation of type II interferon production
A0032743biological_processpositive regulation of interleukin-2 production
A0032753biological_processpositive regulation of interleukin-4 production
A0033084biological_processregulation of immature T cell proliferation in thymus
A0042102biological_processpositive regulation of T cell proliferation
A0042608molecular_functionT cell receptor binding
A0043032biological_processpositive regulation of macrophage activation
A0045059biological_processpositive thymic T cell selection
A0045087biological_processinnate immune response
A0048006biological_processantigen processing and presentation, endogenous lipid antigen via MHC class Ib
A0048007biological_processantigen processing and presentation, exogenous lipid antigen via MHC class Ib
A0050776biological_processregulation of immune response
A0050839molecular_functioncell adhesion molecule binding
A0051135biological_processpositive regulation of NK T cell activation
A0051138biological_processpositive regulation of NK T cell differentiation
A0071723molecular_functionlipopeptide binding
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0003254biological_processregulation of membrane depolarization
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0006968biological_processcellular defense response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0019731biological_processantibacterial humoral response
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031902cellular_componentlate endosome membrane
B0032398cellular_componentMHC class Ib protein complex
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045087biological_processinnate immune response
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0071222biological_processcellular response to lipopolysaccharide
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
C0001865biological_processNK T cell differentiation
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010008cellular_componentendosome membrane
C0019882biological_processantigen processing and presentation
C0030882molecular_functionlipid antigen binding
C0030883molecular_functionendogenous lipid antigen binding
C0030884molecular_functionexogenous lipid antigen binding
C0032729biological_processpositive regulation of type II interferon production
C0032743biological_processpositive regulation of interleukin-2 production
C0032753biological_processpositive regulation of interleukin-4 production
C0033084biological_processregulation of immature T cell proliferation in thymus
C0042102biological_processpositive regulation of T cell proliferation
C0042608molecular_functionT cell receptor binding
C0043032biological_processpositive regulation of macrophage activation
C0045059biological_processpositive thymic T cell selection
C0045087biological_processinnate immune response
C0048006biological_processantigen processing and presentation, endogenous lipid antigen via MHC class Ib
C0048007biological_processantigen processing and presentation, exogenous lipid antigen via MHC class Ib
C0050776biological_processregulation of immune response
C0050839molecular_functioncell adhesion molecule binding
C0051135biological_processpositive regulation of NK T cell activation
C0051138biological_processpositive regulation of NK T cell differentiation
C0071723molecular_functionlipopeptide binding
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002237biological_processresponse to molecule of bacterial origin
D0002376biological_processimmune system process
D0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
D0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
D0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0002726biological_processpositive regulation of T cell cytokine production
D0003254biological_processregulation of membrane depolarization
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005765cellular_componentlysosomal membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006826biological_processiron ion transport
D0006879biological_processintracellular iron ion homeostasis
D0006955biological_processimmune response
D0006968biological_processcellular defense response
D0007608biological_processsensory perception of smell
D0007611biological_processlearning or memory
D0009897cellular_componentexternal side of plasma membrane
D0010038biological_processresponse to metal ion
D0010977biological_processnegative regulation of neuron projection development
D0019731biological_processantibacterial humoral response
D0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0023026molecular_functionMHC class II protein complex binding
D0030670cellular_componentphagocytic vesicle membrane
D0031902cellular_componentlate endosome membrane
D0032398cellular_componentMHC class Ib protein complex
D0033077biological_processT cell differentiation in thymus
D0033572biological_processtransferrin transport
D0034756biological_processregulation of iron ion transport
D0034757biological_processnegative regulation of iron ion transport
D0042026biological_processprotein refolding
D0042605molecular_functionpeptide antigen binding
D0042612cellular_componentMHC class I protein complex
D0042613cellular_componentMHC class II protein complex
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042824cellular_componentMHC class I peptide loading complex
D0045087biological_processinnate immune response
D0045646biological_processregulation of erythrocyte differentiation
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050768biological_processnegative regulation of neurogenesis
D0050778biological_processpositive regulation of immune response
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0050870biological_processpositive regulation of T cell activation
D0051289biological_processprotein homotetramerization
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0071222biological_processcellular response to lipopolysaccharide
D0071281biological_processcellular response to iron ion
D0071283biological_processcellular response to iron(III) ion
D0071316biological_processcellular response to nicotine
D1990000biological_processamyloid fibril formation
D1990712cellular_componentHFE-transferrin receptor complex
D2000774biological_processpositive regulation of cellular senescence
D2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH
ChainResidueDetails
BTYR78-HIS84
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsDomain: {"description":"Ig-like"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16002697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16314439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16537470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z5L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FIK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16002697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16007091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16314439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16537470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z5L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FIK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16002697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16007091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16537470","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues178
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails

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PDB entries from 2025-12-10

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