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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1CBL

THE 1.9 ANGSTROM STRUCTURE OF DEOXY-BETA4 HEMOGLOBIN: ANALYSIS OF THE PARTITIONING OF QUATERNARY-ASSOCIATED AND LIGAND-INDUCED CHANGES IN TERTIARY STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005344molecular_functionoxygen carrier activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0005833cellular_componenthemoglobin complex
A0006954biological_processinflammatory response
A0008217biological_processregulation of blood pressure
A0015670biological_processcarbon dioxide transport
A0015671biological_processoxygen transport
A0019825molecular_functionoxygen binding
A0020037molecular_functionheme binding
A0030185biological_processnitric oxide transport
A0030492molecular_functionhemoglobin binding
A0031720molecular_functionhaptoglobin binding
A0031721molecular_functionhemoglobin alpha binding
A0031838cellular_componenthaptoglobin-hemoglobin complex
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0046872molecular_functionmetal ion binding
A0048821biological_processerythrocyte development
A0070062cellular_componentextracellular exosome
A0070293biological_processrenal absorption
A0070527biological_processplatelet aggregation
A0071682cellular_componentendocytic vesicle lumen
A0072562cellular_componentblood microparticle
A0097746biological_processblood vessel diameter maintenance
A0098869biological_processcellular oxidant detoxification
A1904724cellular_componenttertiary granule lumen
A1904813cellular_componentficolin-1-rich granule lumen
B0004601molecular_functionperoxidase activity
B0005344molecular_functionoxygen carrier activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0005833cellular_componenthemoglobin complex
B0006954biological_processinflammatory response
B0008217biological_processregulation of blood pressure
B0015670biological_processcarbon dioxide transport
B0015671biological_processoxygen transport
B0019825molecular_functionoxygen binding
B0020037molecular_functionheme binding
B0030185biological_processnitric oxide transport
B0030492molecular_functionhemoglobin binding
B0031720molecular_functionhaptoglobin binding
B0031721molecular_functionhemoglobin alpha binding
B0031838cellular_componenthaptoglobin-hemoglobin complex
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0046872molecular_functionmetal ion binding
B0048821biological_processerythrocyte development
B0070062cellular_componentextracellular exosome
B0070293biological_processrenal absorption
B0070527biological_processplatelet aggregation
B0071682cellular_componentendocytic vesicle lumen
B0072562cellular_componentblood microparticle
B0097746biological_processblood vessel diameter maintenance
B0098869biological_processcellular oxidant detoxification
B1904724cellular_componenttertiary granule lumen
B1904813cellular_componentficolin-1-rich granule lumen
C0004601molecular_functionperoxidase activity
C0005344molecular_functionoxygen carrier activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0005833cellular_componenthemoglobin complex
C0006954biological_processinflammatory response
C0008217biological_processregulation of blood pressure
C0015670biological_processcarbon dioxide transport
C0015671biological_processoxygen transport
C0019825molecular_functionoxygen binding
C0020037molecular_functionheme binding
C0030185biological_processnitric oxide transport
C0030492molecular_functionhemoglobin binding
C0031720molecular_functionhaptoglobin binding
C0031721molecular_functionhemoglobin alpha binding
C0031838cellular_componenthaptoglobin-hemoglobin complex
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0046872molecular_functionmetal ion binding
C0048821biological_processerythrocyte development
C0070062cellular_componentextracellular exosome
C0070293biological_processrenal absorption
C0070527biological_processplatelet aggregation
C0071682cellular_componentendocytic vesicle lumen
C0072562cellular_componentblood microparticle
C0097746biological_processblood vessel diameter maintenance
C0098869biological_processcellular oxidant detoxification
C1904724cellular_componenttertiary granule lumen
C1904813cellular_componentficolin-1-rich granule lumen
D0004601molecular_functionperoxidase activity
D0005344molecular_functionoxygen carrier activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0005833cellular_componenthemoglobin complex
D0006954biological_processinflammatory response
D0008217biological_processregulation of blood pressure
D0015670biological_processcarbon dioxide transport
D0015671biological_processoxygen transport
D0019825molecular_functionoxygen binding
D0020037molecular_functionheme binding
D0030185biological_processnitric oxide transport
D0030492molecular_functionhemoglobin binding
D0031720molecular_functionhaptoglobin binding
D0031721molecular_functionhemoglobin alpha binding
D0031838cellular_componenthaptoglobin-hemoglobin complex
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0046872molecular_functionmetal ion binding
D0048821biological_processerythrocyte development
D0070062cellular_componentextracellular exosome
D0070293biological_processrenal absorption
D0070527biological_processplatelet aggregation
D0071682cellular_componentendocytic vesicle lumen
D0072562cellular_componentblood microparticle
D0097746biological_processblood vessel diameter maintenance
D0098869biological_processcellular oxidant detoxification
D1904724cellular_componenttertiary granule lumen
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 150
ChainResidue
AASN139
AHIS143
AHIS146
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 151
ChainResidue
BLYS82
BASN139
BHIS143
BHIS146
site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 152
ChainResidue
DHIS143
DHIS146
CASN139
DASN139
site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 153
ChainResidue
CHIS143
CHIS146
DASN139
site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE HEM A 147
ChainResidue
APHE41
APHE42
APHE45
AHIS63
ALYS66
AVAL67
AALA70
ALEU88
AHIS92
ALEU96
AASN102
ALEU141
site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE HEM B 147
ChainResidue
BPHE41
BPHE42
BHIS63
BLYS66
BVAL67
BALA70
BPHE71
BHIS92
BLEU96
BASN102
BPHE103
BLEU106
BLEU141
BHOH243
site_idAC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE HEM C 147
ChainResidue
CPHE41
CPHE42
CHIS63
CVAL67
CALA70
CPHE71
CHIS92
CLEU96
CASN102
CLEU106
CLEU141
site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE HEM D 147
ChainResidue
DPHE41
DPHE42
DHIS63
DALA70
DPHE71
DLEU88
DHIS92
DLEU96
DASN102
DLEU106
DLEU141
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsPeptide: {"description":"LVV-hemorphin-7","featureId":"PRO_0000296641"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues24
DetailsPeptide: {"description":"Spinorphin","featureId":"PRO_0000424226"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues576
DetailsDomain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"description":"distal binding residue"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"description":"proximal binding residue"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsSite: {"description":"(Microbial infection) Cleavage; by N.americanus apr-2","evidences":[{"source":"PubMed","id":"12552433","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsSite: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"N-pyruvate 2-iminyl-valine; in Hb A1b"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"8637569","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) valine; in Hb A1c","evidences":[{"source":"PubMed","id":"635569","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues16
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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