Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1CA1

ALPHA-TOXIN FROM CLOSTRIDIUM PERFRINGENS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004629	molecular_function	phospholipase C activity
A	0005576	cellular_component	extracellular region
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0031640	biological_process	killing of cells of another organism
A	0034480	molecular_function	phosphatidylcholine phospholipase C activity
A	0035821	biological_process	modulation of process of another organism
A	0046872	molecular_function	metal ion binding
A	0050429	molecular_function	calcium-dependent phospholipase C activity
A	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 371

Chain	Residue
A	TRP1
A	HIS11
A	ASP130
A	CD373
A	HOH573

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 372

Chain	Residue
A	HIS136
A	HIS148
A	GLU152
A	HOH483
A	HOH573

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 373

Chain	Residue
A	ASP56
A	HIS68
A	HIS126
A	ASP130
A	ZN371
A	HOH572

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 374

Chain	Residue
A	GLY168
A	CYS169
A	HIS207
A	HOH476
A	HOH477
A	HOH492

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 375

Chain	Residue
A	CYS169
A	GLU173
A	ASP216
A	HOH480
A	HOH482

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 376

Chain	Residue
A	GLU173
A	HIS212
A	ASP216
A	HOH494
A	HOH496

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 377

Chain	Residue
A	ASP174
A	ASP178
A	HOH403
A	HOH409
A	HOH455
A	HOH527

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 378

Chain	Residue
A	HIS241
A	GLU245
A	HOH475

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 379

Chain	Residue
A	ASP63
A	ASP293
A	HOH555

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 380

Chain	Residue
A	HIS46
A	GLU359
A	HOH525
A	HOH545

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 381

Chain	Residue
A	GLU157
A	GLU157
A	HOH407
A	HOH407
A	HOH516
A	HOH516

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CD A 382

Chain	Residue
A	ASP273
A	ASP273
A	ASN297
A	ASN297
A	HOH422
A	HOH422
A	HOH427
A	HOH427

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 383

Chain	Residue
A	ALA337
A	HOH495
A	HOH561
A	ASP269
A	GLY271
A	ASP336

site_id	C10
Number of Residues	2
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	HIS46
A	GLU359

site_id	C11
Number of Residues	1
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	GLU157

site_id	C12
Number of Residues	2
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE. POSSIBLE CA BINDING SITE.

Chain	Residue
A	ASP273
A	ASN297

site_id	CA1
Number of Residues	4
Details	POSSIBLE CA BINDING SITE. CURRENTLY LOW OCCUPANCY CD ION (RESIDUE 383)

Chain	Residue
A	ASP336
A	ALA337
A	ASP269
A	GLY271

site_id	CD2
Number of Residues	3
Details	2ND ZINC BINDING SITE, CONTAINING CD FROM CRYSTALLISATION BUFFER.

Chain	Residue
A	HIS136
A	HIS148
A	GLU152

site_id	CD3
Number of Residues	4
Details	3ND ZINC BINDING SITE, CONTAINING CD FROM CRYSTALLISATION BUFFER.

Chain	Residue
A	ASP56
A	ASP130
A	HIS68
A	HIS126

site_id	CD4
Number of Residues	3
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	GLY168
A	CYS169
A	HIS207

site_id	CD5
Number of Residues	3
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	CYS169
A	GLU173
A	ASP216

site_id	CD6
Number of Residues	3
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	GLU173
A	HIS212
A	ASP216

site_id	CD7
Number of Residues	2
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	ASP174
A	ASP178

site_id	CD8
Number of Residues	2
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	HIS241
A	GLU245

site_id	CD9
Number of Residues	2
Details	CD FROM CRYSTALLISATION BUFFER AT PROTEIN SURFACE.

Chain	Residue
A	ASP293
A	ASP63

site_id	ZN1
Number of Residues	3
Details	ZINC BINDING SITE AT ACTIVE SITE.

Chain	Residue
A	TRP1
A	HIS11
A	ASP130

Functional Information from PROSITE/UniProt

site_id	PS00384
Number of Residues	14
Details	PROKAR_ZN_DEPEND_PLPC_1 Prokaryotic zinc-dependent phospholipase C signature. HYfGDIDtPyHPaN

Chain	Residue	Details
A	HIS126-ASN139

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	249
Details	Domain: {"description":"Zn-dependent PLC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00678","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	114
Details	Domain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Linker"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ah7

Chain	Residue	Details
A	ASP56

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)