Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAP A 350 |
| Chain | Residue |
| A | GLY18 |
| A | TYR209 |
| A | SER210 |
| A | PRO211 |
| A | LEU212 |
| A | GLY213 |
| A | SER214 |
| A | ASN216 |
| A | ALA245 |
| A | ILE260 |
| A | PRO261 |
| A | THR19 |
| A | LYS262 |
| A | SER263 |
| A | VAL264 |
| A | THR265 |
| A | ARG268 |
| A | GLU271 |
| A | ASN272 |
| A | HOH407 |
| A | HOH444 |
| A | HOH463 |
| A | TRP20 |
| A | HOH528 |
| A | HOH630 |
| A | HOH645 |
| A | ASP43 |
| A | TYR48 |
| A | HIS110 |
| A | SER159 |
| A | ASN160 |
| A | GLN183 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdeglVKALGVSNF |
| Chain | Residue | Details |
| A | MET144-PHE161 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpaRIhENfQV |
| Chain | Residue | Details |
| A | ILE260-VAL275 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyayynEheVG |
| Chain | Residue | Details |
| A | GLY38-GLY55 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10651037","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR48 | |
| A | ASP43 | |
| A | HIS110 | |
| A | LYS77 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR48 | |
| A | LYS77 | |
1C9W
