1C9B
CRYSTAL STRUCTURE OF A HUMAN TBP CORE DOMAIN-HUMAN TFIIB CORE DOMAIN COMPLEX BOUND TO AN EXTENDED, MODIFIED ADENOVIRAL MAJOR LATE PROMOTER (ADMLP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006352 | biological_process | DNA-templated transcription initiation |
| A | 0017025 | molecular_function | TBP-class protein binding |
| A | 0070897 | biological_process | transcription preinitiation complex assembly |
| B | 0003677 | molecular_function | DNA binding |
| B | 0006352 | biological_process | DNA-templated transcription initiation |
| E | 0006352 | biological_process | DNA-templated transcription initiation |
| E | 0017025 | molecular_function | TBP-class protein binding |
| E | 0070897 | biological_process | transcription preinitiation complex assembly |
| F | 0003677 | molecular_function | DNA binding |
| F | 0006352 | biological_process | DNA-templated transcription initiation |
| I | 0006352 | biological_process | DNA-templated transcription initiation |
| I | 0017025 | molecular_function | TBP-class protein binding |
| I | 0070897 | biological_process | transcription preinitiation complex assembly |
| J | 0003677 | molecular_function | DNA binding |
| J | 0006352 | biological_process | DNA-templated transcription initiation |
| M | 0006352 | biological_process | DNA-templated transcription initiation |
| M | 0017025 | molecular_function | TBP-class protein binding |
| M | 0070897 | biological_process | transcription preinitiation complex assembly |
| N | 0003677 | molecular_function | DNA binding |
| N | 0006352 | biological_process | DNA-templated transcription initiation |
| Q | 0006352 | biological_process | DNA-templated transcription initiation |
| Q | 0017025 | molecular_function | TBP-class protein binding |
| Q | 0070897 | biological_process | transcription preinitiation complex assembly |
| R | 0003677 | molecular_function | DNA binding |
| R | 0006352 | biological_process | DNA-templated transcription initiation |
Functional Information from PROSITE/UniProt
| site_id | PS00351 |
| Number of Residues | 50 |
| Details | TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV |
| Chain | Residue | Details |
| B | TYR192-VAL241 | |
| B | TYR283-LEU332 |
| site_id | PS00782 |
| Number of Residues | 16 |
| Details | TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC |
| Chain | Residue | Details |
| A | GLY153-CYS168 | |
| A | GLY247-SER262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IYD |
| Chain | Residue | Details |
| B | ASN167 | |
| F | ARG294 | |
| J | ASN167 | |
| J | ARG203 | |
| J | LYS218 | |
| J | ASN257 | |
| J | ARG294 | |
| N | ASN167 | |
| N | ARG203 | |
| N | LYS218 | |
| N | ASN257 | |
| B | ARG203 | |
| N | ARG294 | |
| R | ASN167 | |
| R | ARG203 | |
| R | LYS218 | |
| R | ASN257 | |
| R | ARG294 | |
| I | LYS272 | |
| I | ALA281 | |
| I | THR284 | |
| I | ARG286 | |
| B | LYS218 | |
| I | ARG290 | |
| M | LYS152 | |
| M | ARG154 | |
| M | LYS189 | |
| M | LYS196 | |
| M | ARG248 | |
| M | LYS272 | |
| M | ALA281 | |
| M | THR284 | |
| M | ARG286 | |
| B | ASN257 | |
| M | ARG290 | |
| Q | LYS152 | |
| Q | ARG154 | |
| Q | LYS189 | |
| Q | LYS196 | |
| Q | ARG248 | |
| Q | LYS272 | |
| Q | ALA281 | |
| Q | THR284 | |
| Q | ARG286 | |
| B | ARG294 | |
| Q | ARG290 | |
| F | ASN167 | |
| F | ARG203 | |
| F | LYS218 | |
| F | ASN257 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:12931194 |
| Chain | Residue | Details |
| A | LYS238 | |
| E | LYS238 | |
| I | LYS238 | |
| M | LYS238 | |
| Q | LYS238 |
