1C41
CRYSTAL STRUCTURES OF A PENTAMERIC FUNGAL AND AN ICOSAHEDRAL PLANT LUMAZINE SYNTHASE REVEALS THE STRUCTURAL BASIS FOR DIFFERENCES IN ASSEMBLY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0009231 | biological_process | riboflavin biosynthetic process |
| A | 0009349 | cellular_component | riboflavin synthase complex |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0009231 | biological_process | riboflavin biosynthetic process |
| B | 0009349 | cellular_component | riboflavin synthase complex |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| C | 0005758 | cellular_component | mitochondrial intermembrane space |
| C | 0005829 | cellular_component | cytosol |
| C | 0009231 | biological_process | riboflavin biosynthetic process |
| C | 0009349 | cellular_component | riboflavin synthase complex |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| D | 0005758 | cellular_component | mitochondrial intermembrane space |
| D | 0005829 | cellular_component | cytosol |
| D | 0009231 | biological_process | riboflavin biosynthetic process |
| D | 0009349 | cellular_component | riboflavin synthase complex |
| D | 0016740 | molecular_function | transferase activity |
| E | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| E | 0005758 | cellular_component | mitochondrial intermembrane space |
| E | 0005829 | cellular_component | cytosol |
| E | 0009231 | biological_process | riboflavin biosynthetic process |
| E | 0009349 | cellular_component | riboflavin synthase complex |
| E | 0016740 | molecular_function | transferase activity |
| F | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| F | 0005758 | cellular_component | mitochondrial intermembrane space |
| F | 0005829 | cellular_component | cytosol |
| F | 0009231 | biological_process | riboflavin biosynthetic process |
| F | 0009349 | cellular_component | riboflavin synthase complex |
| F | 0016740 | molecular_function | transferase activity |
| G | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| G | 0005758 | cellular_component | mitochondrial intermembrane space |
| G | 0005829 | cellular_component | cytosol |
| G | 0009231 | biological_process | riboflavin biosynthetic process |
| G | 0009349 | cellular_component | riboflavin synthase complex |
| G | 0016740 | molecular_function | transferase activity |
| H | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| H | 0005758 | cellular_component | mitochondrial intermembrane space |
| H | 0005829 | cellular_component | cytosol |
| H | 0009231 | biological_process | riboflavin biosynthetic process |
| H | 0009349 | cellular_component | riboflavin synthase complex |
| H | 0016740 | molecular_function | transferase activity |
| I | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| I | 0005758 | cellular_component | mitochondrial intermembrane space |
| I | 0005829 | cellular_component | cytosol |
| I | 0009231 | biological_process | riboflavin biosynthetic process |
| I | 0009349 | cellular_component | riboflavin synthase complex |
| I | 0016740 | molecular_function | transferase activity |
| J | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| J | 0005758 | cellular_component | mitochondrial intermembrane space |
| J | 0005829 | cellular_component | cytosol |
| J | 0009231 | biological_process | riboflavin biosynthetic process |
| J | 0009349 | cellular_component | riboflavin synthase complex |
| J | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLY123 |
| A | GLU124 |
| A | THR125 |
| A | HIS127 |
| E | ARG166 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | HIS127 |
| A | ARG166 |
| B | GLY123 |
| B | GLU124 |
| B | THR125 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| B | ARG166 |
| C | GLY123 |
| C | GLU124 |
| C | THR125 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 304 |
| Chain | Residue |
| C | ARG166 |
| D | GLY123 |
| D | GLU124 |
| D | THR125 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 305 |
| Chain | Residue |
| D | ARG166 |
| E | GLY123 |
| E | GLU124 |
| E | THR125 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 306 |
| Chain | Residue |
| F | GLY123 |
| F | GLU124 |
| F | THR125 |
| F | HIS127 |
| J | ARG166 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 307 |
| Chain | Residue |
| F | ARG166 |
| G | GLY123 |
| G | GLU124 |
| G | THR125 |
| G | HIS127 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 308 |
| Chain | Residue |
| G | ARG166 |
| H | GLY123 |
| H | GLU124 |
| H | THR125 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 309 |
| Chain | Residue |
| H | ARG166 |
| I | GLY123 |
| I | GLU124 |
| I | THR125 |
| I | HIS127 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 J 310 |
| Chain | Residue |
| I | ARG166 |
| J | GLY123 |
| J | GLU124 |
| J | THR125 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| A | ARG190 |
| B | GLN54 |
| B | SER55 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 402 |
| Chain | Residue |
| C | ARG190 |
| D | GLN54 |
| D | SER55 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 403 |
| Chain | Residue |
| D | ARG190 |
| E | GLN54 |
| E | SER55 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | VAL53 |
| A | GLN54 |
| A | SER55 |
| E | ARG190 |
| H | GLN10 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 F 405 |
| Chain | Residue |
| F | ARG190 |
| G | SER55 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 406 |
| Chain | Residue |
| G | ARG190 |
| H | GLN54 |
| H | SER55 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 I 407 |
| Chain | Residue |
| I | ARG190 |
| J | GLN54 |
| J | SER55 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 J 408 |
| Chain | Residue |
| F | SER55 |
| J | GLN9 |
| J | ARG190 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 I 409 |
| Chain | Residue |
| I | HOH510 |
| site_id | CC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ A 201 |
| Chain | Residue |
| A | TRP25 |
| A | GLY58 |
| A | SER59 |
| A | TRP60 |
| A | GLU61 |
| A | VAL119 |
| A | LEU120 |
| A | ILE121 |
| A | HIS127 |
| A | ILE131 |
| E | ILE151 |
| E | PHE152 |
| site_id | CC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ B 202 |
| Chain | Residue |
| A | ILE151 |
| A | PHE152 |
| B | TRP25 |
| B | GLY58 |
| B | SER59 |
| B | TRP60 |
| B | GLU61 |
| B | VAL119 |
| B | LEU120 |
| B | ILE121 |
| B | HIS127 |
| B | ILE131 |
| site_id | CC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ C 203 |
| Chain | Residue |
| C | SER59 |
| C | TRP60 |
| C | GLU61 |
| C | VAL119 |
| C | LEU120 |
| C | ILE121 |
| C | HIS127 |
| C | ILE131 |
| B | ILE151 |
| B | PHE152 |
| C | TRP25 |
| C | GLY58 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LMZ D 204 |
| Chain | Residue |
| C | ILE151 |
| C | PHE152 |
| D | TRP25 |
| D | ASN26 |
| D | GLY58 |
| D | SER59 |
| D | TRP60 |
| D | GLU61 |
| D | VAL119 |
| D | LEU120 |
| D | ILE121 |
| D | HIS127 |
| D | ILE131 |
| site_id | CC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ E 205 |
| Chain | Residue |
| D | ILE151 |
| D | PHE152 |
| E | TRP25 |
| E | GLY58 |
| E | SER59 |
| E | TRP60 |
| E | GLU61 |
| E | VAL119 |
| E | LEU120 |
| E | ILE121 |
| E | HIS127 |
| E | ILE131 |
| site_id | CC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ F 206 |
| Chain | Residue |
| F | TRP25 |
| F | GLY58 |
| F | SER59 |
| F | TRP60 |
| F | GLU61 |
| F | VAL119 |
| F | LEU120 |
| F | ILE121 |
| F | HIS127 |
| F | ILE131 |
| J | ILE151 |
| J | PHE152 |
| site_id | CC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ G 207 |
| Chain | Residue |
| F | ILE151 |
| F | PHE152 |
| G | TRP25 |
| G | GLY58 |
| G | SER59 |
| G | TRP60 |
| G | GLU61 |
| G | VAL119 |
| G | LEU120 |
| G | ILE121 |
| G | HIS127 |
| G | ILE131 |
| site_id | CC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ H 208 |
| Chain | Residue |
| G | ILE151 |
| G | PHE152 |
| H | TRP25 |
| H | GLY58 |
| H | SER59 |
| H | TRP60 |
| H | GLU61 |
| H | VAL119 |
| H | LEU120 |
| H | ILE121 |
| H | HIS127 |
| H | ILE131 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ I 209 |
| Chain | Residue |
| H | ILE151 |
| H | PHE152 |
| I | TRP25 |
| I | GLY58 |
| I | SER59 |
| I | TRP60 |
| I | GLU61 |
| I | VAL119 |
| I | LEU120 |
| I | ILE121 |
| I | HIS127 |
| I | ILE131 |
| site_id | DC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ J 210 |
| Chain | Residue |
| I | ILE151 |
| I | PHE152 |
| J | TRP25 |
| J | GLY58 |
| J | SER59 |
| J | TRP60 |
| J | GLU61 |
| J | VAL119 |
| J | LEU120 |
| J | ILE121 |
| J | HIS127 |
| J | ILE131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | ACT_SITE: Proton donor => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS127 | |
| B | HIS127 | |
| C | HIS127 | |
| D | HIS127 | |
| E | HIS127 | |
| F | HIS127 | |
| G | HIS127 | |
| H | HIS127 | |
| I | HIS127 | |
| J | HIS127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | BINDING: |
| Chain | Residue | Details |
| C | VAL119 | |
| C | PHE152 | |
| D | TRP25 | |
| D | SER59 | |
| D | VAL119 | |
| D | PHE152 | |
| E | TRP25 | |
| E | SER59 | |
| E | VAL119 | |
| E | PHE152 | |
| F | TRP25 | |
| F | SER59 | |
| F | VAL119 | |
| F | PHE152 | |
| G | TRP25 | |
| G | SER59 | |
| G | VAL119 | |
| G | PHE152 | |
| H | TRP25 | |
| H | SER59 | |
| H | VAL119 | |
| H | PHE152 | |
| I | TRP25 | |
| I | SER59 | |
| I | VAL119 | |
| I | PHE152 | |
| J | TRP25 | |
| J | SER59 | |
| J | VAL119 | |
| J | PHE152 | |
| A | TRP25 | |
| A | SER59 | |
| A | VAL119 | |
| A | PHE152 | |
| B | TRP25 | |
| B | SER59 | |
| B | VAL119 | |
| B | PHE152 | |
| C | TRP25 | |
| C | SER59 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| F | GLU124 | |
| F | ARG166 | |
| G | GLU124 | |
| G | ARG166 | |
| H | GLU124 | |
| H | ARG166 | |
| I | GLU124 | |
| I | ARG166 | |
| J | GLU124 | |
| J | ARG166 | |
| A | GLU124 | |
| A | ARG166 | |
| B | GLU124 | |
| B | ARG166 | |
| C | GLU124 | |
| C | ARG166 | |
| D | GLU124 | |
| D | ARG166 | |
| E | GLU124 | |
| E | ARG166 |
