Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1C41

CRYSTAL STRUCTURES OF A PENTAMERIC FUNGAL AND AN ICOSAHEDRAL PLANT LUMAZINE SYNTHASE REVEALS THE STRUCTURAL BASIS FOR DIFFERENCES IN ASSEMBLY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
A	0005758	cellular_component	mitochondrial intermembrane space
A	0009231	biological_process	riboflavin biosynthetic process
A	0009349	cellular_component	riboflavin synthase complex
A	0016740	molecular_function	transferase activity
B	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
B	0005758	cellular_component	mitochondrial intermembrane space
B	0009231	biological_process	riboflavin biosynthetic process
B	0009349	cellular_component	riboflavin synthase complex
B	0016740	molecular_function	transferase activity
C	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
C	0005758	cellular_component	mitochondrial intermembrane space
C	0009231	biological_process	riboflavin biosynthetic process
C	0009349	cellular_component	riboflavin synthase complex
C	0016740	molecular_function	transferase activity
D	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
D	0005758	cellular_component	mitochondrial intermembrane space
D	0009231	biological_process	riboflavin biosynthetic process
D	0009349	cellular_component	riboflavin synthase complex
D	0016740	molecular_function	transferase activity
E	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
E	0005758	cellular_component	mitochondrial intermembrane space
E	0009231	biological_process	riboflavin biosynthetic process
E	0009349	cellular_component	riboflavin synthase complex
E	0016740	molecular_function	transferase activity
F	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
F	0005758	cellular_component	mitochondrial intermembrane space
F	0009231	biological_process	riboflavin biosynthetic process
F	0009349	cellular_component	riboflavin synthase complex
F	0016740	molecular_function	transferase activity
G	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
G	0005758	cellular_component	mitochondrial intermembrane space
G	0009231	biological_process	riboflavin biosynthetic process
G	0009349	cellular_component	riboflavin synthase complex
G	0016740	molecular_function	transferase activity
H	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
H	0005758	cellular_component	mitochondrial intermembrane space
H	0009231	biological_process	riboflavin biosynthetic process
H	0009349	cellular_component	riboflavin synthase complex
H	0016740	molecular_function	transferase activity
I	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
I	0005758	cellular_component	mitochondrial intermembrane space
I	0009231	biological_process	riboflavin biosynthetic process
I	0009349	cellular_component	riboflavin synthase complex
I	0016740	molecular_function	transferase activity
J	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
J	0005758	cellular_component	mitochondrial intermembrane space
J	0009231	biological_process	riboflavin biosynthetic process
J	0009349	cellular_component	riboflavin synthase complex
J	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	GLY123
A	GLU124
A	THR125
A	HIS127
E	ARG166

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	HIS127
A	ARG166
B	GLY123
B	GLU124
B	THR125

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
B	ARG166
C	GLY123
C	GLU124
C	THR125

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 304

Chain	Residue
C	ARG166
D	GLY123
D	GLU124
D	THR125

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 305

Chain	Residue
D	ARG166
E	GLY123
E	GLU124
E	THR125

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 306

Chain	Residue
F	GLY123
F	GLU124
F	THR125
F	HIS127
J	ARG166

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 307

Chain	Residue
F	ARG166
G	GLY123
G	GLU124
G	THR125
G	HIS127

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 308

Chain	Residue
G	ARG166
H	GLY123
H	GLU124
H	THR125

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 309

Chain	Residue
H	ARG166
I	GLY123
I	GLU124
I	THR125
I	HIS127

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 J 310

Chain	Residue
I	ARG166
J	GLY123
J	GLU124
J	THR125

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
A	ARG190
B	GLN54
B	SER55

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 402

Chain	Residue
C	ARG190
D	GLN54
D	SER55

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 403

Chain	Residue
D	ARG190
E	GLN54
E	SER55

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	VAL53
A	GLN54
A	SER55
E	ARG190
H	GLN10

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 405

Chain	Residue
F	ARG190
G	SER55

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 406

Chain	Residue
G	ARG190
H	GLN54
H	SER55

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 I 407

Chain	Residue
I	ARG190
J	GLN54
J	SER55

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 J 408

Chain	Residue
F	SER55
J	GLN9
J	ARG190

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 I 409

Chain	Residue
I	HOH510

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ A 201

Chain	Residue
A	TRP25
A	GLY58
A	SER59
A	TRP60
A	GLU61
A	VAL119
A	LEU120
A	ILE121
A	HIS127
A	ILE131
E	ILE151
E	PHE152

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ B 202

Chain	Residue
A	ILE151
A	PHE152
B	TRP25
B	GLY58
B	SER59
B	TRP60
B	GLU61
B	VAL119
B	LEU120
B	ILE121
B	HIS127
B	ILE131

site_id	CC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ C 203

Chain	Residue
C	SER59
C	TRP60
C	GLU61
C	VAL119
C	LEU120
C	ILE121
C	HIS127
C	ILE131
B	ILE151
B	PHE152
C	TRP25
C	GLY58

site_id	CC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LMZ D 204

Chain	Residue
C	ILE151
C	PHE152
D	TRP25
D	ASN26
D	GLY58
D	SER59
D	TRP60
D	GLU61
D	VAL119
D	LEU120
D	ILE121
D	HIS127
D	ILE131

site_id	CC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ E 205

Chain	Residue
D	ILE151
D	PHE152
E	TRP25
E	GLY58
E	SER59
E	TRP60
E	GLU61
E	VAL119
E	LEU120
E	ILE121
E	HIS127
E	ILE131

site_id	CC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ F 206

Chain	Residue
F	TRP25
F	GLY58
F	SER59
F	TRP60
F	GLU61
F	VAL119
F	LEU120
F	ILE121
F	HIS127
F	ILE131
J	ILE151
J	PHE152

site_id	CC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ G 207

Chain	Residue
F	ILE151
F	PHE152
G	TRP25
G	GLY58
G	SER59
G	TRP60
G	GLU61
G	VAL119
G	LEU120
G	ILE121
G	HIS127
G	ILE131

site_id	CC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ H 208

Chain	Residue
G	ILE151
G	PHE152
H	TRP25
H	GLY58
H	SER59
H	TRP60
H	GLU61
H	VAL119
H	LEU120
H	ILE121
H	HIS127
H	ILE131

site_id	DC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ I 209

Chain	Residue
H	ILE151
H	PHE152
I	TRP25
I	GLY58
I	SER59
I	TRP60
I	GLU61
I	VAL119
I	LEU120
I	ILE121
I	HIS127
I	ILE131

site_id	DC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ J 210

Chain	Residue
I	ILE151
I	PHE152
J	TRP25
J	GLY58
J	SER59
J	TRP60
J	GLU61
J	VAL119
J	LEU120
J	ILE121
J	HIS127
J	ILE131

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
A	HIS127

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
J	HIS127

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
B	HIS127

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
C	HIS127

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
D	HIS127

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
E	HIS127

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
F	HIS127

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
G	HIS127

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
H	HIS127

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
I	HIS127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)