1C3Q

CRYSTAL STRUCTURE OF NATIVE THIAZOLE KINASE IN THE MONOCLINIC FORM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004417	molecular_function	hydroxyethylthiazole kinase activity
A	0005524	molecular_function	ATP binding
A	0009228	biological_process	thiamine biosynthetic process
A	0009229	biological_process	thiamine diphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0018130	biological_process	obsolete heterocycle biosynthetic process
A	0019438	biological_process	obsolete aromatic compound biosynthetic process
A	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1901362	biological_process	obsolete organic cyclic compound biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004417	molecular_function	hydroxyethylthiazole kinase activity
B	0005524	molecular_function	ATP binding
B	0009228	biological_process	thiamine biosynthetic process
B	0009229	biological_process	thiamine diphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0018130	biological_process	obsolete heterocycle biosynthetic process
B	0019438	biological_process	obsolete aromatic compound biosynthetic process
B	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
B	0046872	molecular_function	metal ion binding
B	1901362	biological_process	obsolete organic cyclic compound biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004417	molecular_function	hydroxyethylthiazole kinase activity
C	0005524	molecular_function	ATP binding
C	0009228	biological_process	thiamine biosynthetic process
C	0009229	biological_process	thiamine diphosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0018130	biological_process	obsolete heterocycle biosynthetic process
C	0019438	biological_process	obsolete aromatic compound biosynthetic process
C	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
C	0046872	molecular_function	metal ion binding
C	1901362	biological_process	obsolete organic cyclic compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 304

Chain	Residue
A	ASN26
B	ASN26
C	ASN26

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TZE A 301

Chain	Residue
C	THR194
C	GLY195
C	CYS198
A	PRO43
A	VAL44
A	MET45
A	HOH371
C	ASN25
C	GLY67

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TZE A 302

Chain	Residue
A	ASN25
A	GLY67
A	GLY195
A	CYS198
A	HOH352
A	HOH365
B	PRO43
B	VAL44
B	MET45

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TZE B 303

Chain	Residue
B	ASN25
B	GLY67
B	THR194
B	GLY195
B	HOH341
C	MET45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00228, ECO:0000269|PubMed:10891066

Chain	Residue	Details
A	MET45
A	GLY195
B	MET45
B	GLY195
C	MET45
C	GLY195

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	ARG121
A	THR168
B	ARG121
B	THR168
C	ARG121
C	THR168

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