Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1C3O

CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 4001

Chain	Residue
A	GLU299
A	ASN301
A	ADP4000
A	MN4002
A	PO44006
A	HOH4092

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 4002

Chain	Residue
A	MN4001
A	PO44006
A	K4020
A	HOH4089
A	GLN285
A	GLU299
A	ADP4000

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 4003

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 4004

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH4092
A	HOH4093

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 4008

Chain	Residue
A	GLN829
A	GLU841
A	ADP4007
A	HOH4557

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 4009

Chain	Residue
A	GLU841
A	ASN843
A	ADP4007

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 4010

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 4015

Chain	Residue
A	GLN93
A	THR173
A	MET174
A	HOH4028
A	HOH4031

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 4016

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 4017

Chain	Residue
A	ASN371
A	PHE900
A	PRO901
A	GLY902

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 4018

Chain	Residue
B	ASP114
B	HOH4081

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 4019

Chain	Residue
B	HIS16
B	ASP112
B	HOH4082
B	HOH4083

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 4020

Chain	Residue
A	GLU217
A	THR244
A	ASN283
A	GLN285
A	MN4002
A	PO44006
A	HOH4098

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 4021

Chain	Residue
A	ASP84
A	GLY112
A	THR114
A	HOH4111
A	HOH4113

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 4022

Chain	Residue
A	THR143
A	ALA144
A	HOH4203

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 4024

Chain	Residue
C	GLU299
C	ASN301
C	ADP4023
C	K4027
C	PO44028
C	HOH4113

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 4025

Chain	Residue
C	GLN285
C	GLU299
C	ADP4023
C	PO44028
C	K4042
C	HOH4110

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 4026

Chain	Residue
C	GLU215
C	ASN236
C	ASP238
C	ALA239
C	ILE242
C	SER247

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K C 4027

Chain	Residue
C	ALA126
C	GLU127
C	GLU299
C	MET300
C	ASN301
C	MN4024
C	HOH4114
C	HOH4709

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 4066

Chain	Residue
E	ALA144
E	HOH4263
E	THR143

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 4030

Chain	Residue
C	GLN829
C	GLU841
C	ADP4029
C	HOH4570
C	HOH4571

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 4069

Chain	Residue
G	GLU299
G	ASN301
G	HOH2947
G	ADP4068
G	MN4070
G	PO44073

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 4031

Chain	Residue
C	GLU841
C	ASN843
C	ADP4029
C	HOH4123

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 4070

Chain	Residue
G	GLN285
G	GLU299
G	HOH2944
G	ADP4068
G	MN4069
G	PO44073

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 4032

Chain	Residue
C	GLU761
C	HIS781
C	GLU783
C	GLN784
C	VAL787
C	SER792

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4071

Chain	Residue
G	GLU215
G	ASN236
G	ASP238
G	ALA239
G	ILE242
G	SER247

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 4037

Chain	Residue
C	THR173
C	MET174
C	HOH4050

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 4072

Chain	Residue
G	ALA126
G	GLU127
G	GLU299
G	MET300
G	ASN301
G	HOH2947
G	HOH2948

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 4038

Chain	Residue
C	ASN289
C	ASN292
C	ARG294

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN G 4075

Chain	Residue
G	GLN829
G	GLU841
G	ADP4074

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 4039

Chain	Residue
C	ASN371
C	PHE900
C	PRO901
C	GLY902

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 4076

Chain	Residue
G	GLU841
G	ASN843
G	ADP4074

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 4040

Chain	Residue
C	GLU549
D	ASP114
D	HOH1501

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4077

Chain	Residue
G	GLU761
G	HIS781
G	GLU783
G	GLN784
G	VAL787
G	SER792

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 4041

Chain	Residue
C	ARG490
C	HOH4558
D	HIS16
D	ASP112
D	HOH1505

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 4082

Chain	Residue
G	GLN93
G	THR173
G	MET174
G	HOH2879

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 4042

Chain	Residue
C	GLU217
C	THR244
C	ASN283
C	GLN285
C	MN4025
C	PO44028
C	HOH4119

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 4083

Chain	Residue
G	ASN289
G	ASN292
G	ARG294

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 4043

Chain	Residue
C	ASP84
C	GLY112
C	THR114
C	HOH4134

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 4084

Chain	Residue
G	ASN371
G	PRO901
G	GLY902

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 4044

Chain	Residue
C	THR143
C	ALA144
C	HOH4221
C	HOH4226

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 4085

Chain	Residue
H	PHE15
H	ASP114

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 4046

Chain	Residue
E	GLU299
E	ASN301
E	ADP4045
E	MN4047
E	PO44050
E	HOH4144

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K H 4086

Chain	Residue
H	HIS16
H	ASP112
H	HOH3432
H	HOH3435

site_id	EC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 4047

Chain	Residue
E	GLN285
E	GLU299
E	ADP4045
E	MN4046
E	PO44050
E	K4064
E	HOH4141

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4087

Chain	Residue
G	GLU217
G	THR244
G	ASN283
G	GLN285
G	HOH2953
G	PO44073

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 4048

Chain	Residue
E	GLU215
E	ASN236
E	ASP238
E	ALA239
E	ILE242
E	SER247

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G 4088

Chain	Residue
G	ASP84
G	GLY112
G	THR114
G	HOH2968
G	HOH2970

site_id	FC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 4049

Chain	Residue
E	ALA126
E	GLU127
E	GLU299
E	MET300
E	ASN301
E	HOH4145

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 4089

Chain	Residue
G	THR143
G	ALA144
G	HOH3052
G	HOH3058

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 4052

Chain	Residue
E	GLN829
E	GLU841
E	ADP4051
E	HOH4614
E	HOH4615

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 4053

Chain	Residue
E	GLU841
E	ASN843
E	ADP4051
E	HOH4154

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 4054

Chain	Residue
E	GLU761
E	HIS781
E	GLU783
E	GLN784
E	VAL787
E	SER792

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 4059

Chain	Residue
E	GLN93
E	THR173
E	MET174
E	HOH4080
E	HOH4083

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 4060

Chain	Residue
E	ASN289
E	ASN292
E	ARG294

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 4061

Chain	Residue
E	ASN371
E	PHE900
E	PRO901
E	GLY902

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F 4062

Chain	Residue
E	GLU549
E	HOH4605
F	PHE15
F	ASP114
F	HOH2477

site_id	GC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K F 4063

Chain	Residue
E	HOH4605
F	HIS16
F	ASP112
F	HOH2481
F	HOH2482

site_id	GC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 4064

Chain	Residue
E	GLU217
E	THR244
E	ASN283
E	GLN285
E	MN4047
E	PO44050
E	HOH4150

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 4065

Chain	Residue
E	ASP84
E	GLY112
E	THR114
E	HOH4166
E	HOH4169

site_id	GC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 E 4050

Chain	Residue
E	MET174
E	GLY175
E	HIS243
E	GLN285
E	GLU299
E	ASN301
E	ARG303
E	ARG306
E	ADP4045
E	MN4046
E	MN4047
E	K4064
E	HOH4150

site_id	GC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 E 4067

Chain	Residue
E	GLU560

site_id	GC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 G 4073

Chain	Residue
G	MET174
G	GLY175
G	HIS243
G	GLN285
G	GLU299
G	ASN301
G	ARG303
G	ARG306
G	HOH2944
G	HOH2953
G	ADP4068
G	MN4069
G	MN4070
G	K4087

site_id	HC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 A 4006

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	ADP4000
A	MN4001
A	MN4002
A	K4020
A	HOH4089
A	HOH4098

site_id	HC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 C 4028

Chain	Residue
C	MET174
C	GLY175
C	HIS243
C	GLN285
C	GLU299
C	ASN301
C	ARG303
C	ARG306
C	ADP4023
C	MN4024
C	MN4025
C	K4042
C	HOH4110
C	HOH4119
C	HOH4120

site_id	HC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN C 4033

Chain	Residue
C	GLU783
C	ASP791
C	GLU892
C	LEU907
C	TYR1040
C	ASP1041
C	THR1042
C	HOH4075
C	HOH4077
C	HOH4105

site_id	HC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLN D 4034

Chain	Residue
D	SER47
D	ASN240
D	GLY241
D	GLY243
D	SER269
D	LEU270
D	GLN273
D	ASN311
D	HIS312
D	GLY313
D	PHE314
D	HIS353
D	HOH995

site_id	HC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GLN C 4035

Chain	Residue
C	ARG528
C	ALA537
C	THR538
C	GLU552
C	ASN554
C	HOH4450
C	HOH4451
C	HOH4456
C	HOH4566
D	ARG120
D	ARG123

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET C 4036

Chain	Residue
C	GLN22
C	THR94
C	ASN97
C	ASN936

site_id	HC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP E 4045

Chain	Residue
E	ARG129
E	ILE167
E	ARG169
E	THR173
E	MET174
E	GLY175
E	GLY176
E	GLU208
E	LEU210
E	ILE211
E	GLU215
E	MET240
E	GLY241
E	ILE242
E	HIS243
E	THR244
E	GLN285
E	ILE298
E	GLU299
E	THR376
E	MN4046
E	MN4047
E	PO44050
E	HOH4137
E	HOH4141
E	HOH4144
E	HOH4613

site_id	HC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP E 4051

Chain	Residue
E	PRO690
E	ARG715
E	MET725
E	HIS754
E	PHE755
E	LEU756
E	GLU761
E	ALA785
E	GLY786
E	VAL787
E	HIS788
E	SER789
E	GLN829
E	GLU841
E	MN4052
E	K4053
E	HOH4153
E	HOH4154
E	HOH4156
E	HOH4614

site_id	HC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN E 4055

Chain	Residue
E	GLU783
E	ASP791
E	GLU892
E	LEU907
E	TYR1040
E	ASP1041
E	THR1042
E	HOH4105
E	HOH4136
E	HOH4616

site_id	IC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLN F 4056

Chain	Residue
F	SER47
F	ASN240
F	GLY241
F	PRO242
F	GLY243
F	SER269
F	LEU270
F	GLN273
F	ASN311
F	HIS312
F	GLY313
F	PHE314
F	HOH1956

site_id	IC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GLN E 4057

Chain	Residue
E	ARG528
E	ALA537
E	THR538
E	GLU552
E	ASN554
E	HOH4492
E	HOH4493
E	HOH4720
E	HOH4721
F	ARG120
F	ARG123

site_id	IC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET E 4058

Chain	Residue
E	GLN22
E	THR94
E	ASN936

site_id	IC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ADP G 4068

Chain	Residue
G	ARG129
G	ILE167
G	ARG169
G	THR173
G	MET174
G	GLY175
G	GLY176
G	GLU208
G	LEU210
G	ILE211
G	GLU215
G	MET240
G	GLY241
G	ILE242
G	HIS243
G	THR244
G	GLN285
G	GLU299
G	HOH2940
G	HOH2944
G	HOH3549
G	MN4069
G	MN4070
G	PO44073

site_id	IC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP G 4074

Chain	Residue
G	ARG715
G	MET725
G	HIS754
G	PHE755
G	LEU756
G	GLU761
G	ALA785
G	GLY786
G	VAL787
G	HIS788
G	SER789
G	GLN829
G	GLU841
G	MN4075
G	K4076

site_id	IC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN G 4078

Chain	Residue
G	GLU783
G	ASP791
G	GLU892
G	VAL893
G	LEU907
G	TYR1040
G	ASP1041
G	THR1042
G	HOH2901
G	HOH2932

site_id	IC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 4000

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	MET174
A	GLY175
A	GLY176
A	GLU208
A	LEU210
A	ILE211
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	ILE298
A	GLU299
A	THR376
A	MN4001
A	MN4002
A	PO44006
A	HOH4085
A	HOH4089
A	HOH4092
A	HOH4556

site_id	IC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GLN H 4079

Chain	Residue
H	SER47
H	ASN240
H	GLY241
H	PRO242
H	GLY243
H	SER269
H	LEU270
H	GLN273
H	ASN311
H	HIS312
H	GLY313
H	PHE314
H	HIS353
H	HOH2934
H	HOH2938

site_id	IC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GLN G 4080

Chain	Residue
G	ARG528
G	ALA537
G	THR538
G	GLU552
G	ASN554
G	HOH3308
H	ARG120
H	ARG123

site_id	JC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP A 4007

Chain	Residue
A	PRO690
A	ARG715
A	MET725
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	MN4008
A	K4009
A	HOH4103
A	HOH4557

site_id	JC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET G 4081

Chain	Residue
G	VAL19
G	THR94
G	ASN97

site_id	JC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN A 4011

Chain	Residue
A	GLU783
A	ASP791
A	GLU892
A	LEU895
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH4053
A	HOH4084

site_id	JC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GLN B 4012

Chain	Residue
B	SER47
B	ASN240
B	GLY241
B	PRO242
B	GLY243
B	SER269
B	LEU270
B	GLN273
B	ASN311
B	HIS312
B	GLY313
B	PHE314
B	HIS353
B	HOH4021
B	HOH4025

site_id	JC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLN A 4013

Chain	Residue
A	ARG528
A	ALA537
A	THR538
A	GLU552
A	ASN554
A	HOH4436
A	HOH4437
A	HOH4561
B	ARG120
B	ARG123

site_id	JC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET A 4014

Chain	Residue
A	GLN22
A	THR94
A	ASN936

site_id	JC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP C 4023

Chain	Residue
C	ARG129
C	ILE167
C	ARG169
C	THR173
C	MET174
C	GLY175
C	GLY176
C	GLU208
C	LEU210
C	ILE211
C	GLU215
C	MET240
C	GLY241
C	ILE242
C	HIS243
C	THR244
C	GLN285
C	ILE298
C	GLU299
C	THR376
C	MN4024
C	MN4025
C	PO44028
C	HOH4106
C	HOH4110
C	HOH4113
C	HOH4567

site_id	JC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP C 4029

Chain	Residue
C	PRO690
C	ARG715
C	MET725
C	HIS754
C	PHE755
C	LEU756
C	GLU761
C	ALA785
C	GLY786
C	VAL787
C	HIS788
C	SER789
C	GLN829
C	GLU841
C	MN4030
C	K4031
C	HOH4122
C	HOH4123
C	HOH4570
C	HOH4571

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	748
Details	Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	SER269

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	SER269

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	SER269

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	SER269

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	SER269	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	HIS353	proton shuttle (general acid/base)
B	GLU355	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	SER269	covalent catalysis, proton shuttle (general acid/base)
C	ARG303	electrostatic stabiliser
C	ARG715	electrostatic stabiliser
C	GLU761	steric role
C	GLN829	metal ligand
C	GLU841	metal ligand
C	ASN843	metal ligand
C	ARG848	electrostatic stabiliser
D	HIS353	proton shuttle (general acid/base)
D	GLU355	steric role
C	GLU215	steric role
C	HIS243	proton shuttle (general acid/base)
C	ASN283	electrostatic stabiliser
C	GLN285	metal ligand
C	GLU299	metal ligand
C	ASN301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	SER269	covalent catalysis, proton shuttle (general acid/base)
E	ARG303	electrostatic stabiliser
E	ARG715	electrostatic stabiliser
E	GLU761	steric role
E	GLN829	metal ligand
E	GLU841	metal ligand
E	ASN843	metal ligand
E	ARG848	electrostatic stabiliser
F	HIS353	proton shuttle (general acid/base)
F	GLU355	steric role
E	GLU215	steric role
E	HIS243	proton shuttle (general acid/base)
E	ASN283	electrostatic stabiliser
E	GLN285	metal ligand
E	GLU299	metal ligand
E	ASN301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	SER269	covalent catalysis, proton shuttle (general acid/base)
G	ARG303	electrostatic stabiliser
G	ARG715	electrostatic stabiliser
G	GLU761	steric role
G	GLN829	metal ligand
G	GLU841	metal ligand
G	ASN843	metal ligand
G	ARG848	electrostatic stabiliser
H	HIS353	proton shuttle (general acid/base)
H	GLU355	steric role
G	GLU215	steric role
G	HIS243	proton shuttle (general acid/base)
G	ASN283	electrostatic stabiliser
G	GLN285	metal ligand
G	GLU299	metal ligand
G	ASN301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)