1C3O
CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006526 | biological_process | arginine biosynthetic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0016597 | molecular_function | amino acid binding |
A | 0016874 | molecular_function | ligase activity |
A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
B | 0004359 | molecular_function | glutaminase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006526 | biological_process | arginine biosynthetic process |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0016874 | molecular_function | ligase activity |
B | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0046982 | molecular_function | protein heterodimerization activity |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006526 | biological_process | arginine biosynthetic process |
C | 0006541 | biological_process | glutamine metabolic process |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0016597 | molecular_function | amino acid binding |
C | 0016874 | molecular_function | ligase activity |
C | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0046872 | molecular_function | metal ion binding |
D | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
D | 0004359 | molecular_function | glutaminase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0006526 | biological_process | arginine biosynthetic process |
D | 0006541 | biological_process | glutamine metabolic process |
D | 0016874 | molecular_function | ligase activity |
D | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0046982 | molecular_function | protein heterodimerization activity |
E | 0000166 | molecular_function | nucleotide binding |
E | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
E | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
E | 0006526 | biological_process | arginine biosynthetic process |
E | 0006541 | biological_process | glutamine metabolic process |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0016597 | molecular_function | amino acid binding |
E | 0016874 | molecular_function | ligase activity |
E | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
E | 0046872 | molecular_function | metal ion binding |
F | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
F | 0004359 | molecular_function | glutaminase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
F | 0006526 | biological_process | arginine biosynthetic process |
F | 0006541 | biological_process | glutamine metabolic process |
F | 0016874 | molecular_function | ligase activity |
F | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
F | 0046982 | molecular_function | protein heterodimerization activity |
G | 0000166 | molecular_function | nucleotide binding |
G | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
G | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
G | 0005515 | molecular_function | protein binding |
G | 0005524 | molecular_function | ATP binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
G | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
G | 0006526 | biological_process | arginine biosynthetic process |
G | 0006541 | biological_process | glutamine metabolic process |
G | 0008652 | biological_process | amino acid biosynthetic process |
G | 0016597 | molecular_function | amino acid binding |
G | 0016874 | molecular_function | ligase activity |
G | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
G | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
G | 0046872 | molecular_function | metal ion binding |
H | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
H | 0004359 | molecular_function | glutaminase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005524 | molecular_function | ATP binding |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
H | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
H | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
H | 0006526 | biological_process | arginine biosynthetic process |
H | 0006541 | biological_process | glutamine metabolic process |
H | 0016874 | molecular_function | ligase activity |
H | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
H | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
H | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 4001 |
Chain | Residue |
A | GLU299 |
A | ASN301 |
A | ADP4000 |
A | MN4002 |
A | PO44006 |
A | HOH4092 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN A 4002 |
Chain | Residue |
A | MN4001 |
A | PO44006 |
A | K4020 |
A | HOH4089 |
A | GLN285 |
A | GLU299 |
A | ADP4000 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 4003 |
Chain | Residue |
A | GLU215 |
A | ASN236 |
A | ASP238 |
A | ALA239 |
A | ILE242 |
A | SER247 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K A 4004 |
Chain | Residue |
A | ALA126 |
A | GLU127 |
A | GLU299 |
A | MET300 |
A | ASN301 |
A | HOH4092 |
A | HOH4093 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 4008 |
Chain | Residue |
A | GLN829 |
A | GLU841 |
A | ADP4007 |
A | HOH4557 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 4009 |
Chain | Residue |
A | GLU841 |
A | ASN843 |
A | ADP4007 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 4010 |
Chain | Residue |
A | GLU761 |
A | HIS781 |
A | GLU783 |
A | GLN784 |
A | VAL787 |
A | SER792 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 4015 |
Chain | Residue |
A | GLN93 |
A | THR173 |
A | MET174 |
A | HOH4028 |
A | HOH4031 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 4016 |
Chain | Residue |
A | ASN289 |
A | ASN292 |
A | ARG294 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 4017 |
Chain | Residue |
A | ASN371 |
A | PHE900 |
A | PRO901 |
A | GLY902 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 4018 |
Chain | Residue |
B | ASP114 |
B | HOH4081 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K B 4019 |
Chain | Residue |
B | HIS16 |
B | ASP112 |
B | HOH4082 |
B | HOH4083 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K A 4020 |
Chain | Residue |
A | GLU217 |
A | THR244 |
A | ASN283 |
A | GLN285 |
A | MN4002 |
A | PO44006 |
A | HOH4098 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 4021 |
Chain | Residue |
A | ASP84 |
A | GLY112 |
A | THR114 |
A | HOH4111 |
A | HOH4113 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 4022 |
Chain | Residue |
A | THR143 |
A | ALA144 |
A | HOH4203 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 4024 |
Chain | Residue |
C | GLU299 |
C | ASN301 |
C | ADP4023 |
C | K4027 |
C | PO44028 |
C | HOH4113 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 4025 |
Chain | Residue |
C | GLN285 |
C | GLU299 |
C | ADP4023 |
C | PO44028 |
C | K4042 |
C | HOH4110 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 4026 |
Chain | Residue |
C | GLU215 |
C | ASN236 |
C | ASP238 |
C | ALA239 |
C | ILE242 |
C | SER247 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE K C 4027 |
Chain | Residue |
C | ALA126 |
C | GLU127 |
C | GLU299 |
C | MET300 |
C | ASN301 |
C | MN4024 |
C | HOH4114 |
C | HOH4709 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K E 4066 |
Chain | Residue |
E | ALA144 |
E | HOH4263 |
E | THR143 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 4030 |
Chain | Residue |
C | GLN829 |
C | GLU841 |
C | ADP4029 |
C | HOH4570 |
C | HOH4571 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN G 4069 |
Chain | Residue |
G | GLU299 |
G | ASN301 |
G | HOH2947 |
G | ADP4068 |
G | MN4070 |
G | PO44073 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K C 4031 |
Chain | Residue |
C | GLU841 |
C | ASN843 |
C | ADP4029 |
C | HOH4123 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN G 4070 |
Chain | Residue |
G | GLN285 |
G | GLU299 |
G | HOH2944 |
G | ADP4068 |
G | MN4069 |
G | PO44073 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 4032 |
Chain | Residue |
C | GLU761 |
C | HIS781 |
C | GLU783 |
C | GLN784 |
C | VAL787 |
C | SER792 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K G 4071 |
Chain | Residue |
G | GLU215 |
G | ASN236 |
G | ASP238 |
G | ALA239 |
G | ILE242 |
G | SER247 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 4037 |
Chain | Residue |
C | THR173 |
C | MET174 |
C | HOH4050 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K G 4072 |
Chain | Residue |
G | ALA126 |
G | GLU127 |
G | GLU299 |
G | MET300 |
G | ASN301 |
G | HOH2947 |
G | HOH2948 |
site_id | DC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 4038 |
Chain | Residue |
C | ASN289 |
C | ASN292 |
C | ARG294 |
site_id | DC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MN G 4075 |
Chain | Residue |
G | GLN829 |
G | GLU841 |
G | ADP4074 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL C 4039 |
Chain | Residue |
C | ASN371 |
C | PHE900 |
C | PRO901 |
C | GLY902 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K G 4076 |
Chain | Residue |
G | GLU841 |
G | ASN843 |
G | ADP4074 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL D 4040 |
Chain | Residue |
C | GLU549 |
D | ASP114 |
D | HOH1501 |
site_id | DC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K G 4077 |
Chain | Residue |
G | GLU761 |
G | HIS781 |
G | GLU783 |
G | GLN784 |
G | VAL787 |
G | SER792 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 4041 |
Chain | Residue |
C | ARG490 |
C | HOH4558 |
D | HIS16 |
D | ASP112 |
D | HOH1505 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL G 4082 |
Chain | Residue |
G | GLN93 |
G | THR173 |
G | MET174 |
G | HOH2879 |
site_id | EC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K C 4042 |
Chain | Residue |
C | GLU217 |
C | THR244 |
C | ASN283 |
C | GLN285 |
C | MN4025 |
C | PO44028 |
C | HOH4119 |
site_id | EC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 4083 |
Chain | Residue |
G | ASN289 |
G | ASN292 |
G | ARG294 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K C 4043 |
Chain | Residue |
C | ASP84 |
C | GLY112 |
C | THR114 |
C | HOH4134 |
site_id | EC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 4084 |
Chain | Residue |
G | ASN371 |
G | PRO901 |
G | GLY902 |
site_id | EC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K C 4044 |
Chain | Residue |
C | THR143 |
C | ALA144 |
C | HOH4221 |
C | HOH4226 |
site_id | EC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL H 4085 |
Chain | Residue |
H | PHE15 |
H | ASP114 |
site_id | EC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN E 4046 |
Chain | Residue |
E | GLU299 |
E | ASN301 |
E | ADP4045 |
E | MN4047 |
E | PO44050 |
E | HOH4144 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K H 4086 |
Chain | Residue |
H | HIS16 |
H | ASP112 |
H | HOH3432 |
H | HOH3435 |
site_id | EC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN E 4047 |
Chain | Residue |
E | GLN285 |
E | GLU299 |
E | ADP4045 |
E | MN4046 |
E | PO44050 |
E | K4064 |
E | HOH4141 |
site_id | FC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K G 4087 |
Chain | Residue |
G | GLU217 |
G | THR244 |
G | ASN283 |
G | GLN285 |
G | HOH2953 |
G | PO44073 |
site_id | FC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 4048 |
Chain | Residue |
E | GLU215 |
E | ASN236 |
E | ASP238 |
E | ALA239 |
E | ILE242 |
E | SER247 |
site_id | FC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K G 4088 |
Chain | Residue |
G | ASP84 |
G | GLY112 |
G | THR114 |
G | HOH2968 |
G | HOH2970 |
site_id | FC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 4049 |
Chain | Residue |
E | ALA126 |
E | GLU127 |
E | GLU299 |
E | MET300 |
E | ASN301 |
E | HOH4145 |
site_id | FC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K G 4089 |
Chain | Residue |
G | THR143 |
G | ALA144 |
G | HOH3052 |
G | HOH3058 |
site_id | FC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN E 4052 |
Chain | Residue |
E | GLN829 |
E | GLU841 |
E | ADP4051 |
E | HOH4614 |
E | HOH4615 |
site_id | FC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K E 4053 |
Chain | Residue |
E | GLU841 |
E | ASN843 |
E | ADP4051 |
E | HOH4154 |
site_id | FC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 4054 |
Chain | Residue |
E | GLU761 |
E | HIS781 |
E | GLU783 |
E | GLN784 |
E | VAL787 |
E | SER792 |
site_id | FC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL E 4059 |
Chain | Residue |
E | GLN93 |
E | THR173 |
E | MET174 |
E | HOH4080 |
E | HOH4083 |
site_id | GC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL E 4060 |
Chain | Residue |
E | ASN289 |
E | ASN292 |
E | ARG294 |
site_id | GC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL E 4061 |
Chain | Residue |
E | ASN371 |
E | PHE900 |
E | PRO901 |
E | GLY902 |
site_id | GC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL F 4062 |
Chain | Residue |
E | GLU549 |
E | HOH4605 |
F | PHE15 |
F | ASP114 |
F | HOH2477 |
site_id | GC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K F 4063 |
Chain | Residue |
E | HOH4605 |
F | HIS16 |
F | ASP112 |
F | HOH2481 |
F | HOH2482 |
site_id | GC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K E 4064 |
Chain | Residue |
E | GLU217 |
E | THR244 |
E | ASN283 |
E | GLN285 |
E | MN4047 |
E | PO44050 |
E | HOH4150 |
site_id | GC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K E 4065 |
Chain | Residue |
E | ASP84 |
E | GLY112 |
E | THR114 |
E | HOH4166 |
E | HOH4169 |
site_id | GC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PO4 E 4050 |
Chain | Residue |
E | MET174 |
E | GLY175 |
E | HIS243 |
E | GLN285 |
E | GLU299 |
E | ASN301 |
E | ARG303 |
E | ARG306 |
E | ADP4045 |
E | MN4046 |
E | MN4047 |
E | K4064 |
E | HOH4150 |
site_id | GC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PO4 E 4067 |
Chain | Residue |
E | GLU560 |
site_id | GC9 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PO4 G 4073 |
Chain | Residue |
G | MET174 |
G | GLY175 |
G | HIS243 |
G | GLN285 |
G | GLU299 |
G | ASN301 |
G | ARG303 |
G | ARG306 |
G | HOH2944 |
G | HOH2953 |
G | ADP4068 |
G | MN4069 |
G | MN4070 |
G | K4087 |
site_id | HC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PO4 A 4006 |
Chain | Residue |
A | MET174 |
A | GLY175 |
A | HIS243 |
A | GLN285 |
A | GLU299 |
A | ASN301 |
A | ARG303 |
A | ARG306 |
A | ADP4000 |
A | MN4001 |
A | MN4002 |
A | K4020 |
A | HOH4089 |
A | HOH4098 |
site_id | HC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PO4 C 4028 |
Chain | Residue |
C | MET174 |
C | GLY175 |
C | HIS243 |
C | GLN285 |
C | GLU299 |
C | ASN301 |
C | ARG303 |
C | ARG306 |
C | ADP4023 |
C | MN4024 |
C | MN4025 |
C | K4042 |
C | HOH4110 |
C | HOH4119 |
C | HOH4120 |
site_id | HC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN C 4033 |
Chain | Residue |
C | GLU783 |
C | ASP791 |
C | GLU892 |
C | LEU907 |
C | TYR1040 |
C | ASP1041 |
C | THR1042 |
C | HOH4075 |
C | HOH4077 |
C | HOH4105 |
site_id | HC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GLN D 4034 |
Chain | Residue |
D | SER47 |
D | ASN240 |
D | GLY241 |
D | GLY243 |
D | SER269 |
D | LEU270 |
D | GLN273 |
D | ASN311 |
D | HIS312 |
D | GLY313 |
D | PHE314 |
D | HIS353 |
D | HOH995 |
site_id | HC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GLN C 4035 |
Chain | Residue |
C | ARG528 |
C | ALA537 |
C | THR538 |
C | GLU552 |
C | ASN554 |
C | HOH4450 |
C | HOH4451 |
C | HOH4456 |
C | HOH4566 |
D | ARG120 |
D | ARG123 |
site_id | HC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NET C 4036 |
Chain | Residue |
C | GLN22 |
C | THR94 |
C | ASN97 |
C | ASN936 |
site_id | HC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE ADP E 4045 |
Chain | Residue |
E | ARG129 |
E | ILE167 |
E | ARG169 |
E | THR173 |
E | MET174 |
E | GLY175 |
E | GLY176 |
E | GLU208 |
E | LEU210 |
E | ILE211 |
E | GLU215 |
E | MET240 |
E | GLY241 |
E | ILE242 |
E | HIS243 |
E | THR244 |
E | GLN285 |
E | ILE298 |
E | GLU299 |
E | THR376 |
E | MN4046 |
E | MN4047 |
E | PO44050 |
E | HOH4137 |
E | HOH4141 |
E | HOH4144 |
E | HOH4613 |
site_id | HC8 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP E 4051 |
Chain | Residue |
E | PRO690 |
E | ARG715 |
E | MET725 |
E | HIS754 |
E | PHE755 |
E | LEU756 |
E | GLU761 |
E | ALA785 |
E | GLY786 |
E | VAL787 |
E | HIS788 |
E | SER789 |
E | GLN829 |
E | GLU841 |
E | MN4052 |
E | K4053 |
E | HOH4153 |
E | HOH4154 |
E | HOH4156 |
E | HOH4614 |
site_id | HC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN E 4055 |
Chain | Residue |
E | GLU783 |
E | ASP791 |
E | GLU892 |
E | LEU907 |
E | TYR1040 |
E | ASP1041 |
E | THR1042 |
E | HOH4105 |
E | HOH4136 |
E | HOH4616 |
site_id | IC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GLN F 4056 |
Chain | Residue |
F | SER47 |
F | ASN240 |
F | GLY241 |
F | PRO242 |
F | GLY243 |
F | SER269 |
F | LEU270 |
F | GLN273 |
F | ASN311 |
F | HIS312 |
F | GLY313 |
F | PHE314 |
F | HOH1956 |
site_id | IC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GLN E 4057 |
Chain | Residue |
E | ARG528 |
E | ALA537 |
E | THR538 |
E | GLU552 |
E | ASN554 |
E | HOH4492 |
E | HOH4493 |
E | HOH4720 |
E | HOH4721 |
F | ARG120 |
F | ARG123 |
site_id | IC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NET E 4058 |
Chain | Residue |
E | GLN22 |
E | THR94 |
E | ASN936 |
site_id | IC4 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE ADP G 4068 |
Chain | Residue |
G | ARG129 |
G | ILE167 |
G | ARG169 |
G | THR173 |
G | MET174 |
G | GLY175 |
G | GLY176 |
G | GLU208 |
G | LEU210 |
G | ILE211 |
G | GLU215 |
G | MET240 |
G | GLY241 |
G | ILE242 |
G | HIS243 |
G | THR244 |
G | GLN285 |
G | GLU299 |
G | HOH2940 |
G | HOH2944 |
G | HOH3549 |
G | MN4069 |
G | MN4070 |
G | PO44073 |
site_id | IC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE ADP G 4074 |
Chain | Residue |
G | ARG715 |
G | MET725 |
G | HIS754 |
G | PHE755 |
G | LEU756 |
G | GLU761 |
G | ALA785 |
G | GLY786 |
G | VAL787 |
G | HIS788 |
G | SER789 |
G | GLN829 |
G | GLU841 |
G | MN4075 |
G | K4076 |
site_id | IC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN G 4078 |
Chain | Residue |
G | GLU783 |
G | ASP791 |
G | GLU892 |
G | VAL893 |
G | LEU907 |
G | TYR1040 |
G | ASP1041 |
G | THR1042 |
G | HOH2901 |
G | HOH2932 |
site_id | IC7 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE ADP A 4000 |
Chain | Residue |
A | ARG129 |
A | ILE167 |
A | ARG169 |
A | MET174 |
A | GLY175 |
A | GLY176 |
A | GLU208 |
A | LEU210 |
A | ILE211 |
A | GLU215 |
A | MET240 |
A | GLY241 |
A | ILE242 |
A | HIS243 |
A | THR244 |
A | GLN285 |
A | ILE298 |
A | GLU299 |
A | THR376 |
A | MN4001 |
A | MN4002 |
A | PO44006 |
A | HOH4085 |
A | HOH4089 |
A | HOH4092 |
A | HOH4556 |
site_id | IC8 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE GLN H 4079 |
Chain | Residue |
H | SER47 |
H | ASN240 |
H | GLY241 |
H | PRO242 |
H | GLY243 |
H | SER269 |
H | LEU270 |
H | GLN273 |
H | ASN311 |
H | HIS312 |
H | GLY313 |
H | PHE314 |
H | HIS353 |
H | HOH2934 |
H | HOH2938 |
site_id | IC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GLN G 4080 |
Chain | Residue |
G | ARG528 |
G | ALA537 |
G | THR538 |
G | GLU552 |
G | ASN554 |
G | HOH3308 |
H | ARG120 |
H | ARG123 |
site_id | JC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP A 4007 |
Chain | Residue |
A | PRO690 |
A | ARG715 |
A | MET725 |
A | HIS754 |
A | PHE755 |
A | LEU756 |
A | GLU761 |
A | ALA785 |
A | GLY786 |
A | VAL787 |
A | HIS788 |
A | SER789 |
A | GLN829 |
A | GLU841 |
A | MN4008 |
A | K4009 |
A | HOH4103 |
A | HOH4557 |
site_id | JC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NET G 4081 |
Chain | Residue |
G | VAL19 |
G | THR94 |
G | ASN97 |
site_id | JC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN A 4011 |
Chain | Residue |
A | GLU783 |
A | ASP791 |
A | GLU892 |
A | LEU895 |
A | LEU907 |
A | TYR1040 |
A | ASP1041 |
A | THR1042 |
A | HOH4053 |
A | HOH4084 |
site_id | JC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE GLN B 4012 |
Chain | Residue |
B | SER47 |
B | ASN240 |
B | GLY241 |
B | PRO242 |
B | GLY243 |
B | SER269 |
B | LEU270 |
B | GLN273 |
B | ASN311 |
B | HIS312 |
B | GLY313 |
B | PHE314 |
B | HIS353 |
B | HOH4021 |
B | HOH4025 |
site_id | JC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GLN A 4013 |
Chain | Residue |
A | ARG528 |
A | ALA537 |
A | THR538 |
A | GLU552 |
A | ASN554 |
A | HOH4436 |
A | HOH4437 |
A | HOH4561 |
B | ARG120 |
B | ARG123 |
site_id | JC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NET A 4014 |
Chain | Residue |
A | GLN22 |
A | THR94 |
A | ASN936 |
site_id | JC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE ADP C 4023 |
Chain | Residue |
C | ARG129 |
C | ILE167 |
C | ARG169 |
C | THR173 |
C | MET174 |
C | GLY175 |
C | GLY176 |
C | GLU208 |
C | LEU210 |
C | ILE211 |
C | GLU215 |
C | MET240 |
C | GLY241 |
C | ILE242 |
C | HIS243 |
C | THR244 |
C | GLN285 |
C | ILE298 |
C | GLU299 |
C | THR376 |
C | MN4024 |
C | MN4025 |
C | PO44028 |
C | HOH4106 |
C | HOH4110 |
C | HOH4113 |
C | HOH4567 |
site_id | JC8 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP C 4029 |
Chain | Residue |
C | PRO690 |
C | ARG715 |
C | MET725 |
C | HIS754 |
C | PHE755 |
C | LEU756 |
C | GLU761 |
C | ALA785 |
C | GLY786 |
C | VAL787 |
C | HIS788 |
C | SER789 |
C | GLN829 |
C | GLU841 |
C | MN4030 |
C | K4031 |
C | HOH4122 |
C | HOH4123 |
C | HOH4570 |
C | HOH4571 |
Functional Information from PROSITE/UniProt
site_id | PS00866 |
Number of Residues | 15 |
Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG |
Chain | Residue | Details |
A | PHE164-GLY178 | |
A | TYR710-ALA724 |
site_id | PS00867 |
Number of Residues | 8 |
Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV |
Chain | Residue | Details |
A | VAL297-VAL304 | |
A | LEU839-ALA846 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 |
Chain | Residue | Details |
B | SER269 | |
A | HIS243 | |
A | ARG715 | |
A | HIS754 | |
A | LEU756 | |
A | GLU761 | |
A | GLY786 | |
A | VAL787 | |
A | HIS788 | |
A | SER789 | |
C | ARG129 | |
D | SER269 | |
C | ARG169 | |
C | GLY175 | |
C | GLY176 | |
C | GLU208 | |
C | LEU210 | |
C | GLU215 | |
C | GLY241 | |
C | ILE242 | |
C | HIS243 | |
C | ARG715 | |
F | SER269 | |
C | HIS754 | |
C | LEU756 | |
C | GLU761 | |
C | GLY786 | |
C | VAL787 | |
C | HIS788 | |
C | SER789 | |
E | ARG129 | |
E | ARG169 | |
E | GLY175 | |
H | SER269 | |
E | GLY176 | |
E | GLU208 | |
E | LEU210 | |
E | GLU215 | |
E | GLY241 | |
E | ILE242 | |
E | HIS243 | |
E | ARG715 | |
E | HIS754 | |
E | LEU756 | |
A | GLU208 | |
E | GLU761 | |
E | GLY786 | |
E | VAL787 | |
E | HIS788 | |
E | SER789 | |
G | ARG129 | |
G | ARG169 | |
G | GLY175 | |
G | GLY176 | |
G | GLU208 | |
A | LEU210 | |
G | LEU210 | |
G | GLU215 | |
G | GLY241 | |
G | ILE242 | |
G | HIS243 | |
G | ARG715 | |
G | HIS754 | |
G | LEU756 | |
G | GLU761 | |
G | GLY786 | |
A | GLU215 | |
G | VAL787 | |
G | HIS788 | |
G | SER789 | |
A | GLY241 | |
A | ILE242 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01209 |
Chain | Residue | Details |
B | HIS353 | |
B | GLU355 | |
D | HIS353 | |
D | GLU355 | |
F | HIS353 | |
F | GLU355 | |
H | HIS353 | |
H | GLU355 |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01209, ECO:0000269|PubMed:10587438, ECO:0007744|PDB:1C3O |
Chain | Residue | Details |
B | SER47 | |
D | GLY241 | |
D | GLY243 | |
D | LEU270 | |
D | GLN273 | |
D | ASN311 | |
D | GLY313 | |
D | PHE314 | |
F | SER47 | |
F | GLY241 | |
F | GLY243 | |
B | GLY241 | |
F | LEU270 | |
F | GLN273 | |
F | ASN311 | |
F | GLY313 | |
F | PHE314 | |
H | SER47 | |
H | GLY241 | |
H | GLY243 | |
H | LEU270 | |
H | GLN273 | |
B | GLY243 | |
H | ASN311 | |
H | GLY313 | |
H | PHE314 | |
B | LEU270 | |
B | GLN273 | |
B | ASN311 | |
B | GLY313 | |
B | PHE314 | |
D | SER47 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
Chain | Residue | Details |
A | GLN829 | |
C | GLN829 | |
E | GLN829 | |
G | GLN829 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
Chain | Residue | Details |
A | GLU841 | |
C | GLU841 | |
E | GLU841 | |
G | GLU841 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 |
Chain | Residue | Details |
A | ASN843 | |
C | ASN843 | |
E | ASN843 | |
G | ASN843 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
B | HIS353 | |
B | SER269 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
D | HIS353 | |
D | SER269 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
F | HIS353 | |
F | SER269 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
H | HIS353 | |
H | SER269 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
B | SER269 | covalent catalysis, proton shuttle (general acid/base) |
A | ARG303 | electrostatic stabiliser |
A | ARG715 | electrostatic stabiliser |
A | GLY721 | electrostatic stabiliser |
A | GLY722 | electrostatic stabiliser |
A | GLU761 | steric role |
A | GLN829 | metal ligand |
A | GLU841 | metal ligand |
A | ASN843 | metal ligand |
A | ARG848 | electrostatic stabiliser |
B | HIS353 | proton shuttle (general acid/base) |
B | GLU355 | steric role |
A | GLU215 | steric role |
A | HIS243 | proton shuttle (general acid/base) |
A | ASN283 | electrostatic stabiliser |
A | GLN285 | metal ligand |
A | GLU299 | metal ligand |
A | ASN301 | metal ligand |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
D | SER269 | covalent catalysis, proton shuttle (general acid/base) |
C | ARG303 | electrostatic stabiliser |
C | ARG715 | electrostatic stabiliser |
C | GLY721 | electrostatic stabiliser |
C | GLY722 | electrostatic stabiliser |
C | GLU761 | steric role |
C | GLN829 | metal ligand |
C | GLU841 | metal ligand |
C | ASN843 | metal ligand |
C | ARG848 | electrostatic stabiliser |
D | HIS353 | proton shuttle (general acid/base) |
D | GLU355 | steric role |
C | GLU215 | steric role |
C | HIS243 | proton shuttle (general acid/base) |
C | ASN283 | electrostatic stabiliser |
C | GLN285 | metal ligand |
C | GLU299 | metal ligand |
C | ASN301 | metal ligand |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
F | SER269 | covalent catalysis, proton shuttle (general acid/base) |
E | ARG303 | electrostatic stabiliser |
E | ARG715 | electrostatic stabiliser |
E | GLY721 | electrostatic stabiliser |
E | GLY722 | electrostatic stabiliser |
E | GLU761 | steric role |
E | GLN829 | metal ligand |
E | GLU841 | metal ligand |
E | ASN843 | metal ligand |
E | ARG848 | electrostatic stabiliser |
F | HIS353 | proton shuttle (general acid/base) |
F | GLU355 | steric role |
E | GLU215 | steric role |
E | HIS243 | proton shuttle (general acid/base) |
E | ASN283 | electrostatic stabiliser |
E | GLN285 | metal ligand |
E | GLU299 | metal ligand |
E | ASN301 | metal ligand |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
H | SER269 | covalent catalysis, proton shuttle (general acid/base) |
G | ARG303 | electrostatic stabiliser |
G | ARG715 | electrostatic stabiliser |
G | GLY721 | electrostatic stabiliser |
G | GLY722 | electrostatic stabiliser |
G | GLU761 | steric role |
G | GLN829 | metal ligand |
G | GLU841 | metal ligand |
G | ASN843 | metal ligand |
G | ARG848 | electrostatic stabiliser |
H | HIS353 | proton shuttle (general acid/base) |
H | GLU355 | steric role |
G | GLU215 | steric role |
G | HIS243 | proton shuttle (general acid/base) |
G | ASN283 | electrostatic stabiliser |
G | GLN285 | metal ligand |
G | GLU299 | metal ligand |
G | ASN301 | metal ligand |