1C2Y
CRYSTAL STRUCTURES OF A PENTAMERIC FUNGAL AND AN ICOSAHEDRAL PLANT LUMAZINE SYNTHASE REVEALS THE STRUCTURAL BASIS FOR DIFFERENCES IN ASSEMBLY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| A | 0009231 | biological_process | riboflavin biosynthetic process |
| A | 0009349 | cellular_component | riboflavin synthase complex |
| B | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| B | 0009231 | biological_process | riboflavin biosynthetic process |
| B | 0009349 | cellular_component | riboflavin synthase complex |
| C | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| C | 0009231 | biological_process | riboflavin biosynthetic process |
| C | 0009349 | cellular_component | riboflavin synthase complex |
| D | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| D | 0009231 | biological_process | riboflavin biosynthetic process |
| D | 0009349 | cellular_component | riboflavin synthase complex |
| E | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| E | 0009231 | biological_process | riboflavin biosynthetic process |
| E | 0009349 | cellular_component | riboflavin synthase complex |
| F | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| F | 0009231 | biological_process | riboflavin biosynthetic process |
| F | 0009349 | cellular_component | riboflavin synthase complex |
| G | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| G | 0009231 | biological_process | riboflavin biosynthetic process |
| G | 0009349 | cellular_component | riboflavin synthase complex |
| H | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| H | 0009231 | biological_process | riboflavin biosynthetic process |
| H | 0009349 | cellular_component | riboflavin synthase complex |
| I | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| I | 0009231 | biological_process | riboflavin biosynthetic process |
| I | 0009349 | cellular_component | riboflavin synthase complex |
| J | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| J | 0009231 | biological_process | riboflavin biosynthetic process |
| J | 0009349 | cellular_component | riboflavin synthase complex |
| K | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| K | 0009231 | biological_process | riboflavin biosynthetic process |
| K | 0009349 | cellular_component | riboflavin synthase complex |
| L | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| L | 0009231 | biological_process | riboflavin biosynthetic process |
| L | 0009349 | cellular_component | riboflavin synthase complex |
| M | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| M | 0009231 | biological_process | riboflavin biosynthetic process |
| M | 0009349 | cellular_component | riboflavin synthase complex |
| N | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| N | 0009231 | biological_process | riboflavin biosynthetic process |
| N | 0009349 | cellular_component | riboflavin synthase complex |
| O | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| O | 0009231 | biological_process | riboflavin biosynthetic process |
| O | 0009349 | cellular_component | riboflavin synthase complex |
| P | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| P | 0009231 | biological_process | riboflavin biosynthetic process |
| P | 0009349 | cellular_component | riboflavin synthase complex |
| Q | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| Q | 0009231 | biological_process | riboflavin biosynthetic process |
| Q | 0009349 | cellular_component | riboflavin synthase complex |
| R | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| R | 0009231 | biological_process | riboflavin biosynthetic process |
| R | 0009349 | cellular_component | riboflavin synthase complex |
| S | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| S | 0009231 | biological_process | riboflavin biosynthetic process |
| S | 0009349 | cellular_component | riboflavin synthase complex |
| T | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| T | 0009231 | biological_process | riboflavin biosynthetic process |
| T | 0009349 | cellular_component | riboflavin synthase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMZ A 201 |
| Chain | Residue |
| A | PHE23 |
| A | GLY55 |
| A | ALA56 |
| A | TYR57 |
| A | GLU58 |
| A | ALA80 |
| A | VAL81 |
| E | VAL112 |
| E | PHE113 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ B 202 |
| Chain | Residue |
| A | VAL112 |
| A | PHE113 |
| B | PHE23 |
| B | GLY55 |
| B | ALA56 |
| B | TYR57 |
| B | GLU58 |
| B | ALA80 |
| B | VAL81 |
| B | VAL92 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ C 203 |
| Chain | Residue |
| B | VAL112 |
| B | PHE113 |
| C | PHE23 |
| C | ASN24 |
| C | GLY55 |
| C | ALA56 |
| C | TYR57 |
| C | GLU58 |
| C | ALA80 |
| C | VAL81 |
| C | VAL92 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ D 204 |
| Chain | Residue |
| C | VAL112 |
| C | PHE113 |
| D | PHE23 |
| D | GLY55 |
| D | ALA56 |
| D | TYR57 |
| D | GLU58 |
| D | ALA80 |
| D | VAL81 |
| D | VAL92 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ E 205 |
| Chain | Residue |
| D | VAL112 |
| D | PHE113 |
| D | LYS135 |
| E | PHE23 |
| E | GLY55 |
| E | ALA56 |
| E | TYR57 |
| E | GLU58 |
| E | ALA80 |
| E | VAL81 |
| E | HIS88 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMZ F 206 |
| Chain | Residue |
| F | PHE23 |
| F | GLY55 |
| F | ALA56 |
| F | TYR57 |
| F | GLU58 |
| F | ALA80 |
| F | VAL81 |
| J | VAL112 |
| J | PHE113 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ G 207 |
| Chain | Residue |
| F | VAL112 |
| F | PHE113 |
| G | PHE23 |
| G | ASN24 |
| G | GLY55 |
| G | ALA56 |
| G | TYR57 |
| G | GLU58 |
| G | ALA80 |
| G | VAL81 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ H 208 |
| Chain | Residue |
| G | VAL112 |
| G | PHE113 |
| H | PHE23 |
| H | ASN24 |
| H | GLY55 |
| H | ALA56 |
| H | TYR57 |
| H | GLU58 |
| H | ALA80 |
| H | VAL81 |
| H | VAL92 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ I 209 |
| Chain | Residue |
| H | VAL112 |
| H | PHE113 |
| I | PHE23 |
| I | ASN24 |
| I | GLY55 |
| I | ALA56 |
| I | TYR57 |
| I | GLU58 |
| I | ALA80 |
| I | VAL81 |
| I | VAL92 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ J 210 |
| Chain | Residue |
| J | GLU58 |
| J | ALA80 |
| J | VAL81 |
| J | VAL82 |
| J | VAL92 |
| I | VAL112 |
| I | PHE113 |
| J | PHE23 |
| J | ASN24 |
| J | GLY55 |
| J | ALA56 |
| J | TYR57 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ K 211 |
| Chain | Residue |
| K | PHE23 |
| K | GLY55 |
| K | ALA56 |
| K | TYR57 |
| K | GLU58 |
| K | ALA80 |
| K | VAL81 |
| K | VAL92 |
| O | VAL112 |
| O | PHE113 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMZ L 212 |
| Chain | Residue |
| K | VAL112 |
| K | PHE113 |
| L | PHE23 |
| L | GLY55 |
| L | ALA56 |
| L | TYR57 |
| L | GLU58 |
| L | ALA80 |
| L | VAL81 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ M 213 |
| Chain | Residue |
| L | VAL112 |
| L | PHE113 |
| M | PHE23 |
| M | ASN24 |
| M | GLY55 |
| M | ALA56 |
| M | TYR57 |
| M | GLU58 |
| M | ALA80 |
| M | VAL81 |
| M | VAL82 |
| M | VAL92 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ N 214 |
| Chain | Residue |
| M | VAL112 |
| M | PHE113 |
| N | PHE23 |
| N | ASN24 |
| N | GLY55 |
| N | ALA56 |
| N | TYR57 |
| N | GLU58 |
| N | ALA80 |
| N | VAL81 |
| N | VAL82 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ O 215 |
| Chain | Residue |
| N | PHE113 |
| O | PHE23 |
| O | ASN24 |
| O | GLY55 |
| O | ALA56 |
| O | TYR57 |
| O | GLU58 |
| O | ALA80 |
| O | VAL81 |
| O | VAL82 |
| O | VAL92 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ P 216 |
| Chain | Residue |
| P | PHE23 |
| P | ASN24 |
| P | GLY55 |
| P | ALA56 |
| P | TYR57 |
| P | GLU58 |
| P | ALA80 |
| P | VAL81 |
| T | VAL112 |
| T | PHE113 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ Q 217 |
| Chain | Residue |
| P | VAL112 |
| P | PHE113 |
| Q | PHE23 |
| Q | ASN24 |
| Q | GLY55 |
| Q | ALA56 |
| Q | TYR57 |
| Q | GLU58 |
| Q | ALA80 |
| Q | VAL81 |
| Q | VAL82 |
| Q | VAL92 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE LMZ R 218 |
| Chain | Residue |
| Q | PHE113 |
| R | PHE23 |
| R | ASN24 |
| R | GLY55 |
| R | ALA56 |
| R | TYR57 |
| R | GLU58 |
| R | ALA80 |
| R | VAL81 |
| R | VAL82 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMZ S 219 |
| Chain | Residue |
| R | VAL112 |
| R | PHE113 |
| S | PHE23 |
| S | ASN24 |
| S | GLY55 |
| S | ALA56 |
| S | TYR57 |
| S | GLU58 |
| S | ALA80 |
| S | VAL81 |
| S | VAL92 |
| site_id | CC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LMZ T 220 |
| Chain | Residue |
| S | VAL112 |
| S | PHE113 |
| T | PHE23 |
| T | ASN24 |
| T | GLY55 |
| T | ALA56 |
| T | TYR57 |
| T | GLU58 |
| T | ALA80 |
| T | VAL81 |
| T | VAL82 |
| T | VAL92 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| A | HIS88 |
| site_id | CSA10 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| J | HIS88 |
| site_id | CSA11 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| K | HIS88 |
| site_id | CSA12 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| L | HIS88 |
| site_id | CSA13 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| M | HIS88 |
| site_id | CSA14 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| N | HIS88 |
| site_id | CSA15 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| O | HIS88 |
| site_id | CSA16 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| P | HIS88 |
| site_id | CSA17 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| Q | HIS88 |
| site_id | CSA18 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| R | HIS88 |
| site_id | CSA19 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| S | HIS88 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| B | HIS88 |
| site_id | CSA20 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| T | HIS88 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| C | HIS88 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| D | HIS88 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| E | HIS88 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| F | HIS88 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| G | HIS88 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| H | HIS88 |
| site_id | CSA9 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| I | HIS88 |
