Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1C2Y

CRYSTAL STRUCTURES OF A PENTAMERIC FUNGAL AND AN ICOSAHEDRAL PLANT LUMAZINE SYNTHASE REVEALS THE STRUCTURAL BASIS FOR DIFFERENCES IN ASSEMBLY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
A	0009231	biological_process	riboflavin biosynthetic process
A	0009349	cellular_component	riboflavin synthase complex
B	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
B	0009231	biological_process	riboflavin biosynthetic process
B	0009349	cellular_component	riboflavin synthase complex
C	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
C	0009231	biological_process	riboflavin biosynthetic process
C	0009349	cellular_component	riboflavin synthase complex
D	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
D	0009231	biological_process	riboflavin biosynthetic process
D	0009349	cellular_component	riboflavin synthase complex
E	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
E	0009231	biological_process	riboflavin biosynthetic process
E	0009349	cellular_component	riboflavin synthase complex
F	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
F	0009231	biological_process	riboflavin biosynthetic process
F	0009349	cellular_component	riboflavin synthase complex
G	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
G	0009231	biological_process	riboflavin biosynthetic process
G	0009349	cellular_component	riboflavin synthase complex
H	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
H	0009231	biological_process	riboflavin biosynthetic process
H	0009349	cellular_component	riboflavin synthase complex
I	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
I	0009231	biological_process	riboflavin biosynthetic process
I	0009349	cellular_component	riboflavin synthase complex
J	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
J	0009231	biological_process	riboflavin biosynthetic process
J	0009349	cellular_component	riboflavin synthase complex
K	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
K	0009231	biological_process	riboflavin biosynthetic process
K	0009349	cellular_component	riboflavin synthase complex
L	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
L	0009231	biological_process	riboflavin biosynthetic process
L	0009349	cellular_component	riboflavin synthase complex
M	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
M	0009231	biological_process	riboflavin biosynthetic process
M	0009349	cellular_component	riboflavin synthase complex
N	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
N	0009231	biological_process	riboflavin biosynthetic process
N	0009349	cellular_component	riboflavin synthase complex
O	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
O	0009231	biological_process	riboflavin biosynthetic process
O	0009349	cellular_component	riboflavin synthase complex
P	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
P	0009231	biological_process	riboflavin biosynthetic process
P	0009349	cellular_component	riboflavin synthase complex
Q	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
Q	0009231	biological_process	riboflavin biosynthetic process
Q	0009349	cellular_component	riboflavin synthase complex
R	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
R	0009231	biological_process	riboflavin biosynthetic process
R	0009349	cellular_component	riboflavin synthase complex
S	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
S	0009231	biological_process	riboflavin biosynthetic process
S	0009349	cellular_component	riboflavin synthase complex
T	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
T	0009231	biological_process	riboflavin biosynthetic process
T	0009349	cellular_component	riboflavin synthase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMZ A 201

Chain	Residue
A	PHE23
A	GLY55
A	ALA56
A	TYR57
A	GLU58
A	ALA80
A	VAL81
E	VAL112
E	PHE113

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ B 202

Chain	Residue
A	VAL112
A	PHE113
B	PHE23
B	GLY55
B	ALA56
B	TYR57
B	GLU58
B	ALA80
B	VAL81
B	VAL92

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ C 203

Chain	Residue
B	VAL112
B	PHE113
C	PHE23
C	ASN24
C	GLY55
C	ALA56
C	TYR57
C	GLU58
C	ALA80
C	VAL81
C	VAL92

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ D 204

Chain	Residue
C	VAL112
C	PHE113
D	PHE23
D	GLY55
D	ALA56
D	TYR57
D	GLU58
D	ALA80
D	VAL81
D	VAL92

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ E 205

Chain	Residue
D	VAL112
D	PHE113
D	LYS135
E	PHE23
E	GLY55
E	ALA56
E	TYR57
E	GLU58
E	ALA80
E	VAL81
E	HIS88

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMZ F 206

Chain	Residue
F	PHE23
F	GLY55
F	ALA56
F	TYR57
F	GLU58
F	ALA80
F	VAL81
J	VAL112
J	PHE113

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ G 207

Chain	Residue
F	VAL112
F	PHE113
G	PHE23
G	ASN24
G	GLY55
G	ALA56
G	TYR57
G	GLU58
G	ALA80
G	VAL81

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ H 208

Chain	Residue
G	VAL112
G	PHE113
H	PHE23
H	ASN24
H	GLY55
H	ALA56
H	TYR57
H	GLU58
H	ALA80
H	VAL81
H	VAL92

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ I 209

Chain	Residue
H	VAL112
H	PHE113
I	PHE23
I	ASN24
I	GLY55
I	ALA56
I	TYR57
I	GLU58
I	ALA80
I	VAL81
I	VAL92

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ J 210

Chain	Residue
J	GLU58
J	ALA80
J	VAL81
J	VAL82
J	VAL92
I	VAL112
I	PHE113
J	PHE23
J	ASN24
J	GLY55
J	ALA56
J	TYR57

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ K 211

Chain	Residue
K	PHE23
K	GLY55
K	ALA56
K	TYR57
K	GLU58
K	ALA80
K	VAL81
K	VAL92
O	VAL112
O	PHE113

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMZ L 212

Chain	Residue
K	VAL112
K	PHE113
L	PHE23
L	GLY55
L	ALA56
L	TYR57
L	GLU58
L	ALA80
L	VAL81

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ M 213

Chain	Residue
L	VAL112
L	PHE113
M	PHE23
M	ASN24
M	GLY55
M	ALA56
M	TYR57
M	GLU58
M	ALA80
M	VAL81
M	VAL82
M	VAL92

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ N 214

Chain	Residue
M	VAL112
M	PHE113
N	PHE23
N	ASN24
N	GLY55
N	ALA56
N	TYR57
N	GLU58
N	ALA80
N	VAL81
N	VAL82

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ O 215

Chain	Residue
N	PHE113
O	PHE23
O	ASN24
O	GLY55
O	ALA56
O	TYR57
O	GLU58
O	ALA80
O	VAL81
O	VAL82
O	VAL92

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ P 216

Chain	Residue
P	PHE23
P	ASN24
P	GLY55
P	ALA56
P	TYR57
P	GLU58
P	ALA80
P	VAL81
T	VAL112
T	PHE113

site_id	BC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ Q 217

Chain	Residue
P	VAL112
P	PHE113
Q	PHE23
Q	ASN24
Q	GLY55
Q	ALA56
Q	TYR57
Q	GLU58
Q	ALA80
Q	VAL81
Q	VAL82
Q	VAL92

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMZ R 218

Chain	Residue
Q	PHE113
R	PHE23
R	ASN24
R	GLY55
R	ALA56
R	TYR57
R	GLU58
R	ALA80
R	VAL81
R	VAL82

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMZ S 219

Chain	Residue
R	VAL112
R	PHE113
S	PHE23
S	ASN24
S	GLY55
S	ALA56
S	TYR57
S	GLU58
S	ALA80
S	VAL81
S	VAL92

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMZ T 220

Chain	Residue
S	VAL112
S	PHE113
T	PHE23
T	ASN24
T	GLY55
T	ALA56
T	TYR57
T	GLU58
T	ALA80
T	VAL81
T	VAL82
T	VAL92

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ACT_SITE: Proton donor => ECO:0000255

Chain	Residue	Details
A	HIS88
J	HIS88
K	HIS88
L	HIS88
M	HIS88
N	HIS88
O	HIS88
P	HIS88
Q	HIS88
R	HIS88
S	HIS88
B	HIS88
T	HIS88
C	HIS88
D	HIS88
E	HIS88
F	HIS88
G	HIS88
H	HIS88
I	HIS88

site_id	SWS_FT_FI2
Number of Residues	120
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	PHE23
B	ASP85
Q	ASP85
Q	PHE113
Q	ARG127
R	PHE23
R	ALA56
R	ALA80
R	ASP85
R	PHE113
R	ARG127
S	PHE23
B	PHE113
S	ALA56
S	ALA80
S	ASP85
S	PHE113
S	ARG127
T	PHE23
T	ALA56
T	ALA80
T	ASP85
T	PHE113
B	ARG127
T	ARG127
C	PHE23
C	ALA56
C	ALA80
C	ASP85
C	PHE113
C	ARG127
D	PHE23
A	ALA56
D	ALA56
D	ALA80
D	ASP85
D	PHE113
D	ARG127
E	PHE23
E	ALA56
E	ALA80
E	ASP85
E	PHE113
A	ALA80
E	ARG127
F	PHE23
F	ALA56
F	ALA80
F	ASP85
F	PHE113
F	ARG127
G	PHE23
G	ALA56
G	ALA80
A	ASP85
G	ASP85
G	PHE113
G	ARG127
H	PHE23
H	ALA56
H	ALA80
H	ASP85
H	PHE113
H	ARG127
I	PHE23
A	PHE113
I	ALA56
I	ALA80
I	ASP85
I	PHE113
I	ARG127
J	PHE23
J	ALA56
J	ALA80
J	ASP85
J	PHE113
A	ARG127
J	ARG127
K	PHE23
K	ALA56
K	ALA80
K	ASP85
K	PHE113
K	ARG127
L	PHE23
L	ALA56
L	ALA80
B	PHE23
L	ASP85
L	PHE113
L	ARG127
M	PHE23
M	ALA56
M	ALA80
M	ASP85
M	PHE113
M	ARG127
N	PHE23
B	ALA56
N	ALA56
N	ALA80
N	ASP85
N	PHE113
N	ARG127
O	PHE23
O	ALA56
O	ALA80
O	ASP85
O	PHE113
B	ALA80
O	ARG127
P	PHE23
P	ALA56
P	ALA80
P	ASP85
P	PHE113
P	ARG127
Q	PHE23
Q	ALA56
Q	ALA80

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
A	HIS88

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
J	HIS88

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
K	HIS88

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
L	HIS88

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
M	HIS88

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
N	HIS88

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
O	HIS88

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
P	HIS88

site_id	CSA17
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
Q	HIS88

site_id	CSA18
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
R	HIS88

site_id	CSA19
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
S	HIS88

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
B	HIS88

site_id	CSA20
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
T	HIS88

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
C	HIS88

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
D	HIS88

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
E	HIS88

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
F	HIS88

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
G	HIS88

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
H	HIS88

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
I	HIS88

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)