1C1V
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Functional Information from GO Data
Chain | GOid | namespace | contents |
H | 0004252 | molecular_function | serine-type endopeptidase activity |
H | 0005509 | molecular_function | calcium ion binding |
H | 0006508 | biological_process | proteolysis |
H | 0007596 | biological_process | blood coagulation |
L | 0004252 | molecular_function | serine-type endopeptidase activity |
L | 0005576 | cellular_component | extracellular region |
L | 0006508 | biological_process | proteolysis |
L | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN H 254 |
Chain | Residue |
H | HIS57 |
H | SER201 |
H | BAB410 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ZN H 255 |
Chain | Residue |
H | BAB410 |
H | HOH546 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA H 409 |
Chain | Residue |
H | HOH452 |
H | HOH454 |
H | ARG227 |
H | LYS230 |
H | HOH428 |
H | HOH431 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE BAB H 410 |
Chain | Residue |
H | LEU41 |
H | LYS60 |
H | ASP195 |
H | ALA196 |
H | GLU198 |
H | SER201 |
H | VAL219 |
H | TRP221 |
H | GLY222 |
H | GLY225 |
H | ZN254 |
H | ZN255 |
H | HOH545 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR CHAIN I OF PROTEIN (ACETYL HIRUDIN) |
Chain | Residue |
H | PHE34 |
H | LYS36 |
H | GLN38 |
H | LEU40 |
H | LEU65 |
H | ARG73 |
H | THR74 |
H | ARG75 |
H | TYR76 |
H | LYS81 |
H | ILE82 |
H | MET84 |
I | HOH499 |
I | HOH597 |
I | HOH790 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | Active site: {"description":"Charge relay system"} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | HIS57 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | SER201 | |
H | GLY202 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | GLY199 | |
H | SER201 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | GLY199 | |
H | ASP102 | |
H | SER201 | |
H | HIS57 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER201 | |
H | HIS57 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER201 | |
H | HIS57 | |
H | GLY202 |