1C1D
L-PHENYLALANINE DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NADH AND L-PHENYLALANINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| A | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| B | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 850 |
| Chain | Residue |
| A | ASP118 |
| A | THR121 |
| A | HOH1493 |
| A | HOH1602 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 851 |
| Chain | Residue |
| B | HOH1194 |
| B | HOH1421 |
| B | LEU170 |
| B | SER172 |
| B | ASP174 |
| B | LEU176 |
| B | PO4880 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 852 |
| Chain | Residue |
| B | ASP118 |
| B | THR121 |
| B | HOH1320 |
| B | HOH1452 |
| B | HOH1667 |
| B | HOH1746 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 853 |
| Chain | Residue |
| A | VAL136 |
| A | PHE137 |
| A | GLY138 |
| A | ARG139 |
| A | GLY145 |
| A | GLU299 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 854 |
| Chain | Residue |
| B | ASP30 |
| B | HOH1094 |
| B | HOH1140 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 855 |
| Chain | Residue |
| B | GLN200 |
| B | LEU201 |
| B | HIS219 |
| B | HOH1067 |
| B | HOH1754 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 B 880 |
| Chain | Residue |
| B | SER1 |
| B | SER4 |
| B | THR54 |
| B | LYS58 |
| B | LEU170 |
| B | LEU176 |
| B | K851 |
| B | HOH1106 |
| B | HOH1168 |
| B | HOH1421 |
| B | HOH1456 |
| B | HOH1510 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PHE A 361 |
| Chain | Residue |
| A | GLY39 |
| A | GLY40 |
| A | LYS66 |
| A | LYS78 |
| A | PRO117 |
| A | ASP118 |
| A | ASN262 |
| A | ALA292 |
| A | LEU295 |
| A | NAI360 |
| A | HOH1046 |
| A | HOH1226 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PHE B 761 |
| Chain | Residue |
| B | GLY39 |
| B | GLY40 |
| B | MET63 |
| B | LYS66 |
| B | LYS78 |
| B | PRO117 |
| B | ASP118 |
| B | ASN262 |
| B | NAI760 |
| B | HOH1008 |
| B | HOH1073 |
| site_id | BC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAI A 360 |
| Chain | Residue |
| A | ARG42 |
| A | ASP118 |
| A | SER149 |
| A | THR153 |
| A | GLY182 |
| A | LEU183 |
| A | GLY184 |
| A | ALA185 |
| A | VAL186 |
| A | ASP205 |
| A | THR206 |
| A | LEU224 |
| A | CYS238 |
| A | ALA239 |
| A | ALA260 |
| A | ALA261 |
| A | ASN262 |
| A | ASN288 |
| A | PHE361 |
| A | HOH1082 |
| A | HOH1149 |
| A | HOH1163 |
| A | HOH1281 |
| A | HOH1488 |
| A | HOH1493 |
| A | HOH1786 |
| A | HOH1867 |
| site_id | BC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAI B 760 |
| Chain | Residue |
| B | GLY184 |
| B | ALA185 |
| B | VAL186 |
| B | ASP205 |
| B | THR206 |
| B | ARG210 |
| B | CYS238 |
| B | ALA239 |
| B | MET240 |
| B | ALA260 |
| B | ALA261 |
| B | ASN262 |
| B | ASN288 |
| B | PHE761 |
| B | HOH1091 |
| B | HOH1123 |
| B | HOH1300 |
| B | HOH1320 |
| B | HOH1498 |
| B | ARG42 |
| B | ASP118 |
| B | SER149 |
| B | THR153 |
| B | GLY182 |
| B | LEU183 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA B 860 |
| Chain | Residue |
| A | THR15 |
| B | ARG28 |
| B | HOH1062 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:10924111 |
| Chain | Residue | Details |
| B | LYS78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1C1D |
| Chain | Residue | Details |
| B | ARG42 | |
| B | LYS66 | |
| B | PRO117 | |
| B | ASN262 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D, ECO:0007744|PDB:1C1X |
| Chain | Residue | Details |
| B | ASP118 | |
| B | SER149 | |
| B | THR153 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0000305, ECO:0007744|PDB:1BW9, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D |
| Chain | Residue | Details |
| B | GLY182 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1BW9, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D |
| Chain | Residue | Details |
| B | ASP205 | |
| B | ARG210 | |
| B | ALA239 | |
| B | ALA260 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hrd |
| Chain | Residue | Details |
| A | ASP118 | |
| A | LYS78 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hrd |
| Chain | Residue | Details |
| B | ASP118 | |
| B | LYS78 |
