1C1D
L-PHENYLALANINE DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NADH AND L-PHENYLALANINE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006559 | biological_process | L-phenylalanine catabolic process |
A | 0009094 | biological_process | L-phenylalanine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
A | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0006559 | biological_process | L-phenylalanine catabolic process |
B | 0009094 | biological_process | L-phenylalanine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
B | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 850 |
Chain | Residue |
A | ASP118 |
A | THR121 |
A | HOH1493 |
A | HOH1602 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K B 851 |
Chain | Residue |
B | HOH1194 |
B | HOH1421 |
B | LEU170 |
B | SER172 |
B | ASP174 |
B | LEU176 |
B | PO4880 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K B 852 |
Chain | Residue |
B | ASP118 |
B | THR121 |
B | HOH1320 |
B | HOH1452 |
B | HOH1667 |
B | HOH1746 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 853 |
Chain | Residue |
A | VAL136 |
A | PHE137 |
A | GLY138 |
A | ARG139 |
A | GLY145 |
A | GLU299 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA B 854 |
Chain | Residue |
B | ASP30 |
B | HOH1094 |
B | HOH1140 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 855 |
Chain | Residue |
B | GLN200 |
B | LEU201 |
B | HIS219 |
B | HOH1067 |
B | HOH1754 |
site_id | AC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PO4 B 880 |
Chain | Residue |
B | SER1 |
B | SER4 |
B | THR54 |
B | LYS58 |
B | LEU170 |
B | LEU176 |
B | K851 |
B | HOH1106 |
B | HOH1168 |
B | HOH1421 |
B | HOH1456 |
B | HOH1510 |
site_id | AC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PHE A 361 |
Chain | Residue |
A | GLY39 |
A | GLY40 |
A | LYS66 |
A | LYS78 |
A | PRO117 |
A | ASP118 |
A | ASN262 |
A | ALA292 |
A | LEU295 |
A | NAI360 |
A | HOH1046 |
A | HOH1226 |
site_id | AC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE PHE B 761 |
Chain | Residue |
B | GLY39 |
B | GLY40 |
B | MET63 |
B | LYS66 |
B | LYS78 |
B | PRO117 |
B | ASP118 |
B | ASN262 |
B | NAI760 |
B | HOH1008 |
B | HOH1073 |
site_id | BC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAI A 360 |
Chain | Residue |
A | ARG42 |
A | ASP118 |
A | SER149 |
A | THR153 |
A | GLY182 |
A | LEU183 |
A | GLY184 |
A | ALA185 |
A | VAL186 |
A | ASP205 |
A | THR206 |
A | LEU224 |
A | CYS238 |
A | ALA239 |
A | ALA260 |
A | ALA261 |
A | ASN262 |
A | ASN288 |
A | PHE361 |
A | HOH1082 |
A | HOH1149 |
A | HOH1163 |
A | HOH1281 |
A | HOH1488 |
A | HOH1493 |
A | HOH1786 |
A | HOH1867 |
site_id | BC2 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NAI B 760 |
Chain | Residue |
B | GLY184 |
B | ALA185 |
B | VAL186 |
B | ASP205 |
B | THR206 |
B | ARG210 |
B | CYS238 |
B | ALA239 |
B | MET240 |
B | ALA260 |
B | ALA261 |
B | ASN262 |
B | ASN288 |
B | PHE761 |
B | HOH1091 |
B | HOH1123 |
B | HOH1300 |
B | HOH1320 |
B | HOH1498 |
B | ARG42 |
B | ASP118 |
B | SER149 |
B | THR153 |
B | GLY182 |
B | LEU183 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE IPA B 860 |
Chain | Residue |
A | THR15 |
B | ARG28 |
B | HOH1062 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:10924111 |
Chain | Residue | Details |
B | LYS78 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1C1D |
Chain | Residue | Details |
B | ARG42 | |
B | LYS66 | |
B | PRO117 | |
B | ASN262 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D, ECO:0007744|PDB:1C1X |
Chain | Residue | Details |
B | ASP118 | |
B | SER149 | |
B | THR153 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0000305, ECO:0007744|PDB:1BW9, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D |
Chain | Residue | Details |
B | GLY182 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10924111, ECO:0007744|PDB:1BW9, ECO:0007744|PDB:1BXG, ECO:0007744|PDB:1C1D |
Chain | Residue | Details |
B | ASP205 | |
B | ARG210 | |
B | ALA239 | |
B | ALA260 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hrd |
Chain | Residue | Details |
A | ASP118 | |
A | LYS78 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hrd |
Chain | Residue | Details |
B | ASP118 | |
B | LYS78 |