1C0E
Active Site S19A Mutant of Bovine Heart Phosphotyrosyl Phosphatase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003993 | molecular_function | acid phosphatase activity |
A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016791 | molecular_function | phosphatase activity |
B | 0003993 | molecular_function | acid phosphatase activity |
B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
B | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006470 | biological_process | protein dephosphorylation |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 158 |
Chain | Residue |
A | CYS12 |
A | LEU13 |
A | GLY14 |
A | ASN15 |
A | ILE16 |
A | CYS17 |
A | ARG18 |
A | ASP129 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 B 358 |
Chain | Residue |
B | CYS212 |
B | LEU213 |
B | GLY214 |
B | ASN215 |
B | ILE216 |
B | CYS217 |
B | ARG218 |
B | ASP329 |
B | HOH65 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:8052313, ECO:0000269|PubMed:8132604, ECO:0000269|PubMed:8319676 |
Chain | Residue | Details |
A | LEU13 | |
B | ILE313 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:8052313, ECO:0000269|PubMed:8319676 |
Chain | Residue | Details |
A | ALA19 | |
B | TYR319 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:8052313 |
Chain | Residue | Details |
A | PRO130 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:2644264 |
Chain | Residue | Details |
A | GLU2 | |
B | LYS302 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P24666 |
Chain | Residue | Details |
A | TYR132 | |
A | GLY133 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 462 |
Chain | Residue | Details |
A | LEU13 | covalent catalysis |
A | ILE16 | activator, electrostatic stabiliser |
A | ARG18 | steric role |
A | ALA19 | transition state stabiliser |
A | PRO20 | activator, electrostatic stabiliser |
A | PRO130 | proton shuttle (general acid/base) |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 462 |
Chain | Residue | Details |
B | ILE313 | covalent catalysis |
B | LEU316 | activator, electrostatic stabiliser |
B | SER318 | steric role |
B | TYR319 | transition state stabiliser |
B | ASP320 | activator, electrostatic stabiliser |