1BX4

STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004001	molecular_function	adenosine kinase activity
A	0004136	molecular_function	deoxyadenosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0006170	biological_process	dAMP biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032261	biological_process	purine nucleotide salvage
A	0044209	biological_process	AMP salvage
A	0046872	molecular_function	metal ion binding
A	0110052	biological_process	toxic metabolite repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 380

Chain	Residue
A	ASN14
A	THR66
A	ADN350

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 385

Chain	Residue
A	THR265
A	HOH556
A	HOH746

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 360

Chain	Residue
A	HOH747
A	HOH748
A	HOH749
A	HOH750
A	HOH751
A	HOH746

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 365

Chain	Residue
A	ASP130
A	ASN131
A	HOH752
A	HOH753
A	HOH754
A	HOH755

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 375

Chain	Residue
A	SER32
A	HOH402
A	HOH756
A	HOH757
A	HOH758
A	HOH759

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADN A 350

Chain	Residue
A	ASN14
A	ASP18
A	LEU40
A	GLY64
A	SER65
A	ASN68
A	PHE170
A	ASN296
A	GLY297
A	ASP300
A	CL380
A	HOH415
A	HOH416
A	HOH430

---

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADN A 355

Chain	Residue
A	THR265
A	GLY267
A	ARG268
A	THR271
A	ASP286
A	GLN289
A	ILE292
A	ALA298
A	GLY299
A	HIS324
A	ALA327
A	ILE331
A	HOH408
A	HOH410
A	HOH420
A	HOH425
A	HOH577
A	HOH597
A	HOH637

---

site_id	ADA
Number of Residues	1
Details	ADN 350 BINDS IN THE SUBSTRATE BINDING SITE.

Chain	Residue
A	ADN350

---

site_id	ADB
Number of Residues	1
Details	ADN 355 BINDS IN THE ATP BINDING SITE.

Chain	Residue
A	ADN355

---

Functional Information from PROSITE/UniProt

site_id	PS00584
Number of Residues	14
Details	PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL

Chain	Residue	Details
A	ASP294-LEU307

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"12112843","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1lio

Chain	Residue	Details
A	ASP300
A	ARG132

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1lio

Chain	Residue	Details
A	ALA298
A	ASP300
A	GLY297
A	GLY299

---