1BWP

PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0007283	biological_process	spermatogenesis
A	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046982	molecular_function	protein heterodimerization activity
A	0047179	molecular_function	platelet-activating factor acetyltransferase activity

Functional Information from PDB Data

site_id	ZNB
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
A	SER47
A	ASP192
A	HIS195

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:8985254, ECO:0007744|PDB:1BWP

Chain	Residue	Details
A	SER47
A	ASP192
A	HIS195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q15102

Chain	Residue	Details
A	SER2

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 94

Chain	Residue	Details
A	SER47	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLY74	electrostatic stabiliser, hydrogen bond donor
A	ASN104	electrostatic stabiliser, hydrogen bond donor
A	ASP192	activator, electrostatic stabiliser, hydrogen bond acceptor
A	HIS195	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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