1BW9
PHENYLALANINE DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NAD+ AND PHENYLPYRUVATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| A | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
| A | 0170033 | biological_process | L-amino acid metabolic process |
| A | 0170039 | biological_process | proteinogenic amino acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| B | 0050175 | molecular_function | phenylalanine dehydrogenase activity |
| B | 0170033 | biological_process | L-amino acid metabolic process |
| B | 0170039 | biological_process | proteinogenic amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 850 |
| Chain | Residue |
| A | ASP118 |
| A | THR121 |
| A | HOH656 |
| A | HOH728 |
| B | HOH884 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 851 |
| Chain | Residue |
| B | HOH1227 |
| B | HOH1319 |
| A | HOH371 |
| A | HOH436 |
| B | ASP409 |
| B | HOH1100 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 852 |
| Chain | Residue |
| B | GLN600 |
| B | GLY618 |
| B | HOH1008 |
| B | HOH1083 |
| B | HOH1326 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 853 |
| Chain | Residue |
| B | LEU570 |
| B | SER572 |
| B | ASP574 |
| B | LEU576 |
| B | PO4880 |
| B | HOH993 |
| B | HOH1140 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 B 880 |
| Chain | Residue |
| B | SER401 |
| B | SER404 |
| B | LYS458 |
| B | LEU570 |
| B | LEU576 |
| B | K853 |
| B | HOH1019 |
| B | HOH1038 |
| B | HOH1140 |
| B | HOH1157 |
| B | HOH1204 |
| site_id | AC6 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD A 360 |
| Chain | Residue |
| A | LYS66 |
| A | LYS78 |
| A | PRO117 |
| A | ASP118 |
| A | VAL119 |
| A | GLY182 |
| A | GLY184 |
| A | ALA185 |
| A | VAL186 |
| A | ALA204 |
| A | ASP205 |
| A | THR206 |
| A | ARG210 |
| A | LEU224 |
| A | CYS238 |
| A | ALA239 |
| A | MET240 |
| A | ALA260 |
| A | ALA261 |
| A | ASN262 |
| A | PPY361 |
| A | HOH394 |
| A | HOH395 |
| A | HOH446 |
| A | HOH493 |
| A | HOH521 |
| A | HOH552 |
| A | HOH656 |
| A | HOH761 |
| A | HOH771 |
| B | EDO874 |
| B | HOH881 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PPY A 361 |
| Chain | Residue |
| A | GLY39 |
| A | GLY40 |
| A | MET63 |
| A | LYS66 |
| A | LYS78 |
| A | GLY116 |
| A | PRO117 |
| A | GLY291 |
| A | ALA292 |
| A | LEU295 |
| A | NAD360 |
| A | HOH414 |
| B | HOH882 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAD B 760 |
| Chain | Residue |
| B | LEU583 |
| B | GLY584 |
| B | ALA585 |
| B | VAL586 |
| B | ASP605 |
| B | THR606 |
| B | ARG610 |
| B | HOH905 |
| B | HOH907 |
| B | HOH935 |
| B | HOH1044 |
| B | HOH1239 |
| B | HOH1381 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PPY B 761 |
| Chain | Residue |
| B | PRO517 |
| A | HOH382 |
| B | GLY439 |
| B | GLY440 |
| B | MET463 |
| B | LYS466 |
| B | LYS478 |
| B | GLY516 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 871 |
| Chain | Residue |
| B | MET474 |
| B | IPA861 |
| B | HOH1193 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 873 |
| Chain | Residue |
| A | HOH600 |
| B | HOH887 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 874 |
| Chain | Residue |
| A | SER149 |
| A | ALA150 |
| A | THR153 |
| A | VAL186 |
| A | NAD360 |
| B | HOH881 |
| B | HOH882 |
| B | HOH884 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA B 860 |
| Chain | Residue |
| A | CYS232 |
| A | ASP253 |
| A | CYS254 |
| A | SER255 |
| A | HOH610 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA B 861 |
| Chain | Residue |
| A | ALA276 |
| B | LEU434 |
| B | PRO473 |
| B | EDO871 |
| B | HOH1071 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IPA B 862 |
| Chain | Residue |
| B | ARG442 |
| B | ASP455 |
| B | LYS458 |
| B | LEU459 |
| B | ASN663 |
| B | HOH1123 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA B 863 |
| Chain | Residue |
| A | THR15 |
| A | LEU49 |
| B | LEU406 |
| B | ARG428 |
| B | HOH985 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10924111","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10924111","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C1D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10924111","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C1X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10924111","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1BW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C1D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10924111","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C1D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hrd |
| Chain | Residue | Details |
| A | ASP118 | |
| A | LYS78 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hrd |
| Chain | Residue | Details |
| B | ASP518 | |
| B | LYS478 |
