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1BW5

THE NMR SOLUTION STRUCTURE OF THE HOMEODOMAIN OF THE RAT INSULIN GENE ENHANCER PROTEIN ISL-1, 50 STRUCTURES

Functional Information from GO Data
ChainGOidnamespacecontents
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0003677molecular_functionDNA binding
A0006355biological_processregulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048665biological_processneuron fate specification
Functional Information from PROSITE/UniProt
site_idPS00027
Number of Residues24
DetailsHOMEOBOX_1 'Homeobox' domain signature. LVemTgLSprVIRVWFqNkrckdK
ChainResidueDetails
ALEU36-LYS59

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues59
DetailsDNA binding: {"description":"Homeobox","evidences":[{"source":"PROSITE-ProRule","id":"PRU00108","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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