1BVH
SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003993 | molecular_function | acid phosphatase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0030946 | molecular_function | protein tyrosine phosphatase activity, metal-dependent |
| A | 0140793 | molecular_function | histone H2AXY142 phosphatase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:8052313, ECO:0000269|PubMed:8132604, ECO:0000269|PubMed:8319676 |
| Chain | Residue | Details |
| A | LEU13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:8052313, ECO:0000269|PubMed:8319676 |
| Chain | Residue | Details |
| A | SER19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:8052313 |
| Chain | Residue | Details |
| A | PRO130 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:2644264 |
| Chain | Residue | Details |
| A | GLU2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P24666 |
| Chain | Residue | Details |
| A | TYR132 | |
| A | GLY133 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pnt |
| Chain | Residue | Details |
| A | CYS17 | |
| A | ARG18 | |
| A | ASP129 | |
| A | CYS12 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 462 |
| Chain | Residue | Details |
| A | LEU13 | covalent catalysis |
| A | ILE16 | activator, electrostatic stabiliser |
| A | ARG18 | steric role |
| A | SER19 | transition state stabiliser |
| A | PRO20 | activator, electrostatic stabiliser |
| A | PRO130 | proton shuttle (general acid/base) |
