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1BUY

HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001666biological_processresponse to hypoxia
A0005125molecular_functioncytokine activity
A0005128molecular_functionerythropoietin receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006357biological_processregulation of transcription by RNA polymerase II
A0006915biological_processapoptotic process
A0006953biological_processacute-phase response
A0007165biological_processsignal transduction
A0007566biological_processembryo implantation
A0007584biological_processresponse to nutrient
A0008015biological_processblood circulation
A0008284biological_processpositive regulation of cell population proliferation
A0009651biological_processresponse to salt stress
A0009986cellular_componentcell surface
A0010523biological_processnegative regulation of calcium ion transport into cytosol
A0010976biological_processpositive regulation of neuron projection development
A0030218biological_processerythrocyte differentiation
A0030295molecular_functionprotein kinase activator activity
A0032496biological_processresponse to lipopolysaccharide
A0033028biological_processmyeloid cell apoptotic process
A0033033biological_processnegative regulation of myeloid cell apoptotic process
A0033189biological_processresponse to vitamin A
A0033574biological_processresponse to testosterone
A0038162biological_processerythropoietin-mediated signaling pathway
A0042104biological_processpositive regulation of activated T cell proliferation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042541biological_processhemoglobin biosynthetic process
A0043066biological_processnegative regulation of apoptotic process
A0043249biological_processerythrocyte maturation
A0043627biological_processresponse to estrogen
A0044297cellular_componentcell body
A0045666biological_processpositive regulation of neuron differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046579biological_processpositive regulation of Ras protein signal transduction
A0048678biological_processresponse to axon injury
A0051602biological_processresponse to electrical stimulus
A0055093biological_processresponse to hyperoxia
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070555biological_processresponse to interleukin-1
A0071474biological_processcellular hyperosmotic response
A0071548biological_processresponse to dexamethasone
A1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
A1902251biological_processnegative regulation of erythrocyte apoptotic process
A2001258biological_processnegative regulation of cation channel activity
Functional Information from PROSITE/UniProt
site_idPS00817
Number of Residues28
DetailsEPO_TPO Erythropoietin / thrombopoeitin signature. PprliCDsRVLeRylleakeaekittgC
ChainResidueDetails
APRO2-CYS29

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3949763
ChainResidueDetails
ALYS24
ALYS38
ALYS83

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:3949763
ChainResidueDetails
ASER126

222624

PDB entries from 2024-07-17

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