Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0005576 | cellular_component | extracellular region |
| C | 0031639 | biological_process | plasminogen activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0GJ A 246 |
| Chain | Residue |
| A | CYS191 |
| A | GLN192 |
| A | GLY193 |
| A | SER195 |
| A | SER214 |
| A | TRP215 |
| A | GLY216 |
| A | GLY219 |
| B | LYS10 |
| C | HIS43 |
| A | HIS57 |
| A | ASP189 |
| A | SER190 |
| site_id | ASA |
| Number of Residues | 3 |
| Details | CATALYTIC SITE OF CHAIN A |
| Chain | Residue |
| A | SER195 |
| A | HIS57 |
| A | ASP102 |
| site_id | ASB |
| Number of Residues | 3 |
| Details | CATALYTIC SITE OF CHAIN B |
| Chain | Residue |
| B | SER195 |
| B | HIS57 |
| B | ASP102 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| A | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by plasminogen activator |
| Chain | Residue | Details |
| A | ARG15 | |
| B | ARG15 | |
| Chain | Residue | Details |
| A | SER32 | |
| B | SER32 | |
| Chain | Residue | Details |
| A | SER125 | |
| B | SER125 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS57 | proton shuttle (general acid/base) |
| A | ASP102 | electrostatic stabiliser, modifies pKa |
| A | SER195 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY196 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| B | HIS57 | proton shuttle (general acid/base) |
| B | ASP102 | electrostatic stabiliser, modifies pKa |
| B | SER195 | covalent catalysis, proton shuttle (general acid/base) |
| B | GLY196 | electrostatic stabiliser |
