Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004097 | molecular_function | catechol oxidase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0004097 | molecular_function | catechol oxidase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU A 500 |
| Chain | Residue |
| A | HIS88 |
| A | HIS109 |
| A | HIS118 |
| A | URS1002 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU A 501 |
| Chain | Residue |
| A | HIS240 |
| A | HIS244 |
| A | HIS274 |
| A | URS1002 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU B 500 |
| Chain | Residue |
| B | HIS88 |
| B | HIS109 |
| B | HIS118 |
| B | URS1002 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU B 501 |
| Chain | Residue |
| B | HIS240 |
| B | HIS244 |
| B | HIS274 |
| B | URS1002 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE URS A 1002 |
| Chain | Residue |
| A | HIS88 |
| A | HIS109 |
| A | HIS118 |
| A | HIS240 |
| A | HIS244 |
| A | MET258 |
| A | GLY259 |
| A | ASN260 |
| A | PHE261 |
| A | HIS274 |
| A | CU500 |
| A | CU501 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE URS B 1002 |
| Chain | Residue |
| B | HIS88 |
| B | HIS109 |
| B | HIS118 |
| B | HIS240 |
| B | HIS244 |
| B | MET258 |
| B | GLY259 |
| B | ASN260 |
| B | PHE261 |
| B | HIS274 |
| B | CU500 |
| B | CU501 |
| site_id | CU1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR COPPER A IN MONOMER A |
| Chain | Residue |
| A | HIS88 |
| A | HIS109 |
| A | HIS118 |
| site_id | CU2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR COPPER A IN MONOMER B |
| Chain | Residue |
| B | HIS88 |
| B | HIS109 |
| B | HIS118 |
| site_id | CU3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR COPPER B IN MONOMER A |
| Chain | Residue |
| A | HIS240 |
| A | HIS244 |
| A | HIS274 |
| site_id | CU4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR COPPER B IN MONOMER B |
| Chain | Residue |
| B | HIS240 |
| B | HIS244 |
| B | HIS274 |
Functional Information from PROSITE/UniProt
| site_id | PS00497 |
| Number of Residues | 18 |
| Details | TYROSINASE_1 Tyrosinase CuA-binding region signature. Hnswl.FFpFHRwyLyfyE |
| Chain | Residue | Details |
| A | HIS109-GLU126 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9846879","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"2'-(S-cysteinyl)-histidine (Cys-His)","evidences":[{"source":"PubMed","id":"9846879","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bt1 |
| Chain | Residue | Details |
| A | GLU236 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bt1 |
| Chain | Residue | Details |
| B | GLU236 | |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 125 |
| Chain | Residue | Details |
| A | HIS88 | metal ligand |
| A | HIS109 | metal ligand |
| A | HIS118 | metal ligand |
| A | HIS240 | metal ligand |
| A | HIS244 | metal ligand |
| A | PHE261 | polar/non-polar interaction, steric role |
| A | HIS274 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 125 |
| Chain | Residue | Details |
| B | HIS88 | metal ligand |
| B | HIS109 | metal ligand |
| B | HIS118 | metal ligand |
| B | HIS240 | metal ligand |
| B | HIS244 | metal ligand |
| B | PHE261 | polar/non-polar interaction, steric role |
| B | HIS274 | metal ligand |
