1BR9

HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008191	molecular_function	metalloendopeptidase inhibitor activity
A	0008270	molecular_function	zinc ion binding
A	0009725	biological_process	response to hormone
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0034097	biological_process	response to cytokine
A	0035580	cellular_component	specific granule lumen
A	0046872	molecular_function	metal ion binding
A	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0140678	molecular_function	molecular function inhibitor activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1905049	biological_process	negative regulation of metallopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00288
Number of Residues	13
Details	TIMP Tissue inhibitors of metalloproteinases signature. CsCsPvHPQqaFC

Chain	Residue	Details
A	CYS1-CYS13

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:24073280, ECO:0007744|PDB:4ILW

Chain	Residue	Details
A	CYS1

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Involved in metalloproteinase-binding => ECO:0000269|PubMed:24073280, ECO:0007744|PDB:4ILW

Chain	Residue	Details
A	ASN14
A	ILE35
A	LYS41

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