1BP3

THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002092	biological_process	positive regulation of receptor internalization
A	0005125	molecular_function	cytokine activity
A	0005131	molecular_function	growth hormone receptor binding
A	0005148	molecular_function	prolactin receptor binding
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008083	molecular_function	growth factor activity
A	0010536	biological_process	positive regulation of activation of Janus kinase activity
A	0010828	biological_process	positive regulation of glucose transmembrane transport
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0031667	biological_process	response to nutrient levels
A	0031904	cellular_component	endosome lumen
A	0032355	biological_process	response to estradiol
A	0040018	biological_process	positive regulation of multicellular organism growth
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0043568	biological_process	positive regulation of insulin-like growth factor receptor signaling pathway
A	0045927	biological_process	positive regulation of growth
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046872	molecular_function	metal ion binding
A	0048513	biological_process	animal organ development
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060396	biological_process	growth hormone receptor signaling pathway
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070186	molecular_function	growth hormone activity
A	0070195	cellular_component	growth hormone receptor complex
A	0070977	biological_process	bone maturation
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	HIS18
A	GLU174
B	ASP387
B	HIS388

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site_id	ZNA
Number of Residues	4
Details	ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR.

Chain	Residue
A	HIS18
A	GLU174
B	ASP387
B	HIS388

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Functional Information from PROSITE/UniProt

site_id	PS00266
Number of Residues	34
Details	SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CfSesIpTPsnreeTqqksnleLlrisllLiqSW

Chain	Residue	Details
A	CYS53-TRP86

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site_id	PS00338
Number of Residues	18
Details	SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CFRkDMdKVEtFlrIvqC

Chain	Residue	Details
A	CYS165-CYS182

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site_id	PS01352
Number of Residues	78
Details	HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdhgy....WsaWspatfI

Chain	Residue	Details
B	LEU323-ILE400

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	209
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
B	GLN201-ASP410
A	GLU174

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	ASP387
B	HIS388

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site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN235
B	ASN280
B	ASN409

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Deamidated asparagine; by deterioration => ECO:0000269|PubMed:7028740

Chain	Residue	Details
A	ASN152

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