Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009314 | biological_process | response to radiation |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE UMP A 603 |
Chain | Residue |
A | CYS168 |
A | ASP169 |
A | ASN177 |
A | HIS207 |
A | TYR209 |
A | HOH792 |
A | HOH837 |
A | ARG21 |
A | ARG126 |
A | ARG127 |
A | CYS146 |
A | HIS147 |
A | GLN165 |
A | ARG166 |
A | SER167 |
site_id | ACT |
Number of Residues | 1 |
Details | ACTIVE SITE REACTIVE THIOL. |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV |
Chain | Residue | Details |
A | ARG126-VAL154 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS146 | |
Chain | Residue | Details |
A | ARG21 | |
A | ARG166 | |
A | ASN177 | |
A | HIS207 | |
Chain | Residue | Details |
A | HIS51 | |
A | ASP169 | |
A | ALA263 | |
Chain | Residue | Details |
A | ARG126 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1b02 |
Chain | Residue | Details |
A | SER180 | |
A | ASN177 | |
A | CYS146 | |
site_id | CSA2 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1b02 |
Chain | Residue | Details |
A | HIS207 | |
A | GLU58 | |
A | ASP169 | |
A | SER167 | |
A | CYS146 | |
A | ASP205 | |