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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1BI9

RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND

Functional Information from GO Data
ChainGOidnamespacecontents
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0001822biological_processkidney development
A0001889biological_processliver development
A0002138biological_processretinoic acid biosynthetic process
A0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005737cellular_componentcytoplasm
A0006081biological_processaldehyde metabolic process
A0007494biological_processmidgut development
A0008285biological_processnegative regulation of cell population proliferation
A0016491molecular_functionoxidoreductase activity
A0016918molecular_functionretinal binding
A0021915biological_processneural tube development
A0021983biological_processpituitary gland development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0042904biological_process9-cis-retinoic acid biosynthetic process
A0048471cellular_componentperinuclear region of cytoplasm
A0051289biological_processprotein homotetramerization
A0071300biological_processcellular response to retinoic acid
B0001758molecular_functionretinal dehydrogenase (NAD+) activity
B0001822biological_processkidney development
B0001889biological_processliver development
B0002138biological_processretinoic acid biosynthetic process
B0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005737cellular_componentcytoplasm
B0006081biological_processaldehyde metabolic process
B0007494biological_processmidgut development
B0008285biological_processnegative regulation of cell population proliferation
B0016491molecular_functionoxidoreductase activity
B0016918molecular_functionretinal binding
B0021915biological_processneural tube development
B0021983biological_processpituitary gland development
B0032355biological_processresponse to estradiol
B0032526biological_processresponse to retinoic acid
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0042904biological_process9-cis-retinoic acid biosynthetic process
B0048471cellular_componentperinuclear region of cytoplasm
B0051289biological_processprotein homotetramerization
B0071300biological_processcellular response to retinoic acid
C0001758molecular_functionretinal dehydrogenase (NAD+) activity
C0001822biological_processkidney development
C0001889biological_processliver development
C0002138biological_processretinoic acid biosynthetic process
C0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005737cellular_componentcytoplasm
C0006081biological_processaldehyde metabolic process
C0007494biological_processmidgut development
C0008285biological_processnegative regulation of cell population proliferation
C0016491molecular_functionoxidoreductase activity
C0016918molecular_functionretinal binding
C0021915biological_processneural tube development
C0021983biological_processpituitary gland development
C0032355biological_processresponse to estradiol
C0032526biological_processresponse to retinoic acid
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0042572biological_processretinol metabolic process
C0042573biological_processretinoic acid metabolic process
C0042904biological_process9-cis-retinoic acid biosynthetic process
C0048471cellular_componentperinuclear region of cytoplasm
C0051289biological_processprotein homotetramerization
C0071300biological_processcellular response to retinoic acid
D0001758molecular_functionretinal dehydrogenase (NAD+) activity
D0001822biological_processkidney development
D0001889biological_processliver development
D0002138biological_processretinoic acid biosynthetic process
D0004028molecular_function3-chloroallyl aldehyde dehydrogenase activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005737cellular_componentcytoplasm
D0006081biological_processaldehyde metabolic process
D0007494biological_processmidgut development
D0008285biological_processnegative regulation of cell population proliferation
D0016491molecular_functionoxidoreductase activity
D0016918molecular_functionretinal binding
D0021915biological_processneural tube development
D0021983biological_processpituitary gland development
D0032355biological_processresponse to estradiol
D0032526biological_processresponse to retinoic acid
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0042572biological_processretinol metabolic process
D0042573biological_processretinoic acid metabolic process
D0042904biological_process9-cis-retinoic acid biosynthetic process
D0048471cellular_componentperinuclear region of cytoplasm
D0051289biological_processprotein homotetramerization
D0071300biological_processcellular response to retinoic acid
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL C 504
ChainResidue
DARG259
DARG259
site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE NAD A 701
ChainResidue
AGLY229
AALA230
APHE243
ASER246
AVAL249
ALEU252
AHOH711
AILE165
AILE166
ATRP168
ALYS192
AALA194
AGLU195
AGLY225
site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE NAD B 702
ChainResidue
BILE165
BILE166
BTRP168
BLYS192
BALA194
BGLU195
BGLY225
BGLY229
BALA230
BPHE243
BSER246
BVAL249
BHOH738
site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE NAD C 703
ChainResidue
CILE165
CTRP168
CLYS192
CALA194
CGLU195
CGLN196
CGLY225
CGLY229
CALA230
CPHE243
CSER246
CVAL249
CILE253
CHOH720
CHOH755
site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE NAD D 704
ChainResidue
DILE165
DILE166
DTRP168
DLYS192
DALA194
DGLU195
DGLY225
DGLY229
DALA230
DPHE243
DSER246
DVAL249
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCTAGS
ChainResidueDetails
APHE295-SER306
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU267-PRO274
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10320326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BI9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O94788","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O94788","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O94788","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
ACYS302
AGLU268
AASN169
site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
BCYS302
BGLU268
BASN169
site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
CCYS302
CGLU268
CASN169
site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
DCYS302
DGLU268
DASN169
site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
ACYS302
ALYS192
AGLU268
AGLU399
site_idCSA6
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
BCYS302
BLYS192
BGLU268
BGLU399
site_idCSA7
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
CCYS302
CLYS192
CGLU268
CGLU399
site_idCSA8
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a4s
ChainResidueDetails
DCYS302
DLYS192
DGLU268
DGLU399

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PDB entries from 2026-03-25

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