1BGY

CYTOCHROME BC1 COMPLEX FROM BOVINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006627	biological_process	obsolete protein processing involved in protein targeting to mitochondrion
A	0016020	cellular_component	membrane
A	0017087	cellular_component	mitochondrial processing peptidase complex
A	0022904	biological_process	respiratory electron transport chain
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0022904	biological_process	respiratory electron transport chain
B	0045275	cellular_component	respiratory chain complex III
B	0046872	molecular_function	metal ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0022904	biological_process	respiratory electron transport chain
F	0045275	cellular_component	respiratory chain complex III
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0021539	biological_process	subthalamus development
G	0021548	biological_process	pons development
G	0021680	biological_process	cerebellar Purkinje cell layer development
G	0021766	biological_process	hippocampus development
G	0021794	biological_process	thalamus development
G	0021854	biological_process	hypothalamus development
G	0021860	biological_process	pyramidal neuron development
G	0022904	biological_process	respiratory electron transport chain
G	0030901	biological_process	midbrain development
G	0045275	cellular_component	respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0016020	cellular_component	membrane
J	0022904	biological_process	respiratory electron transport chain
J	0045275	cellular_component	respiratory chain complex III
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0022904	biological_process	respiratory electron transport chain
K	0045275	cellular_component	respiratory chain complex III
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006627	biological_process	obsolete protein processing involved in protein targeting to mitochondrion
M	0016020	cellular_component	membrane
M	0017087	cellular_component	mitochondrial processing peptidase complex
M	0022904	biological_process	respiratory electron transport chain
M	0032991	cellular_component	protein-containing complex
M	0046872	molecular_function	metal ion binding
N	0004222	molecular_function	metalloendopeptidase activity
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006508	biological_process	proteolysis
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0046872	molecular_function	metal ion binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
O	0008121	molecular_function	quinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0020037	molecular_function	heme binding
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0045275	cellular_component	respiratory chain complex III
O	0046872	molecular_function	metal ion binding
O	0048039	molecular_function	ubiquinone binding
O	1902600	biological_process	proton transmembrane transport
P	0009055	molecular_function	electron transfer activity
P	0020037	molecular_function	heme binding
Q	0008121	molecular_function	quinol-cytochrome-c reductase activity
Q	0016020	cellular_component	membrane
Q	0051537	molecular_function	2 iron, 2 sulfur cluster binding
R	0005743	cellular_component	mitochondrial inner membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0016020	cellular_component	membrane
R	0022904	biological_process	respiratory electron transport chain
R	0045275	cellular_component	respiratory chain complex III
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0016020	cellular_component	membrane
S	0021539	biological_process	subthalamus development
S	0021548	biological_process	pons development
S	0021680	biological_process	cerebellar Purkinje cell layer development
S	0021766	biological_process	hippocampus development
S	0021794	biological_process	thalamus development
S	0021854	biological_process	hypothalamus development
S	0021860	biological_process	pyramidal neuron development
S	0022904	biological_process	respiratory electron transport chain
S	0030901	biological_process	midbrain development
S	0045275	cellular_component	respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	quinol-cytochrome-c reductase activity
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0016020	cellular_component	membrane
V	0022904	biological_process	respiratory electron transport chain
V	0045275	cellular_component	respiratory chain complex III
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0022904	biological_process	respiratory electron transport chain
W	0045275	cellular_component	respiratory chain complex III

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM C 380

Chain	Residue
C	GLN44
C	GLY130
C	TYR131
C	PRO134
C	HIS182
C	PHE183
C	PRO186
C	ILE45
C	GLY48
C	LEU49
C	LEU51
C	ALA52
C	ARG80
C	HIS83
C	THR126

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM C 381

Chain	Residue
C	TRP31
C	GLY34
C	SER35
C	LEU37
C	HIS97
C	ARG100
C	SER106
C	PHE109
C	TRP113
C	GLY116
C	VAL117
C	LEU119
C	LEU120
C	HIS196
C	LEU197
C	LEU200
C	SER205
C	ASN206

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEC D 242

Chain	Residue
D	VAL36
D	CYS37
D	SER39
D	CYS40
D	HIS41
D	LEU113
D	ARG120
D	TYR126
D	PHE153
D	ILE158
D	GLY159
D	MET160
D	ILE164
D	LEU190

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM O 380

Chain	Residue
O	LEU41
O	GLN44
O	ILE45
O	GLY48
O	LEU49
O	LEU51
O	ALA52
O	ARG80
O	HIS83
O	THR126
O	GLY130
O	TYR131
O	PRO134
O	HIS182
O	PHE183
O	PRO186

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM O 381

Chain	Residue
O	TRP31
O	GLY34
O	SER35
O	LEU37
O	GLY38
O	LEU94
O	HIS97
O	ARG100
O	SER106
O	PHE109
O	THR112
O	TRP113
O	GLY116
O	VAL117
O	LEU119
O	LEU120
O	HIS196
O	LEU197
O	LEU200
O	SER205
O	ASN206

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEC P 242

Chain	Residue
P	VAL36
P	CYS37
P	CYS40
P	HIS41
P	ASN105
P	LEU113
P	ARG120
P	TYR126
P	VAL127
P	PHE153
P	ILE158
P	GLY159
P	MET160
P	ILE164
P	LEU190

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FES Q 197

Chain	Residue
Q	CYS139
Q	HIS141
Q	LEU142
Q	GLY143
Q	CYS144
Q	CYS158
Q	CYS160
Q	HIS161
Q	SER163

---

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P31930","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FY0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB77","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	322
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00968","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	551
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	244
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	178
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	202
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	85
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P99028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
Q	HIS161

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
A	GLU60

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
M	GLU60

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
B	ARG70

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ndo

Chain	Residue	Details
N	ARG70

---