1BCY
RECOMBINANT RAT ANNEXIN V, T72K MUTANT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005388 | molecular_function | P-type calcium transporter activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007596 | biological_process | blood coagulation |
| A | 0007599 | biological_process | hemostasis |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0014704 | cellular_component | intercalated disc |
| A | 0017046 | molecular_function | peptide hormone binding |
| A | 0030018 | cellular_component | Z disc |
| A | 0030195 | biological_process | negative regulation of blood coagulation |
| A | 0030425 | cellular_component | dendrite |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0030971 | molecular_function | receptor tyrosine kinase binding |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043204 | cellular_component | perikaryon |
| A | 0043679 | cellular_component | axon terminus |
| A | 0050819 | biological_process | negative regulation of coagulation |
| A | 0051592 | biological_process | response to calcium ion |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071284 | biological_process | cellular response to lead ion |
| A | 0072563 | cellular_component | endothelial microparticle |
| A | 0097066 | biological_process | response to thyroid hormone |
| A | 0097211 | biological_process | cellular response to gonadotropin-releasing hormone |
| A | 1901317 | biological_process | regulation of flagellated sperm motility |
| A | 1902721 | biological_process | negative regulation of prolactin secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | MET26 |
| A | GLY28 |
| A | GLY30 |
| A | GLU70 |
| A | HOH589 |
| A | HOH634 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 402 |
| Chain | Residue |
| A | HOH636 |
| A | LYS68 |
| A | LEU71 |
| A | GLU76 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 407 |
| Chain | Residue |
| A | GLY181 |
| A | LYS184 |
| A | GLY186 |
| A | GLU226 |
| A | HOH510 |
| A | HOH532 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 408 |
| Chain | Residue |
| A | ASP224 |
| A | THR227 |
| A | GLU232 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 410 |
| Chain | Residue |
| A | MET257 |
| A | GLY259 |
| A | ALA260 |
| A | GLY261 |
| A | ASP301 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 450 |
| Chain | Residue |
| A | ARG23 |
| A | GLY28 |
| A | ARG61 |
| A | HOH557 |
| A | HOH634 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdedsilnlLtaRsnaQrqQiaeeFktlfgrdLvndMkselkGkfeklIvaL |
| Chain | Residue | Details |
| A | GLY30-LEU82 | |
| A | GLY102-LEU154 | |
| A | GLY186-VAL238 | |
| A | GLY261-LEU313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Motif: {"description":"[IL]-x-C-x-x-[DE] motif","evidences":[{"source":"UniProtKB","id":"P08758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"7583670","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P08758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P08758","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
