1BBR

THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005576	cellular_component	extracellular region
J	0006508	biological_process	proteolysis
J	0007596	biological_process	blood coagulation
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005509	molecular_function	calcium ion binding
K	0006508	biological_process	proteolysis
K	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005576	cellular_component	extracellular region
M	0006508	biological_process	proteolysis
M	0007596	biological_process	blood coagulation
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005509	molecular_function	calcium ion binding
N	0006508	biological_process	proteolysis
N	0007596	biological_process	blood coagulation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58
K	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
E	ASP189-VAL200
K	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
K	HIS57
K	ASP102
K	SER195
N	HIS57
N	ASP102
N	SER195

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.4

Chain	Residue	Details
K	ASN60
N	ASN60

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	ASP102
K	SER195
K	GLY193
K	HIS57

---

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57
E	SER195
E	GLY196

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	ASP102
K	SER195
K	HIS57

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	ASP102
N	SER195
N	HIS57

---

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	ASP102
K	SER195
K	HIS57
K	GLY196

---

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	ASP102
N	SER195
N	HIS57
N	GLY196

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	ASP102
N	SER195
N	GLY193
N	HIS57

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	ASP102
K	HIS57

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	ASP102
N	HIS57

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	SER195
K	GLY193

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	SER195
N	GLY193

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER195
E	GLY193

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	SER195
K	GLY196

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site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
N	SER195
N	GLY196

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