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STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006954	biological_process	inflammatory response
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030141	cellular_component	secretory granule
A	0031640	biological_process	killing of cells of another organism
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0036335	biological_process	intestinal stem cell homeostasis
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042742	biological_process	defense response to bacterium
A	0046337	biological_process	phosphatidylethanolamine metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046473	biological_process	phosphatidic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050482	biological_process	arachidonate secretion
A	0050729	biological_process	positive regulation of inflammatory response
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	1902563	biological_process	regulation of neutrophil activation

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCVtHDcC

Chain	Residue	Details
A	CYS44-CYS51

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAAaTC

Chain	Residue	Details
A	LEU95-CYS105

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS48
A	ASP99

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:1948070, ECO:0000269|PubMed:7664108, ECO:0000312|PDB:1DB4, ECO:0000312|PDB:1DB5, ECO:0000312|PDB:1DCY, ECO:0000312|PDB:1POE

Chain	Residue	Details
A	HIS28
A	GLY30
A	GLY32
A	ASP49

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important for integrin binding => ECO:0000269|PubMed:18635536

Chain	Residue	Details
A	ARG81
A	ARG108

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	HIS48
A	GLY30
A	ASP99

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