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1B9Y

STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0008283biological_processcell population proliferation
A0016020cellular_componentmembrane
A0030159molecular_functionsignaling receptor complex adaptor activity
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0050909biological_processsensory perception of taste
A0051020molecular_functionGTPase binding
A0060041biological_processretina development in camera-type eye
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0097381cellular_componentphotoreceptor disc membrane
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007602biological_processphototransduction
B0008104biological_processprotein localization
B0016020cellular_componentmembrane
B0031681molecular_functionG-protein beta-subunit binding
B0042462biological_processeye photoreceptor cell development
B0097381cellular_componentphotoreceptor disc membrane
C0001750cellular_componentphotoreceptor outer segment
C0001917cellular_componentphotoreceptor inner segment
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005929cellular_componentcilium
C0007601biological_processvisual perception
C0008277biological_processregulation of G protein-coupled receptor signaling pathway
C0042995cellular_componentcell projection
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GD B 101
ChainResidue
BHOH1
BHOH18
BASP542
BGLU546

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GD C 247
ChainResidue
CGLU161
CGLU218
CHOH249
CHOH250
CHOH253

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GD A 341
ChainResidue
AGLN44
AHOH345
CHOH255

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GD B 104
ChainResidue
BHOH10
BHOH19
BASP542
BGLU546
CGLU206

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GD C 248
ChainResidue
BGLU566
CGLU223

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GD A 342
ChainResidue
ACYS204
AASP228

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsqDgKLIIWDS
ChainResidueDetails
ALEU70-SER84
AILE157-ILE171
ALEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P19632
ChainResidueDetails
CSER73

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphohistidine => ECO:0000269|PubMed:12486123
ChainResidueDetails
AHIS266

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PDB entries from 2025-06-11

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