1B9X
STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001750 | cellular_component | photoreceptor outer segment |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045202 | cellular_component | synapse |
| A | 0051020 | molecular_function | GTPase binding |
| A | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| A | 0071870 | biological_process | cellular response to catecholamine stimulus |
| A | 0097381 | cellular_component | photoreceptor disc membrane |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0031681 | molecular_function | G-protein beta-subunit binding |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| C | 0001750 | cellular_component | photoreceptor outer segment |
| C | 0001917 | cellular_component | photoreceptor inner segment |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0007601 | biological_process | visual perception |
| C | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GD C 247 |
| Chain | Residue |
| C | GLU161 |
| C | GLU218 |
| C | HOH250 |
| C | HOH252 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GD B 102 |
| Chain | Residue |
| B | HOH7 |
| B | ASP542 |
| B | GLU546 |
| C | GLU206 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GD A 341 |
| Chain | Residue |
| A | HOH346 |
| A | HOH347 |
| A | GLN44 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GD B 104 |
| Chain | Residue |
| B | ASP542 |
| B | GLU546 |
| C | GLU206 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GD C 248 |
| Chain | Residue |
| B | GLU566 |
| C | GLU223 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GD A 342 |
| Chain | Residue |
| A | CYS204 |
| A | ASP228 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsqDgKLIIWDS |
| Chain | Residue | Details |
| A | LEU70-SER84 | |
| A | ILE157-ILE171 | |
| A | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"PubMed","id":"12486123","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
