1B7G

GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0006096	biological_process	glycolytic process
O	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
O	0009089	biological_process	lysine biosynthetic process via diaminopimelate
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
O	0047100	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005737	cellular_component	cytoplasm
Q	0006096	biological_process	glycolytic process
Q	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
Q	0009089	biological_process	lysine biosynthetic process via diaminopimelate
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
Q	0047100	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 O 601

Chain	Residue
O	SER138
O	CYS139
O	ASN140
O	ARG166
O	HIS192
O	HIS193
O	HOH617

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 Q 602

Chain	Residue
Q	SER138
Q	CYS139
Q	ASN140
Q	ARG166
Q	HIS192
Q	HIS193
Q	HOH667

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 O 603

Chain	Residue
O	ARG166
O	ARG167
O	HOH661
O	HOH847

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 Q 604

Chain	Residue
Q	ARG166
Q	ARG167

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 O 605

Chain	Residue
O	LYS33
O	THR34
O	SER35
O	HOH777
O	HOH894

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 606

Chain	Residue
Q	LYS33
Q	THR34
Q	SER35
Q	HOH744
Q	HOH745

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 O 607

Chain	Residue
O	PRO186
O	SER191
O	HIS192
O	HOH636
O	HOH728
O	HOH784
O	HOH799

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 608

Chain	Residue
Q	PRO186
Q	SER191
Q	HIS192
Q	HOH736
Q	HOH792

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Q 609

Chain	Residue
O	LYS131
Q	ARG49
Q	PRO66

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 O 610

Chain	Residue
O	THR11
O	LYS172
O	GLU173
O	HOH664
O	HOH688

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 O 611

Chain	Residue
O	LYS111
O	ALA112
O	LYS195
O	HOH645
O	HOH675
O	HOH762
O	HOH839

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 Q 612

Chain	Residue
Q	GLY10
Q	THR11
Q	LYS172
Q	HOH640

---

site_id	CTO
Number of Residues	2
Details	CATALYTIC SITE IN SUBUNIT O

Chain	Residue
O	CYS139
O	HIS219

---

site_id	CTQ
Number of Residues	2
Details	CATALYTIC SITE IN SUBUNIT Q

Chain	Residue
Q	CYS139
Q	HIS219

---

site_id	PIO
Number of Residues	5
Details	INORGANIC PHOSPHATE BINDING SITE IN SUBUNIT Q

Chain	Residue
O	SER138
O	ASN140
O	ARG166
O	HIS192
O	HIS193

---

site_id	PIQ
Number of Residues	5
Details	INORGAINC PHOSPHATE BINDING SITE IN SUBUNIT Q

Chain	Residue
Q	SER138
Q	ASN140
Q	ARG166
Q	HIS192
Q	HIS193

---

site_id	PSO
Number of Residues	2
Details	SUBSTRATE PHOSPHARE BINDING SITE IN SUBUNIT O

Chain	Residue
O	ARG166
O	ARG167

---

site_id	PSQ
Number of Residues	2
Details	SUBSTRATE PHOSPHATE BINDING SITE IN SUBUNIT Q

Chain	Residue
Q	ARG166
Q	ARG167

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. VSCNTTaL

Chain	Residue	Details
O	VAL137-LEU144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
O	CYS139
Q	CYS139

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
O	THR11
Q	ARG167
Q	HIS193
Q	GLN300
O	GLY109
O	SER138
O	ARG167
O	HIS193
O	GLN300
Q	THR11
Q	GLY109
Q	SER138

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
O	CYS139
O	HIS219

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
Q	CYS139
Q	HIS219

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
O	ARG166
O	CYS139

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
Q	ARG166
Q	CYS139

---