1B6S
STRUCTURE OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1101 |
| Chain | Residue |
| A | HIS184 |
| A | GLU226 |
| A | GLU238 |
| A | ADP1100 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1201 |
| Chain | Residue |
| B | GLU226 |
| B | GLU238 |
| B | ADP1200 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1301 |
| Chain | Residue |
| C | ADP1300 |
| C | GLU226 |
| C | GLU238 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 1401 |
| Chain | Residue |
| D | GLU226 |
| D | GLU238 |
| D | ADP1400 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP A 1100 |
| Chain | Residue |
| A | ARG80 |
| A | LYS120 |
| A | GLN131 |
| A | GLU153 |
| A | GLN154 |
| A | ILE156 |
| A | PHE158 |
| A | GLU161 |
| A | HIS184 |
| A | PHE228 |
| A | ASN237 |
| A | GLU238 |
| A | MG1101 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP B 1200 |
| Chain | Residue |
| B | ARG80 |
| B | ILE118 |
| B | LYS120 |
| B | GLY125 |
| B | TYR126 |
| B | ASP127 |
| B | GLY128 |
| B | GLN131 |
| B | ARG133 |
| B | GLU153 |
| B | GLN154 |
| B | ILE156 |
| B | PHE158 |
| B | GLU161 |
| B | HIS184 |
| B | PHE228 |
| B | ASN237 |
| B | GLU238 |
| B | MG1201 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP C 1300 |
| Chain | Residue |
| C | ARG80 |
| C | ILE118 |
| C | LYS120 |
| C | GLN131 |
| C | GLU153 |
| C | GLN154 |
| C | ILE156 |
| C | PHE158 |
| C | GLU161 |
| C | HIS184 |
| C | PHE228 |
| C | ASN237 |
| C | GLU238 |
| C | MG1301 |
| C | HOH2471 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP D 1400 |
| Chain | Residue |
| D | ARG80 |
| D | LYS120 |
| D | GLN131 |
| D | ARG133 |
| D | GLU153 |
| D | GLN154 |
| D | ILE156 |
| D | PHE158 |
| D | GLU161 |
| D | HIS184 |
| D | PHE228 |
| D | ASN237 |
| D | GLU238 |
| D | MG1401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 |
| Chain | Residue | Details |
| A | ARG80 | |
| B | HIS184 | |
| B | ASN237 | |
| C | ARG80 | |
| C | LYS120 | |
| C | GLY125 | |
| C | GLU153 | |
| C | GLU161 | |
| C | HIS184 | |
| C | ASN237 | |
| D | ARG80 | |
| D | LYS120 | |
| D | GLY125 | |
| D | GLU153 | |
| D | GLU161 | |
| D | HIS184 | |
| D | ASN237 | |
| A | LYS120 | |
| A | GLY125 | |
| A | GLU153 | |
| A | GLU161 | |
| A | HIS184 | |
| A | ASN237 | |
| B | ARG80 | |
| B | LYS120 | |
| B | GLY125 | |
| B | GLU153 | |
| B | GLU161 |
