1B6B
MELATONIN BIOSYNTHESIS: THE STRUCTURE OF SEROTONIN N-ACETYLTRANSFERASE AT 2.5 A RESOLUTION SUGGESTS A CATALYTIC MECHANISM
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11336675, ECO:0000269|PubMed:11884405, ECO:0000269|PubMed:11902838 |
| Chain | Residue | Details |
| A | LEU124 | |
| A | MET159 | |
| B | LEU124 | |
| B | MET159 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10319816, ECO:0000269|PubMed:11336675, ECO:0000269|PubMed:11902838 |
| Chain | Residue | Details |
| A | GLN132 | |
| A | TYR168 | |
| B | GLN132 | |
| B | TYR168 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Important for the catalytic mechanism; involved in substrate deprotonation => ECO:0000269|PubMed:10319816, ECO:0000269|PubMed:11884405 |
| Chain | Residue | Details |
| A | HIS120 | |
| A | HIS122 | |
| B | HIS120 | |
| B | HIS122 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:11427721, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15644438 |
| Chain | Residue | Details |
| A | THR31 | |
| B | THR31 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 10024876 |
| Chain | Residue | Details |
| B | SER97 | |
| B | LEU111 | |
| B | HIS122 | |
| B | LEU124 | |
| B | TYR168 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 10024876 |
| Chain | Residue | Details |
| A | SER97 | |
| A | LEU111 | |
| A | HIS122 | |
| A | LEU124 | |
| A | TYR168 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 22 |
| Chain | Residue | Details |
| A | SER97 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | LEU111 | hydrogen bond acceptor, steric role |
| A | HIS122 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LEU124 | electrostatic stabiliser, hydrogen bond donor |
| A | TYR168 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 22 |
| Chain | Residue | Details |
| B | SER97 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | LEU111 | hydrogen bond acceptor, steric role |
| B | HIS122 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | LEU124 | electrostatic stabiliser, hydrogen bond donor |
| B | TYR168 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
