1B5E
DCMP HYDROXYMETHYLASE FROM T4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0047153 | molecular_function | deoxycytidylate 5-hydroxymethyltransferase activity |
| A | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0099018 | biological_process | symbiont-mediated evasion of host restriction-modification system |
| B | 0016740 | molecular_function | transferase activity |
| B | 0047153 | molecular_function | deoxycytidylate 5-hydroxymethyltransferase activity |
| B | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| B | 0099018 | biological_process | symbiont-mediated evasion of host restriction-modification system |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DCM A 300 |
| Chain | Residue |
| A | GLY175 |
| A | ASP179 |
| A | HIS216 |
| A | TYR218 |
| A | HOH303 |
| A | HOH315 |
| B | ARG123 |
| B | ARG124 |
| A | LYS28 |
| A | TYR96 |
| A | CYS148 |
| A | ARG168 |
| A | SER169 |
| A | ASN170 |
| A | ASP171 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DCM B 400 |
| Chain | Residue |
| A | ARG123 |
| A | ARG124 |
| B | LYS28 |
| B | TYR96 |
| B | CYS148 |
| B | ARG168 |
| B | SER169 |
| B | ASN170 |
| B | ASP171 |
| B | GLY175 |
| B | ASP179 |
| B | HIS216 |
| B | TYR218 |
| B | HOH401 |
| B | HOH403 |
| B | HOH415 |
| site_id | CAT |
| Number of Residues | 2 |
| Details | THE SG ATOM OF CYS 148 HAS DUAL CONFORMATION |
| Chain | Residue |
| A | CYS148 |
| B | CYS148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1420151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1420151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| A | ASP179 | |
| A | GLN183 | |
| A | CYS148 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| B | ASP179 | |
| B | GLN183 | |
| B | CYS148 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 700 |
| Chain | Residue | Details |
| A | GLU60 | electrostatic stabiliser, proton acceptor, proton donor |
| A | CYS148 | covalently attached, nucleofuge, nucleophile |
| A | ASP179 | electrostatic stabiliser, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 700 |
| Chain | Residue | Details |
| B | GLU60 | electrostatic stabiliser, proton acceptor, proton donor |
| B | CYS148 | covalently attached, nucleofuge, nucleophile |
| B | ASP179 | electrostatic stabiliser, proton acceptor, proton donor |
