1B55
PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | HIS143 |
| A | CYS154 |
| A | CYS155 |
| A | CYS165 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 171 |
| Chain | Residue |
| B | TYR142 |
| B | HIS143 |
| B | CYS154 |
| B | CYS155 |
| B | CYS165 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 4IP A 171 |
| Chain | Residue |
| A | LYS12 |
| A | SER14 |
| A | GLN15 |
| A | GLN16 |
| A | LYS17 |
| A | LYS18 |
| A | LYS18 |
| A | SER21 |
| A | PRO22 |
| A | ASN24 |
| A | ARG28 |
| A | TYR39 |
| A | LYS53 |
| A | LYS53 |
| A | HOH197 |
| A | HOH222 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 4IP B 172 |
| Chain | Residue |
| B | LYS12 |
| B | SER14 |
| B | GLN15 |
| B | GLN16 |
| B | LYS17 |
| B | LYS18 |
| B | LYS18 |
| B | SER21 |
| B | ASN24 |
| B | ARG28 |
| B | TYR39 |
| B | LYS53 |
| B | LYS53 |
| B | HOH185 |
| B | HOH187 |
| B | HOH222 |
| site_id | ZN1 |
| Number of Residues | 5 |
| Details | ZN BINDING SITE IN THE BTK MOTIF, CHAIN A. |
| Chain | Residue |
| A | ZN1 |
| A | HIS143 |
| A | CYS154 |
| A | CYS155 |
| A | CYS165 |
| site_id | ZN2 |
| Number of Residues | 5 |
| Details | ZN BINDING SITE IN THE BTK MOTIF, CHAIN B. |
| Chain | Residue |
| B | CYS165 |
| B | ZN171 |
| B | HIS143 |
| B | CYS154 |
| B | CYS155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Inositol-(1,3,4,5)-tetrakisphosphate 1-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00432","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10196129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9218782","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of PH domain of Bruton's tyrosine kinase.","authors":["Murayama K.","Kato-Murayama M.","Mishima C.","Shirouzu M.","Yokoyama S."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16644721","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P35991","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
