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1B53

NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001649biological_processosteoblast differentiation
A0001775biological_processcell activation
A0002548biological_processmonocyte chemotaxis
A0004672molecular_functionprotein kinase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007010biological_processcytoskeleton organization
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0008360biological_processregulation of cell shape
A0009636biological_processresponse to toxic substance
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010818biological_processT cell chemotaxis
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0016004molecular_functionphospholipase activator activity
A0016301molecular_functionkinase activity
A0019722biological_processcalcium-mediated signaling
A0023052biological_processsignaling
A0030335biological_processpositive regulation of cell migration
A0030502biological_processnegative regulation of bone mineralization
A0030593biological_processneutrophil chemotaxis
A0031726molecular_functionCCR1 chemokine receptor binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0042056molecular_functionchemoattractant activity
A0042802molecular_functionidentical protein binding
A0043308biological_processeosinophil degranulation
A0043525biological_processpositive regulation of neuron apoptotic process
A0043615biological_processastrocyte cell migration
A0043922biological_processnegative regulation by host of viral transcription
A0045671biological_processnegative regulation of osteoclast differentiation
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048246biological_processmacrophage chemotaxis
A0048247biological_processlymphocyte chemotaxis
A0050729biological_processpositive regulation of inflammatory response
A0050795biological_processregulation of behavior
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050918biological_processpositive chemotaxis
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051928biological_processpositive regulation of calcium ion transport
A0051930biological_processregulation of sensory perception of pain
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070723biological_processresponse to cholesterol
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071621biological_processgranulocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A1903980biological_processpositive regulation of microglial cell activation
A1904141biological_processpositive regulation of microglial cell migration
A2000503biological_processpositive regulation of natural killer cell chemotaxis
B0000165biological_processMAPK cascade
B0001649biological_processosteoblast differentiation
B0001775biological_processcell activation
B0002548biological_processmonocyte chemotaxis
B0004672molecular_functionprotein kinase activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006887biological_processexocytosis
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007010biological_processcytoskeleton organization
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0008360biological_processregulation of cell shape
B0009636biological_processresponse to toxic substance
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010818biological_processT cell chemotaxis
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0016004molecular_functionphospholipase activator activity
B0016301molecular_functionkinase activity
B0019722biological_processcalcium-mediated signaling
B0023052biological_processsignaling
B0030335biological_processpositive regulation of cell migration
B0030502biological_processnegative regulation of bone mineralization
B0030593biological_processneutrophil chemotaxis
B0031726molecular_functionCCR1 chemokine receptor binding
B0031730molecular_functionCCR5 chemokine receptor binding
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0042056molecular_functionchemoattractant activity
B0042802molecular_functionidentical protein binding
B0043308biological_processeosinophil degranulation
B0043525biological_processpositive regulation of neuron apoptotic process
B0043615biological_processastrocyte cell migration
B0043922biological_processnegative regulation by host of viral transcription
B0045671biological_processnegative regulation of osteoclast differentiation
B0048020molecular_functionCCR chemokine receptor binding
B0048245biological_processeosinophil chemotaxis
B0048246biological_processmacrophage chemotaxis
B0048247biological_processlymphocyte chemotaxis
B0050729biological_processpositive regulation of inflammatory response
B0050795biological_processregulation of behavior
B0050850biological_processpositive regulation of calcium-mediated signaling
B0050918biological_processpositive chemotaxis
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051928biological_processpositive regulation of calcium ion transport
B0051930biological_processregulation of sensory perception of pain
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070723biological_processresponse to cholesterol
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0071621biological_processgranulocyte chemotaxis
B0090280biological_processpositive regulation of calcium ion import
B1903980biological_processpositive regulation of microglial cell activation
B1904141biological_processpositive regulation of microglial cell migration
B2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFsytsrq..IpqnfIaaYfetssq..Cskp.GVIFltkrsrqv.CA
ChainResidueDetails
ACYS10-ALA51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsSITE: Involved in GAG binding
ChainResidueDetails
AARG17
AARG45
AARG47
BARG17
BARG45
BARG47

227344

PDB entries from 2024-11-13

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