1B4W
BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS-IMPLICATIONS FOR ITS ASSOCIATION AND ANTICOAGULANT ACTIVITIES BY X-RAY CRYSTALLOGRAPHY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0050482 | biological_process | arachidonate secretion |
| C | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006644 | biological_process | phospholipid metabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0042130 | biological_process | negative regulation of T cell proliferation |
| C | 0050482 | biological_process | arachidonate secretion |
| D | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005543 | molecular_function | phospholipid binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006644 | biological_process | phospholipid metabolic process |
| D | 0016042 | biological_process | lipid catabolic process |
| D | 0042130 | biological_process | negative regulation of T cell proliferation |
| D | 0050482 | biological_process | arachidonate secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | ACTIVE SITE 1 |
| Chain | Residue |
| A | HIS48 |
| A | ASP99 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | ACTIVE SITE 2 |
| Chain | Residue |
| B | HIS48 |
| B | ASP99 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | ACTIVE SITE 3 |
| Chain | Residue |
| C | HIS48 |
| C | ASP99 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | ACTIVE SITE 4 |
| Chain | Residue |
| D | HIS48 |
| D | ASP99 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P06859","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9761847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JIA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS48 | |
| A | GLY30 | |
| A | ASP99 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| B | HIS48 | |
| B | GLY30 | |
| B | ASP99 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| C | HIS48 | |
| C | GLY30 | |
| C | ASP99 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| D | HIS48 | |
| D | GLY30 | |
| D | ASP99 |
