Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UFP A 280 |
| Chain | Residue |
| A | ARG28 |
| A | HIS222 |
| A | TYR224 |
| A | C2F281 |
| A | HOH291 |
| A | HOH313 |
| A | TYR108 |
| A | CYS161 |
| A | ARG181 |
| A | SER182 |
| A | ASN183 |
| A | ASP184 |
| A | GLY188 |
| A | ASN192 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE C2F A 281 |
| Chain | Residue |
| A | ALA64 |
| A | THR67 |
| A | ILE93 |
| A | TRP94 |
| A | TRP97 |
| A | ASP184 |
| A | GLY188 |
| A | ALA278 |
| A | UFP280 |
| A | HOH299 |
| A | HOH332 |
| A | HOH342 |
| A | HOH351 |
| A | HOH360 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrhItmlWNpdeldama.....LtPCVyetQWyV |
| Chain | Residue | Details |
| A | ARG141-VAL169 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
