1AY4
AROMATIC AMINO ACID AMINOTRANSFERASE WITHOUT SUBSTRATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| A | 0004838 | molecular_function | L-tyrosine-2-oxoglutarate transaminase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0033585 | biological_process | L-phenylalanine biosynthetic process from chorismate via phenylpyruvate |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
| B | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| B | 0004838 | molecular_function | L-tyrosine-2-oxoglutarate transaminase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0033585 | biological_process | L-phenylalanine biosynthetic process from chorismate via phenylpyruvate |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP A 413 |
| Chain | Residue |
| A | GLY108 |
| A | ARG266 |
| A | HOH522 |
| B | TYR70 |
| A | THR109 |
| A | TRP140 |
| A | ASN194 |
| A | ASP222 |
| A | TYR225 |
| A | SER255 |
| A | SER257 |
| A | LYS258 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP B 413 |
| Chain | Residue |
| A | TYR70 |
| B | GLY108 |
| B | THR109 |
| B | TRP140 |
| B | ASN194 |
| B | ASP222 |
| B | ALA224 |
| B | TYR225 |
| B | SER255 |
| B | SER257 |
| B | LYS258 |
| B | ARG266 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY38 | |
| B | ARG386 | |
| A | TYR70 | |
| A | TRP140 | |
| A | ASN194 | |
| A | ARG386 | |
| B | GLY38 | |
| B | TYR70 | |
| B | TRP140 | |
| B | ASN194 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS258 | |
| B | LYS258 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9665848 |
| Chain | Residue | Details |
| A | TRP140 | |
| A | ASP222 | |
| A | LYS258 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9665848 |
| Chain | Residue | Details |
| B | TRP140 | |
| B | ASP222 | |
| B | LYS258 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 411 |
| Chain | Residue | Details |
| A | TRP140 | steric role |
| A | ASP222 | electrostatic stabiliser |
| A | ALA224 | steric role |
| A | LYS258 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 411 |
| Chain | Residue | Details |
| B | TRP140 | steric role |
| B | ASP222 | electrostatic stabiliser |
| B | ALA224 | steric role |
| B | LYS258 | covalent catalysis, proton shuttle (general acid/base) |
