1AWR

CYPA COMPLEXED WITH HAGPIA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006457	biological_process	protein folding
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006915	biological_process	apoptotic process
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0019076	biological_process	viral release from host cell
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031982	cellular_component	vesicle
A	0032148	biological_process	activation of protein kinase B activity
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032991	cellular_component	protein-containing complex
A	0034389	biological_process	lipid droplet organization
A	0034599	biological_process	cellular response to oxidative stress
A	0034774	cellular_component	secretory granule lumen
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0042118	biological_process	endothelial cell activation
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045069	biological_process	regulation of viral genome replication
A	0045070	biological_process	positive regulation of viral genome replication
A	0046790	molecular_function	virion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060352	biological_process	cell adhesion molecule production
A	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1903901	biological_process	negative regulation of viral life cycle
A	1904399	molecular_function	heparan sulfate binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001233	biological_process	regulation of apoptotic signaling pathway
B	0000413	biological_process	protein peptidyl-prolyl isomerization
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0003723	molecular_function	RNA binding
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006457	biological_process	protein folding
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006915	biological_process	apoptotic process
B	0016018	molecular_function	cyclosporin A binding
B	0016020	cellular_component	membrane
B	0019076	biological_process	viral release from host cell
B	0030168	biological_process	platelet activation
B	0030182	biological_process	neuron differentiation
B	0030593	biological_process	neutrophil chemotaxis
B	0030595	biological_process	leukocyte chemotaxis
B	0031982	cellular_component	vesicle
B	0032148	biological_process	activation of protein kinase B activity
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0032991	cellular_component	protein-containing complex
B	0034389	biological_process	lipid droplet organization
B	0034599	biological_process	cellular response to oxidative stress
B	0034774	cellular_component	secretory granule lumen
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0042118	biological_process	endothelial cell activation
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045069	biological_process	regulation of viral genome replication
B	0045070	biological_process	positive regulation of viral genome replication
B	0046790	molecular_function	virion binding
B	0050714	biological_process	positive regulation of protein secretion
B	0051082	molecular_function	unfolded protein binding
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0060352	biological_process	cell adhesion molecule production
B	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B	1903901	biological_process	negative regulation of viral life cycle
B	1904399	molecular_function	heparan sulfate binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2001233	biological_process	regulation of apoptotic signaling pathway
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0003723	molecular_function	RNA binding
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006457	biological_process	protein folding
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006915	biological_process	apoptotic process
C	0016018	molecular_function	cyclosporin A binding
C	0016020	cellular_component	membrane
C	0019076	biological_process	viral release from host cell
C	0030168	biological_process	platelet activation
C	0030182	biological_process	neuron differentiation
C	0030593	biological_process	neutrophil chemotaxis
C	0030595	biological_process	leukocyte chemotaxis
C	0031982	cellular_component	vesicle
C	0032148	biological_process	activation of protein kinase B activity
C	0032873	biological_process	negative regulation of stress-activated MAPK cascade
C	0032991	cellular_component	protein-containing complex
C	0034389	biological_process	lipid droplet organization
C	0034599	biological_process	cellular response to oxidative stress
C	0034774	cellular_component	secretory granule lumen
C	0035307	biological_process	positive regulation of protein dephosphorylation
C	0042118	biological_process	endothelial cell activation
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045069	biological_process	regulation of viral genome replication
C	0045070	biological_process	positive regulation of viral genome replication
C	0046790	molecular_function	virion binding
C	0050714	biological_process	positive regulation of protein secretion
C	0051082	molecular_function	unfolded protein binding
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0060352	biological_process	cell adhesion molecule production
C	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
C	0070062	cellular_component	extracellular exosome
C	0070527	biological_process	platelet aggregation
C	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1903901	biological_process	negative regulation of viral life cycle
C	1904399	molecular_function	heparan sulfate binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2001233	biological_process	regulation of apoptotic signaling pathway
D	0000413	biological_process	protein peptidyl-prolyl isomerization
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0003723	molecular_function	RNA binding
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006457	biological_process	protein folding
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006915	biological_process	apoptotic process
D	0016018	molecular_function	cyclosporin A binding
D	0016020	cellular_component	membrane
D	0019076	biological_process	viral release from host cell
D	0030168	biological_process	platelet activation
D	0030182	biological_process	neuron differentiation
D	0030593	biological_process	neutrophil chemotaxis
D	0030595	biological_process	leukocyte chemotaxis
D	0031982	cellular_component	vesicle
D	0032148	biological_process	activation of protein kinase B activity
D	0032873	biological_process	negative regulation of stress-activated MAPK cascade
D	0032991	cellular_component	protein-containing complex
D	0034389	biological_process	lipid droplet organization
D	0034599	biological_process	cellular response to oxidative stress
D	0034774	cellular_component	secretory granule lumen
D	0035307	biological_process	positive regulation of protein dephosphorylation
D	0042118	biological_process	endothelial cell activation
D	0043410	biological_process	positive regulation of MAPK cascade
D	0045069	biological_process	regulation of viral genome replication
D	0045070	biological_process	positive regulation of viral genome replication
D	0046790	molecular_function	virion binding
D	0050714	biological_process	positive regulation of protein secretion
D	0051082	molecular_function	unfolded protein binding
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0060352	biological_process	cell adhesion molecule production
D	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
D	0070062	cellular_component	extracellular exosome
D	0070527	biological_process	platelet aggregation
D	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D	1903901	biological_process	negative regulation of viral life cycle
D	1904399	molecular_function	heparan sulfate binding
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2001233	biological_process	regulation of apoptotic signaling pathway
E	0000413	biological_process	protein peptidyl-prolyl isomerization
E	0001933	biological_process	negative regulation of protein phosphorylation
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0003723	molecular_function	RNA binding
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005178	molecular_function	integrin binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006457	biological_process	protein folding
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006915	biological_process	apoptotic process
E	0016018	molecular_function	cyclosporin A binding
E	0016020	cellular_component	membrane
E	0019076	biological_process	viral release from host cell
E	0030168	biological_process	platelet activation
E	0030182	biological_process	neuron differentiation
E	0030593	biological_process	neutrophil chemotaxis
E	0030595	biological_process	leukocyte chemotaxis
E	0031982	cellular_component	vesicle
E	0032148	biological_process	activation of protein kinase B activity
E	0032873	biological_process	negative regulation of stress-activated MAPK cascade
E	0032991	cellular_component	protein-containing complex
E	0034389	biological_process	lipid droplet organization
E	0034599	biological_process	cellular response to oxidative stress
E	0034774	cellular_component	secretory granule lumen
E	0035307	biological_process	positive regulation of protein dephosphorylation
E	0042118	biological_process	endothelial cell activation
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045069	biological_process	regulation of viral genome replication
E	0045070	biological_process	positive regulation of viral genome replication
E	0046790	molecular_function	virion binding
E	0050714	biological_process	positive regulation of protein secretion
E	0051082	molecular_function	unfolded protein binding
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0060352	biological_process	cell adhesion molecule production
E	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
E	0070062	cellular_component	extracellular exosome
E	0070527	biological_process	platelet aggregation
E	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1903901	biological_process	negative regulation of viral life cycle
E	1904399	molecular_function	heparan sulfate binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2001233	biological_process	regulation of apoptotic signaling pathway
F	0000413	biological_process	protein peptidyl-prolyl isomerization
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0003723	molecular_function	RNA binding
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005178	molecular_function	integrin binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005925	cellular_component	focal adhesion
F	0006457	biological_process	protein folding
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006915	biological_process	apoptotic process
F	0016018	molecular_function	cyclosporin A binding
F	0016020	cellular_component	membrane
F	0019076	biological_process	viral release from host cell
F	0030168	biological_process	platelet activation
F	0030182	biological_process	neuron differentiation
F	0030593	biological_process	neutrophil chemotaxis
F	0030595	biological_process	leukocyte chemotaxis
F	0031982	cellular_component	vesicle
F	0032148	biological_process	activation of protein kinase B activity
F	0032873	biological_process	negative regulation of stress-activated MAPK cascade
F	0032991	cellular_component	protein-containing complex
F	0034389	biological_process	lipid droplet organization
F	0034599	biological_process	cellular response to oxidative stress
F	0034774	cellular_component	secretory granule lumen
F	0035307	biological_process	positive regulation of protein dephosphorylation
F	0042118	biological_process	endothelial cell activation
F	0043410	biological_process	positive regulation of MAPK cascade
F	0045069	biological_process	regulation of viral genome replication
F	0045070	biological_process	positive regulation of viral genome replication
F	0046790	molecular_function	virion binding
F	0050714	biological_process	positive regulation of protein secretion
F	0051082	molecular_function	unfolded protein binding
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0060352	biological_process	cell adhesion molecule production
F	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
F	0070062	cellular_component	extracellular exosome
F	0070527	biological_process	platelet aggregation
F	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F	1903901	biological_process	negative regulation of viral life cycle
F	1904399	molecular_function	heparan sulfate binding
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2001233	biological_process	regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG

Chain	Residue	Details
A	TYR1048-GLY1065

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	VAL1002
B	VAL1002
C	VAL1002
D	VAL1002
E	VAL1002
F	VAL1002

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000269|PubMed:25489052, ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ASN1003
B	ASN1003
C	ASN1003
D	ASN1003
E	ASN1003
F	ASN1003

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	VAL1029
E	PHE1083
F	VAL1029
F	PHE1083
A	PHE1083
B	VAL1029
B	PHE1083
C	VAL1029
C	PHE1083
D	VAL1029
D	PHE1083
E	VAL1029

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	GLY1045
D	GLY1045
D	SER1077
D	VAL1132
E	GLY1045
E	SER1077
E	VAL1132
F	GLY1045
F	SER1077
F	VAL1132
A	SER1077
A	VAL1132
B	GLY1045
B	SER1077
B	VAL1132
C	GLY1045
C	SER1077
C	VAL1132

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ILE1078
B	ILE1078
C	ILE1078
D	ILE1078
E	ILE1078
F	ILE1078

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	GLY1094
B	GLY1094
C	GLY1094
D	GLY1094
E	GLY1094
F	GLY1094

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20364129, ECO:0000269|PubMed:25678563, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	HIS1126
B	HIS1126
C	HIS1126
D	HIS1126
E	HIS1126
F	HIS1126

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17742

Chain	Residue	Details
A	GLU1134
B	GLU1134
C	GLU1134
D	GLU1134
E	GLU1134
F	GLU1134

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLY1109
B	GLY1109
C	GLY1109
D	GLY1109
E	GLY1109
F	GLY1109

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	VAL1029
B	VAL1029
C	VAL1029
D	VAL1029
E	VAL1029
F	VAL1029

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	PHE1083
F	PHE1083
A	PHE1083
B	PHE1083
C	PHE1083
D	PHE1083

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
A	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
A	MET1061	polar/non-polar interaction, steric role
A	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ILE1114	polar/non-polar interaction, steric role
A	ASP1123	polar/non-polar interaction, steric role
A	VAL1127	polar/non-polar interaction, steric role

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
B	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
B	MET1061	polar/non-polar interaction, steric role
B	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	ILE1114	polar/non-polar interaction, steric role
B	ASP1123	polar/non-polar interaction, steric role
B	VAL1127	polar/non-polar interaction, steric role

---

site_id	MCSA3
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
C	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
C	MET1061	polar/non-polar interaction, steric role
C	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
C	ILE1114	polar/non-polar interaction, steric role
C	ASP1123	polar/non-polar interaction, steric role
C	VAL1127	polar/non-polar interaction, steric role

---

site_id	MCSA4
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
D	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
D	MET1061	polar/non-polar interaction, steric role
D	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
D	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
D	ILE1114	polar/non-polar interaction, steric role
D	ASP1123	polar/non-polar interaction, steric role
D	VAL1127	polar/non-polar interaction, steric role

---

site_id	MCSA5
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
E	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
E	MET1061	polar/non-polar interaction, steric role
E	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
E	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
E	ILE1114	polar/non-polar interaction, steric role
E	ASP1123	polar/non-polar interaction, steric role
E	VAL1127	polar/non-polar interaction, steric role

---

site_id	MCSA6
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
F	ILE1056	electrostatic stabiliser, hydrogen bond donor, steric role
F	MET1061	polar/non-polar interaction, steric role
F	GLY1064	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
F	ALA1103	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
F	ILE1114	polar/non-polar interaction, steric role
F	ASP1123	polar/non-polar interaction, steric role
F	VAL1127	polar/non-polar interaction, steric role

---