Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1AW8

PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004068molecular_functionaspartate 1-decarboxylase activity
A0006523biological_processalanine biosynthetic process
B0004068molecular_functionaspartate 1-decarboxylase activity
B0006523biological_processalanine biosynthetic process
D0004068molecular_functionaspartate 1-decarboxylase activity
D0006523biological_processalanine biosynthetic process
E0004068molecular_functionaspartate 1-decarboxylase activity
E0006523biological_processalanine biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SER B 25
ChainResidue
BSER70
BVAL71
BASN72
ATYR22
AGLU23
AGLY24
BPYR25
BCYS26
BTHR57
BTYR58

site_idNUL
Number of Residues2
DetailsPVL RESIDUES
ChainResidue
BPYR25
EPYR25

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:9546220
ChainResidueDetails
BPYR25
EPYR25

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
BTYR58
ETYR58

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BTHR57
BGLY73
ETHR57
EGLY73

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Pyruvic acid (Ser) => ECO:0000269|PubMed:9546220
ChainResidueDetails
BPYR25
EPYR25

Catalytic Information from CSA
site_idCSA1
Number of Residues2
Detailsa catalytic site defined by CSA, PubMed 12240302, 15184017
ChainResidueDetails
ALYS9
BTYR58

site_idCSA2
Number of Residues1
Detailsa catalytic site defined by CSA, PubMed 12240302, 15184017
ChainResidueDetails
ETYR58

site_idMCSA1
Number of Residues2
DetailsM-CSA 409
ChainResidueDetails
BPYR25covalently attached, electrofuge, electrophile
BTYR58activator, increase nucleophilicity, proton acceptor, proton donor

site_idMCSA2
Number of Residues2
DetailsM-CSA 409
ChainResidueDetails
EPYR25covalently attached, electrofuge, electrophile
ETYR58activator, increase nucleophilicity, proton acceptor, proton donor

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon