Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1AW1

TRIOSEPHOSPHATE ISOMERASE OF VIBRIO MARINUS COMPLEXED WITH 2-PHOSPHOGLYCOLATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016853	molecular_function	isomerase activity
G	0019563	biological_process	glycerol catabolic process
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016853	molecular_function	isomerase activity
H	0019563	biological_process	glycerol catabolic process
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
J	0004807	molecular_function	triose-phosphate isomerase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006094	biological_process	gluconeogenesis
J	0006096	biological_process	glycolytic process
J	0016853	molecular_function	isomerase activity
J	0019563	biological_process	glycerol catabolic process
J	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
K	0004807	molecular_function	triose-phosphate isomerase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006094	biological_process	gluconeogenesis
K	0006096	biological_process	glycolytic process
K	0016853	molecular_function	isomerase activity
K	0019563	biological_process	glycerol catabolic process
K	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGA A 290

Chain	Residue
A	LYS11
A	GLY235
A	GLY236
A	HOH309
A	HOH313
A	HOH314
A	HIS97
A	GLU169
A	ALA173
A	ILE174
A	GLY175
A	GLY213
A	SER214
A	LEU233

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PGA B 290

Chain	Residue
B	LYS11
B	HIS97
B	GLU169
B	ALA173
B	ILE174
B	GLY175
B	GLY213
B	SER214
B	LEU233
B	GLY235
B	GLY236
B	HOH303

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGA D 290

Chain	Residue
D	LYS11
D	HIS97
D	GLU169
D	ALA173
D	ILE174
D	GLY175
D	GLY213
D	SER214
D	LEU233
D	GLY235
D	GLY236
D	HOH308
D	HOH312
D	HOH313

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PGA E 290

Chain	Residue
E	LYS11
E	HIS97
E	GLU169
E	ALA173
E	ILE174
E	GLY175
E	GLY213
E	SER214
E	LEU233
E	GLY235
E	GLY236
E	HOH303

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGA G 290

Chain	Residue
G	LYS11
G	HIS97
G	GLU169
G	ALA173
G	ILE174
G	GLY175
G	GLY213
G	SER214
G	LEU233
G	GLY235
G	GLY236
G	HOH309
G	HOH313
G	HOH314

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PGA H 290

Chain	Residue
H	LYS11
H	HIS97
H	GLU169
H	ALA173
H	ILE174
H	GLY175
H	GLY213
H	SER214
H	LEU233
H	GLY235
H	GLY236
H	HOH303

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGA J 290

Chain	Residue
J	LYS11
J	HIS97
J	GLU169
J	ALA173
J	ILE174
J	GLY175
J	GLY213
J	SER214
J	LEU233
J	GLY235
J	GLY236
J	HOH310
J	HOH314
J	HOH315

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PGA K 290

Chain	Residue
K	SER214
K	LEU233
K	GLY235
K	GLY236
K	HOH303
K	LYS11
K	HIS97
K	GLU169
K	ALA173
K	ILE174
K	GLY175
K	GLY213

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPIWAIGTG

Chain	Residue	Details
A	ALA167-GLY177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9442062","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9442062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
A	HIS97
A	GLY175
A	GLU169
A	LYS11
A	ASN9

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
B	HIS97
B	GLY175
B	GLU169
B	LYS11
B	ASN9

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
D	HIS97
D	GLY175
D	GLU169
D	LYS11
D	ASN9

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
E	HIS97
E	GLY175
E	GLU169
E	LYS11
E	ASN9

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
G	HIS97
G	GLY175
G	GLU169
G	LYS11
G	ASN9

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
H	HIS97
H	GLY175
H	GLU169
H	LYS11
H	ASN9

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
J	HIS97
J	GLY175
J	GLU169
J	LYS11
J	ASN9

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
K	HIS97
K	GLY175
K	GLU169
K	LYS11
K	ASN9

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)