1AVP

STRUCTURE OF HUMAN ADENOVIRUS 2 PROTEINASE WITH ITS 11 AMINO ACID COFACTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0042025	cellular_component	host cell nucleus
A	0044423	cellular_component	virion component

Functional Information from PDB Data

site_id	ACT
Number of Residues	3
Details

Chain	Residue
A	HIS54
A	CYS122
A	GLU71

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_04059, ECO:0000269|PubMed:8617222

Chain	Residue	Details
A	HIS54
A	GLU71
A	CYS122

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000255|HAMAP-Rule:MF_04059

Chain	Residue	Details
A	GLY51

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 679

Chain	Residue	Details
A	HIS54	proton acceptor, proton donor
A	GLU71	electrostatic stabiliser
A	GLN115	electrostatic stabiliser
A	CYS122	nucleofuge, nucleophile, proton acceptor, proton donor

---