1AVH
CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0004859 | molecular_function | phospholipase inhibitor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007596 | biological_process | blood coagulation |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0010033 | biological_process | response to organic substance |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0050819 | biological_process | negative regulation of coagulation |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072563 | cellular_component | endothelial microparticle |
| B | 0001786 | molecular_function | phosphatidylserine binding |
| B | 0004859 | molecular_function | phospholipase inhibitor activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0007165 | biological_process | signal transduction |
| B | 0007596 | biological_process | blood coagulation |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0010033 | biological_process | response to organic substance |
| B | 0012506 | cellular_component | vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0050819 | biological_process | negative regulation of coagulation |
| B | 0062023 | cellular_component | collagen-containing extracellular matrix |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072563 | cellular_component | endothelial microparticle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 321 |
| Chain | Residue |
| A | LEU100 |
| A | GLY102 |
| A | GLY104 |
| B | LEU31 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 321 |
| Chain | Residue |
| B | MET28 |
| B | GLY30 |
| B | GLY32 |
| B | THR33 |
| B | GLU72 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 322 |
| Chain | Residue |
| B | MET259 |
| B | GLY261 |
| B | GLY263 |
| B | ASP303 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 541 |
| Chain | Residue |
| A | LYS79 |
| A | HOH676 |
| B | ALA262 |
| B | GLY263 |
| B | THR264 |
| B | HOH787 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 543 |
| Chain | Residue |
| A | GLY75 |
| A | LYS76 |
| A | HOH656 |
| A | HOH819 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 542 |
| Chain | Residue |
| A | THR105 |
| B | ARG25 |
| B | GLY30 |
| B | ARG63 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 545 |
| Chain | Residue |
| B | GLU22 |
| B | ARG201 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL |
| Chain | Residue | Details |
| A | GLY32-LEU84 | |
| A | GLY104-LEU156 | |
| A | GLY188-VAL240 | |
| A | GLY263-LEU315 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | GLN3 | |
| B | GLN3 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48036 |
| Chain | Residue | Details |
| A | ILE38 | |
| B | ILE38 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | SER71 | |
| A | PHE77 | |
| A | LEU80 | |
| A | HIS98 | |
| B | SER71 | |
| B | PHE77 | |
| B | LEU80 | |
| B | HIS98 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:16916647 |
| Chain | Residue | Details |
| A | GLY102 | |
| B | GLY102 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48036 |
| Chain | Residue | Details |
| A | ASN291 | |
| B | ASN291 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | GLY30 | |
| B | GLY30 |
