Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1AR1

Structure at 2.7 Angstrom Resolution of the Paracoccus Denitrificans two-subunit Cytochrome C Oxidase Complexed with an Antibody Fv Fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
C	0002250	biological_process	adaptive immune response
C	0003823	molecular_function	antigen binding
C	0016064	biological_process	immunoglobulin mediated immune response
C	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 270

Chain	Residue
B	CYS216
B	GLU218
B	CYS220
B	HIS224
B	CU271

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 271

Chain	Residue
B	HIS181
B	CYS216
B	CYS220
B	MET227
B	CU270

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU A 559

Chain	Residue
A	HIS276
A	HIS325
A	HIS326

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 560

Chain	Residue
A	HIS403
A	ASP404
A	HOH574
B	SER217
B	GLU218

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 561

Chain	Residue
A	GLU56
A	HIS59
A	GLY61
A	GLN63
A	ASP477

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEA A 562

Chain	Residue
A	THR50
A	ARG54
A	TRP87
A	ILE91
A	HIS94
A	MET98
A	MET99
A	VAL103
A	GLY163
A	TRP164
A	TYR406
A	HIS413
A	MET416
A	SER417
A	PHE460
A	ARG473
A	ARG474
A	TYR475
A	SER496
A	PHE503
A	HOH575

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEA A 563

Chain	Residue
A	TRP164
A	TRP272
A	VAL279
A	TYR280
A	HIS325
A	HIS326
A	THR344
A	ILE347
A	ALA348
A	THR351
A	GLY352
A	GLY387
A	GLY390
A	LEU393
A	SER394
A	ASP399
A	HIS403
A	VAL408
A	HIS411
A	PHE412
A	VAL415
A	MET416
A	ARG473
A	HOH571
A	HOH572

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LDA B 272

Chain	Residue
A	PHE465
A	ARG468
A	LDA569
B	ASN19

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LDA B 273

Chain	Residue
B	MET18

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LDA A 564

Chain	Residue
A	PHE369

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LDA A 565

Chain	Residue
A	TRP363
B	ASN74
B	TRP81

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LDA A 566

Chain	Residue
A	LEU511
A	ILE33
A	SER436

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LDA A 568

Chain	Residue
A	TRP443
A	GLY505
A	ILE506

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LDA B 274

Chain	Residue
B	VAL90
B	ALA94
B	PRO98

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LDA A 569

Chain	Residue
A	PHE461
B	LDA272

site_id	CA
Number of Residues	4
Details	NON REDOX ACTIVE CA BINDING SITE.

Chain	Residue
A	GLU56
A	HIS59
A	GLY61
A	GLN63

site_id	CUA
Number of Residues	6
Details	CU A BINDING SITE.

Chain	Residue
B	HIS181
B	CYS216
B	GLU218
B	CYS220
B	HIS224
B	MET227

site_id	CUB
Number of Residues	3
Details	CU B BINDING SITE.

Chain	Residue
A	HIS276
A	HIS325
A	HIS326

site_id	HM3
Number of Residues	1
Details	AXIAL HEME A3 LIGAND.

Chain	Residue
A	HIS411

site_id	HMA
Number of Residues	2
Details	AXIAL HEME A LIGANDS.

Chain	Residue
A	HIS94
A	HIS413

site_id	MM
Number of Residues	3
Details	NON REDOX ACTIVE MN/MG BINDING SITE.

Chain	Residue
A	HIS403
A	ASP404
B	GLU218

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiiilpgfgiishvistfakkpifgylpmvlamaaigilgfvvwa..HH

Chain	Residue	Details
A	TRP272-HIS326

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHawtipafavkqdavpgriaqlwfsvdqegvyfgq......CselCginHayM

Chain	Residue	Details
B	VAL179-MET227

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	170
Details	TOPO_DOM: Periplasmic

Chain	Residue	Details
B	GLN1-PRO26
B	MET106-ALA251
A	MET207-VAL217
A	LYS300-PHE303
A	GLY365-PHE369
A	ARG438-TYR440
A	LYS515-HIS558

site_id	SWS_FT_FI2
Number of Residues	62
Details	TRANSMEM: Helical

Chain	Residue	Details
B	LEU27-ARG59
B	THR75-GLU105

site_id	SWS_FT_FI3
Number of Residues	14
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
B	PHE60-ASN74
A	PRO152-GLY176
A	GLY252-GLY262
A	MET332
A	ALA396-ASP404
A	GLY470-TYR478

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
B	HIS181
B	CYS216
B	GLU218
B	CYS220
B	HIS224
B	MET227

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:2820725

Chain	Residue	Details
B	GLN1

site_id	SWS_FT_FI6
Number of Residues	29
Details	TRANSMEM: Helical; Name=IV

Chain	Residue	Details
A	TYR177-ASN206

site_id	SWS_FT_FI7
Number of Residues	33
Details	TRANSMEM: Helical; Name=V

Chain	Residue	Details
A	PRO218-PHE251

site_id	SWS_FT_FI8
Number of Residues	36
Details	TRANSMEM: Helical; Name=VI

Chain	Residue	Details
A	ASP263-LYS299

site_id	SWS_FT_FI9
Number of Residues	27
Details	TRANSMEM: Helical; Name=VII

Chain	Residue	Details
A	GLY304-GLY331

site_id	SWS_FT_FI10
Number of Residues	31
Details	TRANSMEM: Helical; Name=VIII

Chain	Residue	Details
A	SER333-GLY364

site_id	SWS_FT_FI11
Number of Residues	25
Details	TRANSMEM: Helical; Name=IX

Chain	Residue	Details
A	LYS370-GLN395

site_id	SWS_FT_FI12
Number of Residues	32
Details	TRANSMEM: Helical; Name=X

Chain	Residue	Details
A	THR405-GLY437

site_id	SWS_FT_FI13
Number of Residues	28
Details	TRANSMEM: Helical; Name=XI

Chain	Residue	Details
A	PRO441-GLN469

site_id	SWS_FT_FI14
Number of Residues	35
Details	TRANSMEM: Helical; Name=XII

Chain	Residue	Details
A	PRO479-GLY514

site_id	SWS_FT_FI15
Number of Residues	3
Details	BINDING: axial binding residue

Chain	Residue	Details
A	HIS94
A	HIS411
A	HIS413

site_id	SWS_FT_FI16
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	HIS276
A	TYR280
A	HIS325
A	HIS326

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr)

Chain	Residue	Details
A	HIS276
A	TYR280

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 9788998

Chain	Residue	Details
A	GLU278
A	LYS354

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)